General Information of HIF (ID: HIFM0272)
HIF Name	Immunoglobulin A
HIF Synonym(s)	IgA
HIF Classification	Immunoglobulin (Ig)
Description	Immunoglobulin A(IgA) is the main antibody isotype secreted into the intestinal lumen. IgA plays a critical role in the defence against pathogens and in the maintenance of intestinal homeostasis.It has two subtypes termed IgA1 and IgA2 in human.				[1]

Microbe Species (MIC) Regulated by This HIF
Acidaminococcus fermentans (firmicutes)			MIC00008
Description	Acidaminococcus spp. were selectively IgA+(High IgA binding) coated in patients with inflammatory bowel disease(Crohn disease and ulcerative colitis).				[2]
Adlercreutzia equolifaciens (actinobacteria)			MIC00042
Description	Adlercreutzia was significantly enriched in the IgA(Low or no IgA binding) consortia.				[2]
Aggregatibacter actinomycetemcomitans (gamma-proteobacteria)			MIC00051
Description	The activity of proteolytic enzymes from Actinobacillus actinomycetemcomitans could effect enzymolysis of human immunoglobulin A(lgA).				[3]
Allobaculum (firmicutes)			MIC01850
Description	Allobaculum spp. were selectively IgA+ (High IgA binding) coated in patients with inflammatory bowel disease (Crohn disease and ulcerative colitis).				[2]
Amedibacillus dolichus (firmicutes)			MIC01807
Description	Eubacterium dolichum was selectively IgA+ (High IgA binding) coated in patients with inflammatory bowel disease (Crohn disease and ulcerative colitis).				[2]
Anaerostipes hadrus (firmicutes)			MIC01441
Description	Anaerostipes was significantly enriched in the IgA (Low or no IgA binding) consortia.				[2]
Bacillus firmus (firmicutes)			MIC00127
Description	Bacillus firmus can stimulate the formation of immunoglobulin A(IgA).				[4]
Bacillus lentus (firmicutes)			MIC00131
Description	Bacillus lentus can stimulate the formation of immunoglobulin A(IgA).				[4]
Bacteroides caccae (CFB bacteria)			MIC00148
Description	The abundance of Bacteroides caccae is associated with the IgA.				[5]
Bacteroides fragilis (CFB bacteria)			MIC00158
Description	IgA has regulatory affinity which could bind to Bacteroides fragilis.				[6]
Bacteroides sp. (CFB bacteria)			MIC00176
Description	Bacteroides was significantly enriched in the IgA(Low or no IgA binding) consortia.				[2]
Bacteroides thetaiotaomicron (CFB bacteria)			MIC00179
Description	IgA could interact with Bacteroides thetaiotaomicron.				[7]
Bacteroides uniformis (CFB bacteria)			MIC00184
Description	Bacteroides uniformis is negatively associated with IgA.				[6]
Bacteroides vulgatus (CFB bacteria)			MIC00186
Description	Bacteroides vulgatus was selectively IgA+(High IgA binding) coated in patients with inflammatory bowel disease(Crohn disease and ulcerative colitis).				[2]
Bifidobacterium sp. (actinobacteria)			MIC00224
Description	Levels of IgA correlated with relative abundances of operational taxonomic units (OTUs) belonging to the Bifidobacteria.				[8]
Bilophila wadsworthia (delta-proteobacteria)			MIC00235
Description	Bilophila was significantly enriched in the IgA(Low or no IgA binding) consortia.				[2]
Blautia producta (firmicutes)			MIC00981
Description	Blautia was selectively IgA+(High IgA binding) coated in patients with inflammatory bowel disease(Crohn disease and ulcerative colitis).				[2]
Candida albicans (budding yeasts)			MIC00317
Description	IgA is raised and protected from the intravaginal challenge with Candida albicans.				[9]
Candidatus Arthromitus (firmicutes)			MIC00319
Description	Candidatus arthromitus was selectively IgA+(High IgA binding) coated in patients with inflammatory bowel disease(Crohn disease and ulcerative colitis).				[2]
Candidatus Arthromitus sp. SFB-mouse (firmicutes)			MIC01824
Description	Affinity-maturated IgA appear necessary for SFB(Segmented Filamentous Bacteria) pathobiont control.				[7]
Citrobacter koseri (enterobacteria)			MIC00365
Description	IgM responses to OSEs and NO-cysteinyl were significantly associated with IgA/IgM responses to Gram-negative bacteria, especially Morganella morganii, Klebsiella pneumoniae and Citrobacter koseri.				[10]
Clostridia (firmicutes)			MIC01851
Description	IgAs could coat some Clostridial species.				[11]
Clostridioides difficile (firmicutes)			MIC00396
Description	Clostridium difficile is a Gram-positive, anaerobic, spore-forming, toxin-producing bacterium.The role of Clostridium difficile as a pathogen and as a causative agent for antibiotic-associated diarrhea and pseudomembranous colitis was first defined in 1978.				[12]
Clostridium innocuum (firmicutes)			MIC00400
Description	Clostridium innocuum could increase the level of IgA.				[13]
Clostridium sp. (firmicutes)			MIC00418
Description	Clostridium was significantly enriched in the IgA(Low or no IgA binding) consortia.				[2]
Coprococcus comes (firmicutes)			MIC00442
Description	Coprococcus comes, Dorea sp., and Clostridium sp. thrive in the presence of IgA.				[7]
Coprococcus sp. (firmicutes)			MIC00444
Description	Coprococcus was significantly enriched in the IgA(Low or no IgA binding) consortia.				[2]
Dehalobacterium (firmicutes)			MIC01825
Description	Dehalobacterium is significantly enriched in the IgA (Low or no IgA binding) consortia.				[2]
Dorea sp. (firmicutes)			MIC00513
Description	Dorea was significantly enriched in the IgA(Low or no IgA binding) consortia.				[2]
Eggerthella lenta (actinobacteria)			MIC00520
Description	Eggerthella lenta is negatively associated with IgA.				[6]
Entamoeba histolytica (eukaryotes)			MIC00528
Description	Entamoeba histolytica trophozoites could degrade the level of human IgA and result in the low IgA concentration.				[14]
Enterobacter sp. (enterobacteria)			MIC00535
Description	Enterobacteriaceae abundance is observed in patients with IBD and in preclinical models.Whether this bloom of microorganisms is related to microbemediated faecal IgA levels is unknown.				[15]
Enterococcus durans (firmicutes)			MIC00547
Description	Enterococcus durans EP1 Administration Increases sIgA in Feces.				[16]
Erysipelatoclostridium ramosum (firmicutes)			MIC00414
Description	Clostridium ramosum is negatively associated with IgA.				[6]
Erysipelothrix rhusiopathiae (firmicutes)			MIC00559
Description	Increases were seen in the concentrations of BALF IgA (but not IgG) and serum IgM against Mycoplasma hyopneumoniae and Erysipelothrix rhusiopathiae antigens, respectively.				[17]
Escherichia coli (enterobacteria)			MIC00516
Description	The monoclonal IgA antibodies W27 with potent relative binding ability against Escherichia coli (an optical density of about 4 at an antibody concentration of 50 ug/ml) could inhibit the enzymatic activity of the serine hydroxymethyltransferase, which resulted in growth suppression of Escherichia coli. When the concentrations of IgA W27 were 23 ug/ml, 70 ug/ml and 210 ug/ml, the cell growth of Escherichia coli was inhibited significantly in a dose-dependent manner (~108 cells, ~106 cells, ~103 cells, respectively) (p-value<0.05).				[1]
Fibrobacter intestinalis (bacteria)			MIC00593
Description	The SIgA-tagged microbiota from rumen and oral secretionhad similar abundance of Fibrobacter, and are clustered tightly.				[18]
Finegoldia magna (firmicutes)			MIC00596
Description	IgA has regulatory affinity which could bind to Peptococcus magnus strain.				[19]
Fusobacterium varium (fusobacteria)			MIC00621
Description	The abundance of Fusobacterium varium is associated with IgA immune response.				[20]
Haemophilus parainfluenzae (gamma-proteobacteria)			MIC00653
Description	Haemophilus parainfluenzae was selectively IgA+(High IgA binding) coated in patients with inflammatory bowel disease (Crohn disease and ulcerative colitis).				[2]
Helicobacter pylori (epsilon-proteobacteria)			MIC00669
Description	long time infection of Helicobacter pylori infection promoted the production of IgA.				[21]
Klebsiella pneumoniae (enterobacteria)			MIC01405
Description	IgM responses to OSEs and NO-cysteinyl were significantly associated with IgA/IgM responses to Gram-negative bacteria, especially Morganella morganii, Klebsiella pneumoniae and Citrobacter koseri.				[10]
Lachnospiraceae (firmicutes)			MIC00695
Description	Lachnospiraceae was significantly enriched in the IgA(Low or no IgA binding) consortia.				[2]
Lactobacillus casei (firmicutes)			MIC00707
Description	Lactobacillus casei is negatively associated with IgA.				[6]
Lactobacillus kefiranofaciens (firmicutes)			MIC00723
Description	The abundance of Lactobacillus kefiranofaciens is associated with IgA.				[22]
Lactobacillus sakei (firmicutes)			MIC00734
Description	MVs released from Lactobacillus sakei NBRC15893 could enhance IgA production.				[23]
Lactobacillus sp. (firmicutes)			MIC00701
Description	Lactobacillus was selectively IgA+ (High IgA binding) coated in patients with inflammatory bowel disease (Crohn disease and ulcerative colitis).				[2]
Leuconostoc mesenteroides (firmicutes)			MIC00766
Description	Leuconostoc mesenteroides is negatively associated with IgA.				[6]
Morganella morganii (enterobacteria)			MIC00839
Description	IgM responses to OSEs and NO-cysteinyl were significantly associated with IgA/IgM responses to Gram-negative bacteria, especially Morganella morganii, Klebsiella pneumoniae and Citrobacter koseri.				[10]
Mycobacterium avium (actinobacteria)			MIC00846
Description	GPL from Mycobacterium avium can induce the secretion of IL-6 primarily by monocytes in human peripheral blood monocytes, and the upregulation of IgA at mucosal sites in humans is induced by IL-6.				[24]
Mycobacterium kansasii (actinobacteria)			MIC01785
Description	The infection of Mycobacterium kansasii could transiently increase IgA.				[25]
Mycoplasma hyopneumoniae (mycoplasmas)			MIC00872
Description	Toll-like receptor 2 (TLR2) and TLR4 mediate the IgA immune response induced by Mycoplasma hyopneumoniae.				[26]
Mycoplasma pulmonis (mycoplasmas)			MIC00876
Description	Mycoplasma pulmonis could response to IgA.				[27]
Mycoplasmatales (mycoplasmas)			MIC00878
Description	Many mycoplasmas is related to certain unique features of the mycoplasma and its interaction with IgA.				[28]
Neisseria sp. (beta-proteobacteria)			MIC00900
Description	The abundance of Neisseriaceae is non-differing between SIgA-saliva and whole rumen.				[18]
Oscillospira sp. A (firmicutes)			MIC00933
Description	Oscillospira was significantly enriched in the IgA (Low or no IgA binding) consortia.				[2]
Pediococcus sp. (firmicutes)			MIC01872
Description	Unclassified pediococcus was selectively IgA+ (High IgA binding) coated in patients with inflammatory bowel disease (Crohn disease and ulcerative colitis).				[2]
Porphyromonas gingivalis (CFB bacteria)			MIC01000
Description	The activity of proteolytic enzymes from Porphyromonas gingivalis could effect enzymolysis of human immunoglobulin A(lgA).				[3]
Porphyromonas sp. (CFB bacteria)			MIC01003
Description	The relative abundances of Porphyromonadaceae increase is associated with an increase in serum IgA concentrations.				[29]
Prevotella copri (CFB bacteria)			MIC01010
Description	IgA could response to Prevotella copri.				[30]
Prevotella nanceiensis (CFB bacteria)			MIC01018
Description	Prevotella nanceiensis is positively associated with IgA.				[31]
Prevotellaceae (CFB bacteria)			MIC01028
Description	Prevotellaceae family is associated with antibiotic biosynthesis and transport of secondary metabolites.				[32]
Proteobacteria (proteobacteria)			MIC01037
Description	Serum IgAs has regulatory affinity which could bind prominently to Proteobacterial taxa.				[11]
Pseudomonas oleovorans (gamma-proteobacteria)			MIC01060
Description	The abundance of Pseudomonas oleovorans is associated with IgA immune responses.				[33]
Rikenella microfusus (CFB bacteria)			MIC01112
Description	Rikenellaceae gen.was significantly enriched in the IgA (Low or no IgA binding) consortia.				[2]
Roseburia sp. (firmicutes)			MIC01115
Description	Roseburia was selectively IgA+ (High IgA binding) coated in patients with inflammatory bowel disease (Crohn disease and ulcerative colitis).				[2]
Ruminococcus sp. (firmicutes)			MIC01140
Description	Ruminococcus was significantly enriched in the IgA (Low or no IgA binding) consortia.				[2]
Salmonella enterica subsp. enterica (enterobacteria)			MIC01154
Description	SIgA has immunity activity to Salmonella enterica serovar Typhimurium.				[34]
Serratia fonticola (enterobacteria)			MIC01169
Description	Serratia was coated by IgA.				[35]
Shigella dysenteriae (enterobacteria)			MIC01181
Description	IgA immune responses was associated with Shigella dysenteriae.				[36]
Shigella flexneri (enterobacteria)			MIC01182
Description	Secretory IgA showed could Shigella flexneri-induced intestine epithelial cell damage in an in vitro cell model.				[37]
Staphylococcus aureus (firmicutes)			MIC01208
Description	IgA immune responses is associated with Staphylococcus aureus.				[38]
Staphylococcus haemolyticus (firmicutes)			MIC01215
Description	Staphylococcus haemolyticus could be recognized by IgA.				[35]
Streptococcus constellatus (firmicutes)			MIC01245
Description	IgA immune responses is associated with Streptococcus constellatus SC10.				[39]
Streptococcus pneumoniae (firmicutes)			MIC01263
Description	IgA immune responses was associated with Streptococcus pneumoniae.				[40]
Sutterella parvirubra (beta-proteobacteria)			MIC01291
Description	Sutterella was significantly enriched in the IgA (Low or no IgA binding) consortia.				[2]
Veillonella dispar (firmicutes)			MIC01364
Description	Veillonella dispar was selectively IgA+ (High IgA binding) coated in patients with inflammatory bowel disease (Crohn disease and ulcerative colitis).				[2]
Veillonella parvula (firmicutes)			MIC01365
Description	Veillonella spp.was selectively IgA+ (High IgA binding) coated in patients with inflammatory bowel disease (Crohn disease and ulcerative colitis).				[2]
Verrucomicrobia (verrucomicrobia)			MIC01368
Description	Verrucomicrobia is highly enriched in the IgA+ fraction.				[11]
Vibrio cholerae (gamma-proteobacteria)			MIC01369
Description	Vibrio choleraeis was associated with IgA response.				[41]
Weissella confusa (firmicutes)			MIC01385
Description	Weissella spp.were selectively IgA+ (High IgA binding) coated in patients with inflammatory bowel disease (Crohn disease and ulcerative colitis).				[2]

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