Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00513)
MIC Name Dorea sp. (firmicutes)
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Dorea
Species: Dorea sp.
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Positive
Description Dorea is an obligate anaerobic, Gram-positive and nonspore-forming bacterial genus from the family Lachnospiraceae, which occurs in human faeces.
External Links Taxonomy ID
2040332
GOLD Organism ID
Go0546680
Disease Relevance
          Autism spectrum disorder  [ICD-11: 6A02]
             Description Dorea spp. was significantly elevated in autistic children. [1]
Host Genetic Factors (HGFs)
          MIR21
             HGF ID HGF2332 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of MIR-21 was significantly reduced the proportion of Dorea (p-value<0.05). [2]
          rs2241766
             HGF ID HGF1938 HGF Info       Class Single Nucleotide Polymorphism: Non coding transcript variant (SNP-NCTV)
             Description sensitization only in children with the rs10759932 TT genotype [3]
          rs12607607
             HGF ID HGF1630 HGF Info       Class Single Nucleotide Polymorphism: Upstream variant (SNP-UV)
             Description (adjusted odds ratio, 0.31; 95% CI, 0.14-0.68) and not in children [4]
          rs10865331
             HGF ID HGF2549 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs10865331 SNP is associated with the abundance of Dorea. [5]
          rs1847472
             HGF ID HGF2550 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1847472 SNP is associated with the abundance of Dorea. [5]
          rs566416
             HGF ID HGF2551 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs566416 SNP is associated with the abundance of Dorea. [5]
          rs254560
             HGF ID HGF2552 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs254560 SNP is associated with the abundance of Dorea. [5]
          rs3851228
             HGF ID HGF2553 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs3851228 SNP is associated with the abundance of Dorea. [5]
          rs2024092
             HGF ID HGF2554 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs2024092 SNP is associated with the abundance of Dorea. [5]
          rs2155219
             HGF ID HGF2555 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs2155219 SNP is associated with the abundance of Dorea. [5]
          rs7554511
             HGF ID HGF2556 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs7554511 SNP is associated with the abundance of Dorea. [5]
Host Immune Factors (HIFs)
          C-C motif chemokine 2
             HIF ID HIFM0022 HIF Info       Class Cytokine (Cyt)
             Description At the genus level, Dorea is associated with the MCP-1 expression. [6]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Dorea could cause the increased circulating levels of IL-6. [6]
          Neutrophils
             HIF ID HIFC0029 HIF Info       Class Granulocytes (Gra)
             Description Dorea spp. at neutrophil recovery was negatively correlated with subsequent acute severe graft-versus-host disease. [7]
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description Dorea was significantly enriched in the IgA(Low or no IgA binding) consortia. [8]
Environmental Factor(s)
             Disbiome ID
      236
             gutMDisorder ID
      gm0266
References
1 The Possible Role of the Microbiota-Gut-Brain-Axis in Autism Spectrum Disorder. Int J Mol Sci. 2019 Apr 29;20(9):2115. doi: 10.3390/ijms20092115.
2 Loss of MicroRNA-21 Influences the Gut Microbiota, Causing Reduced Susceptibility in a Murine Model of Colitis.J Crohns Colitis. 2018 Jun 28;12(7):835-848. doi: 10.1093/ecco-jcc/jjy038.
3 Variants in genes of innate immunity, appetite control and energy metabolism are associated with host cardiometabolic health and gut microbiota composition.Gut Microbes. 2020 May 3;11(3):556-568. doi: 10.1080/19490976.2019.1619440. Epub 2019 Jun 3.
4 Genetic Determinants of the Gut Microbiome in UK Twins.Cell Host Microbe. 2016 May 11;19(5):731-43. doi: 10.1016/j.chom.2016.04.017.
5 A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice. Genetics. 2020 Mar;214(3):719-733. doi: 10.1534/genetics.119.303013. Epub 2020 Jan 2.
6 Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced immunomodulation. Brain Behav Immun. 2011 Mar;25(3):397-407. doi: 10.1016/j.bbi.2010.10.023. Epub 2010 Oct 30.
7 Stool Microbiota at Neutrophil Recovery Is Predictive for Severe Acute Graft vs Host Disease After Hematopoietic Cell Transplantation.Clin Infect Dis. 2017 Nov 29;65(12):1984-1991. doi: 10.1093/cid/cix699.
8 IgA Function in Relation to the Intestinal Microbiota.Annu Rev Immunol. 2018 Apr 26;36:359-381. doi: 10.1146/annurev-immunol-042617-053238. Epub 2018 Jan 26.

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