Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0022)
HIF Name
C-C motif chemokine 2
HIF Synonym(s)
C-C motif chemokine ligand 2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF
HIF Classification
Cytokine (Cyt)
Molecular Function
Cytokine
Description Chemokines were originally described as cytokines that mediate leukocyte recruitment to sites of inflammation [1]
Pfam Small cytokines (intecrine/chemokine), interleukin-8 like (PF00048 )
Pathway AGE-RAGE signaling pathway in diabetic complications (hsa04933 )
Chagas disease (American trypanosomiasis) (hsa05142 )
Chemokine signaling pathway (hsa04062 )
Cytokine-cytokine receptor interaction (hsa04060 )
Fluid shear stress and atherosclerosis (hsa05418 )
Herpes simplex virus 1 infection (hsa05168 )
Human cytomegalovirus infection (hsa05163 )
IL-17 signaling pathway (hsa04657 )
Influenza A (hsa05164 )
Malaria (hsa05144 )
NOD-like receptor signaling pathway (hsa04621 )
Rheumatoid arthritis (hsa05323 )
TNF signaling pathway (hsa04668 )
Viral protein interaction with cytokine and cytokine receptor (hsa04061 )
Yersinia infection (hsa05135 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
CCL2_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Aggregatibacter aphrophilus (gamma-proteobacteria) MIC00052
             Description At the genus level, Aggregatibacter is associated with the CCL2 expression. [2]
         Bifidobacterium catenulatum (actinobacteria) MIC00211
             Description Bifidobacterium catenulatum is associated with the MCP-1 expression. [3]
         Bifidobacterium pseudocatenulatum (actinobacteria) MIC00219
             Description Bifidobacterium pseudocatenulatum could decrease MCP-1 expression. [4]
         Bordetella bronchiseptica (beta-proteobacteria) MIC00245
             Description Bordetella bronchiseptica is associated with the MCP-1 expression. [5]
         Campylobacter coli (epsilon-proteobacteria) MIC00301
             Description At the genus level, Campylobacter is associated with the MCP-1 expression. [6]
         Campylobacter jejuni (epsilon-proteobacteria) MIC00307
             Description Campylobacter jejuni is associated with the MCP-1 expression. [7]
         Chlamydia pneumoniae (chlamydias) MIC00350
             Description Chlamydophila pneumoniae could increase the MCP-1 expression. [8]
         Dorea sp. (firmicutes) MIC00513
             Description At the genus level, Dorea is associated with the MCP-1 expression. [9]
         Eggerthella lenta (actinobacteria) MIC00520
             Description At the genus level, Eggerthella is associated with the MCP-1 expression. [10]
         Klebsiella aerogenes (enterobacteria) MIC00530
             Description Enterobacter aerogenes is associated with the IMCP-1 expression. [11]
         Listeria monocytogenes (firmicutes) MIC00771
             Description Listeria monocytogenes is associated with the MCP-1 expression. [12]
         Pseudobutyrivibrio (firmicutes) MIC01050
             Description At the genus level, Pseudobutyrivibrio is associated with the MCP-1 expression. [9]
         Spirochaetes (bacteria) MIC01204
             Description At the genus level, oral Spirochaetes is associated with the MCP-1 expression. [13]
         Streptococcus gallolyticus (firmicutes) MIC01251
             Description Streptococcus gallolyticus could increase the CCL2 expression. [14]
         Ureaplasma parvum (mycoplasmas) MIC01359
             Description Ureaplasma parvum is associated with the MCP-1 expression. [15]
References
1 The CCL2/CCR2 Axis in the Pathogenesis of HIV-1 Infection: A New Cellular Target for Therapy. Curr Drug Targets. 2016;17(1):76-110. doi: 10.2174/138945011701151217110917.
2 Commensal and pathogenic biofilms differently modulate peri-implant oral mucosa in an organotypic model. Cell Microbiol. 2019 Oct;21(10):e13078. doi: 10.1111/cmi.13078. Epub 2019 Jul 17.
3 Immunostimulatory effect of faecal Bifidobacterium species of breast-fed and formula-fed infants in a peripheral blood mononuclear cell/Caco-2 co-culture system. Br J Nutr. 2011 Oct;106(8):1216-23. doi: 10.1017/S0007114511001656. Epub 2011 May 31.
4 Bifidobacterium pseudocatenulatum LI09 and Bifidobacterium catenulatum LI10 attenuate D-galactosamine-induced liver injury by modifying the gut microbiota. Sci Rep. 2017 Aug 18;7(1):8770. doi: 10.1038/s41598-017-09395-8.
5 Respiratory Bordetella bronchiseptica Carriage is Associated with Broad Phenotypic Alterations of Peripheral CD4+CD25+ T Cells and Differentially Affects Immune Responses to Secondary Non-Infectious and Infectious Stimuli in Mice. Int J Mol Sci. 2018 Sep 1;19(9):2602. doi: 10.3390/ijms19092602.
6 Oxidative and nitrosative stress defences of Helicobacter and Campylobacter species that counteract mammalian immunity. FEMS Microbiol Rev. 2016 Nov 1;40(6):938-960. doi: 10.1093/femsre/fuw025.
7 Protease Activity of Campylobacter jejuni HtrA Modulates Distinct Intestinal and Systemic Immune Responses in Infected Secondary Abiotic IL-10 Deficient Mice. Front Cell Infect Microbiol. 2019 Mar 29;9:79. doi: 10.3389/fcimb.2019.00079. eCollection 2019.
8 Chlamydia pneumoniae Infection and Inflammatory Diseases. For Immunopathol Dis Therap. 2016;7(3-4):237-254. doi: 10.1615/ForumImmunDisTher.2017020161.
9 Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced immunomodulation. Brain Behav Immun. 2011 Mar;25(3):397-407. doi: 10.1016/j.bbi.2010.10.023. Epub 2010 Oct 30.
10 Autoimmunity-Associated Gut Commensals Modulate Gut Permeability and Immunity in Humanized Mice. Mil Med. 2019 Mar 1;184(Suppl 1):529-536. doi: 10.1093/milmed/usy309.
11 Immunological cross-reactivity between Enterobacter aerogenes and Klebsiella capsular polysaccharides. Microb Pathog. 1990 Aug;9(2):127-30. doi: 10.1016/0882-4010(90)90086-6.
12 HDAC6 controls innate immune and autophagy responses to TLR-mediated signalling by the intracellular bacteria Listeria monocytogenes. PLoS Pathog. 2017 Dec 27;13(12):e1006799. doi: 10.1371/journal.ppat.1006799. eCollection 2017 Dec.
13 New insights into the emerging role of oral spirochaetes in periodontal disease. Clin Microbiol Infect. 2011 Apr;17(4):502-12. doi: 10.1111/j.1469-0691.2011.03460.x.
14 Streptococcus gallolyticus conspires myeloid cells to promote tumorigenesis of inflammatory bowel disease. Biochem Biophys Res Commun. 2018 Dec 2;506(4):907-911. doi: 10.1016/j.bbrc.2018.10.136. Epub 2018 Nov 2.
15 Different inflammatory responses are associated with Ureaplasma parvum-induced UTI and urolith formation. BMC Infect Dis. 2009 Jan 26;9:9. doi: 10.1186/1471-2334-9-9.

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