Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00301)
MIC Name Campylobacter coli (epsilon-proteobacteria)
MIC Synonyms Vibrio coli
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Epsilonproteobacteria
Order: Campylobacterales
Family: Campylobacteraceae
Genus: Campylobacter
Species: Campylobacter coli
Oxygen Sensitivity Microaerophile
Microbial Metabolism Strictly respiratory; Asaccharolytic
Gram Negative
Host Relationship Pathogen
Genome Size (bp) 1732548
No. of Coding Genes 1760
No. of Non-Coding Genes 54
No. of Small Non-Coding Genes 54
No. of Gene Transcripts 1814
No. of Base Pairs 1732548
Description Campylobacter coli is a microaerophilc, Gram negative bacterium. It is a thermophilic bacterial species that causes first watery, then inflammatory, diarrheal disease in humans.
External Links Taxonomy ID
195
Genome Assembly ID
ASM95419v1
GOLD Organism ID
Go0006389
Disease Relevance
          Inflammatory bowel disease  [ICD-11: DD72]
             Description Campylobacter was associated with inflammatory bowel disease. [1]
          Irritable bowel syndrome  [ICD-11: DD91]
             Description Infectious diarrhoea was caused by Campylobacter in humans. [2]
          Sepsis  [ICD-11: 1G41]
             Description Campylobacter coli can cause septicemia. [3]
Host Genetic Factors (HGFs)
          AMY1A
             HGF ID HGF2311 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description Oral microbiome Campylobacter differs between high AMY1-CN and low AMY1-CN groups at the OTU level (p-value<0.05). [4]
Host Immune Factors (HIFs)
          C-C motif chemokine 2
             HIF ID HIFM0022 HIF Info       Class Cytokine (Cyt)
             Description At the genus level, Campylobacter is associated with the MCP-1 expression. [5]
          C-X-C motif chemokine 9
             HIF ID HIFM0073 HIF Info       Class Cytokine (Cyt)
             Description Campylobacter which was among the gingivitis biomarkers in the MiG(Cxcl9) model. [6]
          Interferon-10
             HIF ID HIFM0128 HIF Info       Class Cytokine (Cyt)
             Description Campylobacter coli could increase the IL-10 expression. [7]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Campylobacter coli could increase the expression of IL-6. [7]
          C-X-C motif chemokine 8
             HIF ID HIFM0153 HIF Info       Class Cytokine (Cyt)
             Description Campylobacter coli could affect the expression of IL-8(p=0.013.) [7]
          Interferon gamma
             HIF ID HIFM0260 HIF Info       Class Cytokine (Cyt)
             Description An in vitro model of Campylobacter coli infection using healthy human gut explant showed marked induction of IFN-gamma with a modest increase of IL-22 and IL-17A levels. [7]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description At the genus level, Campylobacter is associated with TNF. [5]
Environmental Factor(s)
             Disbiome ID
      291
             gutMDisorder ID
      gm0142
References
1 The Clinical Importance of Campylobacter concisus and Other Human Hosted Campylobacter Species. Front Cell Infect Microbiol. 2018 Jul 24;8:243. doi: 10.3389/fcimb.2018.00243. eCollection 2018.
2 Ulcerative colitis and irritable bowel patients exhibit distinct abnormalities of the gut microbiota. BMC Gastroenterol. 2010 Nov 12;10:134. doi: 10.1186/1471-230X-10-134.
3 Comparison of Antimicrobial Susceptibility of Campylobacter Strains Isolated from Food Samples and Patients with Diarrhea. Iran Biomed J. 2016;20(2):91-6. doi: 10.7508/ibj.2016.02.004. Epub 2015 Nov 25.
4 Human Salivary Amylase Gene Copy Number Impacts Oral and Gut Microbiomes.Cell Host Microbe. 2019 Apr 10;25(4):553-564.e7. doi: 10.1016/j.chom.2019.03.001.
5 Oxidative and nitrosative stress defences of Helicobacter and Campylobacter species that counteract mammalian immunity. FEMS Microbiol Rev. 2016 Nov 1;40(6):938-960. doi: 10.1093/femsre/fuw025.
6 Predictive modeling of gingivitis severity and susceptibility via oral microbiota.ISME J. 2014 Sep;8(9):1768-80. doi: 10.1038/ismej.2014.32. Epub 2014 Mar 20.
7 Temporal induction of pro-inflammatory and regulatory cytokines in human peripheral blood mononuclear cells by Campylobacter jejuni and Campylobacter coli. PLoS One. 2017 Feb 14;12(2):e0171350. doi: 10.1371/journal.pone.0171350. eCollection 2017.

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