Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0153)
HIF Name
C-X-C motif chemokine 8
HIF Synonym(s)
C-X-C motif chemokine ligand 8, GCP-1, GCP1, IL8, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1, SCYB8
HIF Classification
Cytokine (Cyt)
Molecular Function
Cytokine
Description Chemokines are small proteins that control several tissue functions, including cell recruitment and activation under homeostatic and inflammatory conditions. CXCL8 (interleukin-8) is a member of the chemokine family that acts on CXCR1 and CXCR2 receptors. [1]
Pfam Small cytokines (intecrine/chemokine), interleukin-8 like (PF00048 )
Pathway AGE-RAGE signaling pathway in diabetic complications (hsa04933 )
Amoebiasis (hsa05146 )
Bladder cancer (hsa05219 )
Cellular senescence (hsa04218 )
Chagas disease (American trypanosomiasis) (hsa05142 )
Chemokine signaling pathway (hsa04062 )
Cytokine-cytokine receptor interaction (hsa04060 )
Epithelial cell signaling in Helicobacter pylori infection (hsa05120 )
Hepatitis B (hsa05161 )
Human cytomegalovirus infection (hsa05163 )
IL-17 signaling pathway (hsa04657 )
Influenza A (hsa05164 )
Kaposi sarcoma-associated herpesvirus infection (hsa05167 )
Legionellosis (hsa05134 )
Malaria (hsa05144 )
NF-kappa B signaling pathway (hsa04064 )
NOD-like receptor signaling pathway (hsa04621 )
Non-alcoholic fatty liver disease (NAFLD) (hsa04932 )
Pathogenic Escherichia coli infection (hsa05130 )
Pathways in cancer (hsa05200 )
Pertussis (hsa05133 )
Phospholipase D signaling pathway (hsa04072 )
RIG-I-like receptor signaling pathway (hsa04622 )
Rheumatoid arthritis (hsa05323 )
Salmonella infection (hsa05132 )
Shigellosis (hsa05131 )
Toll-like receptor signaling pathway (hsa04620 )
Transcriptional misregulation in cancer (hsa05202 )
Viral protein interaction with cytokine and cytokine receptor (hsa04061 )
Yersinia infection (hsa05135 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
IL8_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Aggregatibacter aphrophilus (gamma-proteobacteria) MIC00052
             Description Aggregatibacter is associated with IL-8 expression. [2]
         Akkermansia muciniphila (verrucomicrobia) MIC00056
             Description Akkermansia muciniphila induced higher expression level of IL-8. [3]
         Atopobium vaginae (actinobacteria) MIC00110
             Description IL-8 was secreted by vaginal epithelial cells in response to the activity of Atopobium vaginae. [4]
         Bifidobacterium breve (actinobacteria) MIC00210
             Description Brucella canis is associated with IL-8. [5]
         Burkholderia cenocepacia (beta-proteobacteria) MIC00280
             Description The expression of IL-8 upregulated in alveolar epithelial cells after infection Burkholderia cenocepacia. [6]
         Butyricicoccus pullicaecorum (firmicutes) MIC00293
             Description Supernatant of Butyricicoccus pullicaecorum prevented the increase in IL-8 secretion induced by TNF-alpha and interferon-gamma. [7]
         Campylobacter coli (epsilon-proteobacteria) MIC00301
             Description Campylobacter coli could affect the expression of IL-8(p=0.013.) [8]
         Chlamydia pneumoniae (chlamydias) MIC00350
             Description Chlamydophila pneumoniae could increase the expression of IL-8. [9]
         Chlamydia trachomatis (chlamydias) MIC00344
             Description IL-8 secretion by ECC-1 cells increased in response to live and heat-killed Chlamydia trachomatis. [10]
         Clostridioides difficile (firmicutes) MIC00396
             Description Clostridium difficile toxin induced the production of IL-8. [11]
         Clostridium sporosphaeroides (firmicutes) MIC00421
             Description IL-8 production in peripheral blood mononuclear cells was most efficiently stimulated by Clostridium sporosphaeroides. [12]
         Corynebacterium amycolatum (actinobacteria) MIC00450
             Description Corynebacterium amycolatum stimulated high IL-8 production. [13]
         Cronobacter sakazakii (enterobacteria) MIC00469
             Description The Cronobacter sakazakii-infected tissues secreted IL-8. [14]
         Desulfovibrio desulfuricans (delta-proteobacteria) MIC00495
             Description Desulfovibrio desulfuricans-derived lipopolysaccharides stimulated the release of IL-8 from endothelial cell. [15]
         Eikenella corrodens (beta-proteobacteria) MIC00525
             Description A slight stimulation of the IL-8 mRNA levels was seen when Eikenella corrodens was separated from KB cells by cell culture inserts. [16]
         Faecalibacterium prausnitzii (firmicutes) MIC00590
             Description Faecalibacterium prausnitzii is associated with IL-8. [17]
         Glaesserella parasuis (gamma-proteobacteria) MIC00654
             Description The cytokines interleukin (IL)-8 can participate in the inflammatory response to Haemophilus parasuis. [18]
         Granulicatella adiacens (firmicutes) MIC00645
             Description Granulicatella is positive correlation with IL-8 expression. [19]
         Haemophilus ducreyi (gamma-proteobacteria) MIC00650
             Description Haemophilus ducreyi stimulated secretion of IL-8 by keratinocytes. [20]
         Klebsiella aerogenes (enterobacteria) MIC00530
             Description Enterobacter aerogenes is associated with IL-8 expression. [21]
         Lactobacillus acidophilus (firmicutes) MIC00702
             Description The gene expression of IL8 in IECs was decreased by Lactobacillus acidophilus infection. [22]
         Lactobacillus crispatus (firmicutes) MIC00710
             Description Lactobacillus crispatus and its supernatant reduced IL-8 production in Chlamydia trachomatis-infected HeLa and J774 cells. [23]
         Lactobacillus gallinarum (firmicutes) MIC00715
             Description Lactobacillus gallinarum strains might possess an immunomodulatory component, which suppresses IL-8 secretion. [24]
         Lactobacillus jensenii (firmicutes) MIC00720
             Description Lactobacillus jensenii TL2937 was the strain with the highest capacity to down-regulate IL-8 production. [25]
         Leptotrichia goodfellowii (fusobacteria) MIC00762
             Description Leptotrichia could trigger the transcription expression level of IL-8. [26]
         Methylorubrum extorquens (alpha-proteobacteria) MIC00814
             Description The gene encoding IL-8 was up-regulated during Methylobacterium oryzae infection. [27]
         Mycobacterium leprae (actinobacteria) MIC00851
             Description Mycobacterium leprae is associated with CXCL8 expression. [28]
         Mycobacterium ulcerans (actinobacteria) MIC00852
             Description Mycobacterium marinum induce higher production of important chemok-ines such as CXCL8. [29]
         Mycobacterium sp. (actinobacteria) MIC00855
             Description ML1899 conserved in all mycobacterium sp. could up-regulated the expression of IL-8. [30]
         Mycoplasma genitalium (mycoplasmas) MIC00870
             Description There is no statistically significant differences in the levels of IL-8(p>0.05)in the Mollicutes infection with the health. [31]
         Prevotella bivia (CFB bacteria) MIC01007
             Description The increased IL8 levels in cervicovaginal fluid associated with the Prevotella bivia colonization. [32]
         Prevotella nanceiensis (CFB bacteria) MIC01018
             Description Prevotella nanceiensis could decrease the expression of IL-8. [32]
         Prevotella pallens (CFB bacteria) MIC01022
             Description Prevotella pallens could decrease the level of IL-8. [33]
         Shigella sonnei (enterobacteria) MIC01183
             Description Shigella sonnei could reduce pro-inflammatory immune responses such as IL-8. [34]
         Spirochaetes (bacteria) MIC01204
             Description Spirochaetes is associated with IL-8 expression. [35]
         Streptococcus gallolyticus (firmicutes) MIC01251
             Description Streptococcus gallolyticus could increase the expression of IL-8. [36]
         Streptococcus intermedius (firmicutes) MIC01255
             Description Streptococcus intermedius could induce the IL-8 expression. [37]
         Streptococcus salivarius (firmicutes) MIC01268
             Description Streptococcus salivarius released a low-molecular-weight soluble factors that significantly reduced the activation of IL-8 secretion in intestinal epithelial and immune cell lines. [38]
         Streptococcus thermophilus (firmicutes) MIC01272
             Description Chemokine CXCL8 is upregulated (11.26 0.27 fold )following Streptococcus thermophilus culture. [39]
         Streptococcus uberis (firmicutes) MIC01274
             Description The milk concentrations of IL-8 was elevated after challenged with Streptococcus uberis. [40]
         Streptomyces griseus (actinobacteria) MIC01280
             Description Streptomyces griseus chitinase showed higher level of IL-8 protein production and mRNA expression through chitinase enzymatic activity. [41]
         Tannerella forsythia (CFB bacteria) MIC01305
             Description Tannerella forsythia monocytes could produced IL-8. [42]
         Treponema lecithinolyticum (spirochaetes) MIC01323
             Description Treponema lecithinolyticum activated human monocytes and PDL cells to induce production of proinflammatory cytokines, such as IL-8. [43]
         Treponema maltophilum (spirochaetes) MIC01324
             Description Treponema maltophilum activated human monocytes and PDL cells to induce production of proinflammatory cytokines, such as IL-8. [43]
         Treponema socranskii (spirochaetes) MIC01326
             Description Treponema socranskii is associated with IL-8 expression. [44]
         Trueperella pyogenes (actinobacteria) MIC01335
             Description Trueperella pyogenes is associated with IL-8 expression. [45]
References
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4 Atopobium vaginae triggers an innate immune response in an in vitro model of bacterial vaginosis. Microbes Infect. 2008 Apr;10(4):439-46. doi: 10.1016/j.micinf.2008.01.004. Epub 2008 Jan 12.
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8 Temporal induction of pro-inflammatory and regulatory cytokines in human peripheral blood mononuclear cells by Campylobacter jejuni and Campylobacter coli. PLoS One. 2017 Feb 14;12(2):e0171350. doi: 10.1371/journal.pone.0171350. eCollection 2017.
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17 Association Between Gut Microbiota and CD4 Recovery in HIV-1 Infected Patients. Front Microbiol. 2018 Jul 2;9:1451. doi: 10.3389/fmicb.2018.01451. eCollection 2018.
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