Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00344)
MIC Name Chlamydia trachomatis (chlamydias)
MIC Synonyms Rickettsia trachomatis
Body Site Mucosa
Lineage Kingdom: Bacteria
Phylum: Chlamydiae
Class: Chlamydiia
Order: Chlamydiales
Family: Chlamydiaceae
Genus: Chlamydia
Species: Chlamydia trachomatis
Oxygen Sensitivity Obligate aerobe
Microbial Metabolism Respiratory
Gram Negative
Genome Size (bp) 1042588
No. of Coding Genes 923
No. of Non-Coding Genes 43
No. of Small Non-Coding Genes 43
No. of Gene Transcripts 966
No. of Base Pairs 1042588
Description Chlamydia trachomatis, commonly known as chlamydia, is a bacterium that causes chlamydia, which can manifest in various ways, including: trachoma, lymphogranuloma venereum, nongonococcal urethritis, cervicitis, salpingitis, pelvic inflammatory disease. C. trachomatis is the most common infectious cause of blindness and the most common sexually transmitted bacterium.
External Links Taxonomy ID
813
Genome Assembly ID
ASM59057v1
GOLD Organism ID
Go0518641
Disease Relevance
          Vaginitis  [ICD-11: GA02]
             Description Chlamydia trachomatis was associated with bacterial vaginosis. [1]
Host Genetic Factors (HGFs)
          hsa-miR-184
             HGF ID HGF0657 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of miR-184 was significantly down-regulated during follicular trachoma in the absence of Chlamydia trachomatis (p-value<0.05). [2]
          hsa-miR-147b-5p
             HGF ID HGF0651 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of miR-147b was significantly up-regulated in inflammatory trachomatous scarring with Chlamydia trachomatis infection (p-value<0.05). [2]
          hsa-miR-1285-3p
             HGF ID HGF0274 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of miR-1285-3p was significantly up-regulated in inflammatory trachomatous scarring with Chlamydia trachomatis infection (p-value<0.05). [2]
          hsa-miR-155-5p
             HGF ID HGF0243 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of miR-155 was significantly up-regulated during Chlamydia trachomatis infection (p-value<0.05). [2]
          rs3922
             HGF ID HGF1838 HGF Info       Class Single Nucleotide Polymorphism: Prime UTR variant (SNP-PV)
             Description Women who developed tubal pathology after a Chlamydia trachomatis infection had a decrease in the frequency of CXCR5 SNP +10950 T>C (rs3922). [3]
Host Immune Factors (HIFs)
          Human beta-defensin 1
             HIF ID HIFM0090 HIF Info       Class Antimicrobial peptide (AMP)
             Description Chlamydia trachomatis induced variable increases of hBD-1 concentration. [4]
          C-X-C motif chemokine 8
             HIF ID HIFM0153 HIF Info       Class Cytokine (Cyt)
             Description IL-8 secretion by ECC-1 cells increased in response to live and heat-killed Chlamydia trachomatis. [5]
          Immunoglobulin G1
             HIF ID HIFM0269 HIF Info       Class Immunoglobulin (Ig)
             Description Chlamydia trachomatis was associated with IgG1 response. [6]
          THP-1 monocytes
             HIF ID HIFC0214 HIF Info       Class Monocytes (Mono)
             Description The wild-type (WT) THP-1 cells were infected with Chlamydia trachomatis for 24 h, they secreted significantly less IL-1 and activated caspase-1 into the supernatant, confirming that Chlamydia-induced IL-1 secretion relies on caspase-1 activation(p<0.05). [7]
          NETosis signaling pathway
             HIF ID HIFP0027 HIF Info       Class Signaling pathway (SP)
             Description At the species level, Chlamydia trachomatis is associated with NETosis [5]
Environmental Factor(s)
             Disbiome ID
      508
References
1 The two-sided role of the vaginal microbiome in Chlamydia trachomatis and Mycoplasma genitalium pathogenesis. J Reprod Immunol. 2018 Nov;130:11-17. doi: 10.1016/j.jri.2018.08.006. Epub 2018 Aug 22.
2 miRNAs that associate with conjunctival inflammation and ocular Chlamydia trachomatis infection do not predict progressive disease. Pathog Dis. 2017 Mar 1;75(2):ftx016. doi: 10.1093/femspd/ftx016.
3 Interruption of CXCL13-CXCR5 axis increases upper genital tract pathology and activation of NKT cells following chlamydial genital infection.PLoS One. 2012;7(11):e47487. doi: 10.1371/journal.pone.0047487. Epub 2012 Nov 26.
4 [HBD-1 and hBD-2 are expressed in cervico-vaginal lavage in female genital tract due to microbial infections].Ginekol Pol. 2010 Apr;81(4):268-71.
5 Chlamydia trachomatis regulates innate immune barrier integrity and mediates cytokine and antimicrobial responses in human uterine ECC-1 epithelial cells. Am J Reprod Immunol. 2017 Dec;78(6). doi: 10.1111/aji.12764. Epub 2017 Sep 16.
6 IgG subclass antibodies to human and bacterial HSP60 are not associated with disease activity and progression over time in axial spondyloarthritis.Arthritis Res Ther. 2013;15(3):R61. doi: 10.1186/ar4234.
7 Chlamydial infection of monocytes stimulates IL-1beta secretion through activation of the NLRP3 inflammasome.Microbes Infect. 2010 Aug;12(8-9):652-661. doi: 10.1016/j.micinf.2010.04.008. Epub 2010 Apr 29.

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