General Information of HIF (ID: HIFM0269)
HIF Name	Immunoglobulin G1
HIF Synonym(s)	IgG1
HIF Classification	Immunoglobulin (Ig)
Description	Immunoglobulin G1(IgG1) is one of four Immunoglobulin G subclasses.It mediates the response to proteic antigens and have a major ability to bind to the cells that mediate the immune response.				[1]

Microbe Species (MIC) Regulated by This HIF
Actinobacillus pleuropneumoniae (gamma-proteobacteria)			MIC00026
Description	The abundance of Actinobacillus pleuropneumoniae is associated with IgG1 response.				[2]
Akkermansia muciniphila (verrucomicrobia)			MIC00056
Description	Akkermansia muciniphila induced IgG1 antibodies response.				[3]
Bacteroides fragilis (CFB bacteria)			MIC00158
Description	IgG1 could be against Bacteroides fragilis.				[4]
Brachyspira hyodysenteriae (spirochaetes)			MIC00258
Description	Brachyspira infection could increase antigen-specific IgG1 responses to the resident microflora.				[5]
Campylobacter jejuni (epsilon-proteobacteria)			MIC00307
Description	Campylobacter jejuni infection induced production of IgG1 autoantibodies against ganglioside GM1 and caused complement-mediated motor nerve injury.				[6]
Capnocytophaga ochracea (CFB bacteria)			MIC00328
Description	The activity of proteolytic enzymes from Capnocytophaga ochracea could effect enzymolysis of human immunoglobulin G1(lgG1).				[7]
Chlamydia trachomatis (chlamydias)			MIC00344
Description	Chlamydia trachomatis was associated with IgG1 response.				[8]
Erysipelothrix rhusiopathiae (firmicutes)			MIC00559
Description	The abundance of Erysipelothrix is associated with IgG1 response.				[9]
Escherichia coli (enterobacteria)			MIC00516
Description	Immunoglobulin G1 decreases the abundance of Escherichia coli.				[4]
Glaesserella parasuis (gamma-proteobacteria)			MIC00654
Description	The abundance of Haemophilus influenzae is associated with IgG1 response.				[10]
Haemophilus sp. (gamma-proteobacteria)			MIC01768
Description	Haemophilus sp. is associated with IgG1 response.				[10]
Helicobacter bilis (epsilon-proteobacteria)			MIC00663
Description	Helicobacter bilis infection could increase antigen-specific IgG1 responses to the resident microflora.				[5]
Helicobacter cinaedi (epsilon-proteobacteria)			MIC00665
Description	IgG1 could response to Helicobacter cinaedi infection.				[11]
Histophilus somni (gamma-proteobacteria)			MIC00655
Description	The abundance of Histophilus somni is associated with IgG1.				[12]
Lactobacillus paracasei (firmicutes)			MIC00726
Description	The infection of Lactobacillus paracasei could increase the levels of IgG1.				[13]
Mycobacterium avium (actinobacteria)			MIC00846
Description	IgG1 antibodies against Mycobacterium avium subsp.paratuberculosis protein p34-cx improved association of bacteria and macrophages.				[14]
Mycobacterium leprae (actinobacteria)			MIC00851
Description	Disease progression in leprosy caused by Mycobacterium leprae showed a significant correlation with selective increases in IgG1 responses.				[15]
Neisseria lactamica (beta-proteobacteria)			MIC00888
Description	Significantly higher titers (p = < 0.05) of OVA-specific IgG1 were induced by alum and by Neisseria lactamica PorB as compared to OVA alone.				[16]
Neisseria meningitidis (beta-proteobacteria)			MIC00891
Description	IgG1 could response to Meningococcus.				[10]
Porphyromonas gingivalis (CFB bacteria)			MIC01000
Description	The activity of proteolytic enzymes from Porphyromonas gingivalis could effect enzymolysis of human immunoglobulin G1(lgG1).				[7]
Rickettsia prowazekii (alpha-proteobacteria)			MIC01108
Description	Specific IgG1 could be detected at day 7 and increased up to day 21 during R. prowazekii infection.				[17]
Roseburia faecis (firmicutes)			MIC01116
Description	Prediagnosis IgG2 titers could be against the Roseburia faecis strain.				[18]
Saccharomyces cerevisiae (budding yeasts)			MIC01145
Description	IgG1 could be against Saccharomyces cerevisiae.				[4]
Salmonella enterica subsp. enterica (enterobacteria)			MIC01154
Description	The infection of Salmonella typhimurium could increase the levels of IgG1.				[19]
Salmonella sp. (enterobacteria)			MIC01149
Description	Salmonella was associated with IgG1 response.				[20]
Staphylococcus aureus (firmicutes)			MIC01208
Description	The abundance of Staphylococcus aureus is associated with IgG1 response.				[21]
Streptobacillus moniliformis (fusobacteria)			MIC01235
Description	Streptobacillus moniliformis was associated with IgG2b response.				[22]
Streptococcus gallolyticus (firmicutes)			MIC01251
Description	Prediagnosis IgG2 titers could be against the Streptococcus gallolyticus strain.				[18]
Streptococcus pneumoniae (firmicutes)			MIC01263
Description	IgG1 could response to the choline-binding protein PspC of Streptococcus pneumoniae.				[23]
Streptococcus sp. (firmicutes)			MIC01276
Description	IgG1 could be against streptococcus.				[24]
Vibrio cholerae (gamma-proteobacteria)			MIC01369
Description	Vibrio cholerae was associated with IgG1 response.				[25]
Yersinia pestis (enterobacteria)			MIC01401
Description	Yersinia pestis was associated with IgG1 response.				[26]

References
1	[IgG subclasses and their clinical significance].Minerva Pediatr. 1990 Dec;42(12):509-14.
2	Anti-haemolysin IgG1 to IgG2 ratios correlate with haemolysin neutralization titres and lung lesion scores in Actinobacillus pleuropneumoniae infected pigs.Vaccine. 1998 Dec;16(20):1971-5. doi: 10.1016/s0264-410x(98)00120-0.
3	Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis.Science. 2019 Jun 21;364(6446):1179-1184. doi: 10.1126/science.aaw7479.
4	Anti-food and anti-microbial IgG subclass antibodies in inflammatory bowel disease.Scand J Gastroenterol. 2016 Dec;51(12):1453-1461. doi: 10.1080/00365521.2016.1205130. Epub 2016 Jul 25.
5	Induction of differential immune reactivity to members of the flora of gnotobiotic mice following colonization with Helicobacter bilis or Brachyspira hyodysenteriae. Microbes Infect. 2006 May;8(6):1602-10. doi: 10.1016/j.micinf.2006.01.019. Epub 2006 Apr 18.
6	On-Membrane Dynamic Interplay between Anti-GM1 IgG Antibodies and Complement Component C1q.Int J Mol Sci. 2019 Dec 24;21(1):147. doi: 10.3390/ijms21010147.
7	Immunoglobulin-degrading enzymes in localized juvenile periodontitis.J Periodontal Res. 1992 May;27(3):176-83. doi: 10.1111/j.1600-0765.1992.tb01666.x.
8	IgG subclass antibodies to human and bacterial HSP60 are not associated with disease activity and progression over time in axial spondyloarthritis.Arthritis Res Ther. 2013;15(3):R61. doi: 10.1186/ar4234.
9	IgGs containing - and -type light chains and of all subclasses (IgG1-IgG4) from the sera of patients with autoimmune diseases and viral and bacterial infections hydrolyze DNA.J Mol Recognit. 2012 Jul;25(7):383-92. doi: 10.1002/jmr.2185.
10	Are there any clinical indications for measuring IgG subclasses. Ann Clin Biochem. 2002 Jul;39(Pt 4):374-7. doi: 10.1258/000456302760042678.
11	Alkyl hydroperoxide reductase is required for Helicobacter cinaedi intestinal colonization and survival under oxidative stress in BALB/c and BALB/c interleukin-10-/- mice. Infect Immun. 2012 Mar;80(3):921-8. doi: 10.1128/IAI.05477-11. Epub 2011 Dec 19.
12	Experimental abortion and the systemic immune response to "Haemophilus somnus" in cattle. Infect Immun. 1986 Nov;54(2):555-60.
13	Consumption of Dairy Yogurt Containing Lactobacillus paracasei ssp. paracasei, Bifidobacterium animalis ssp. lactis and Heat-Treated Lactobacillus plantarum Improves Immune Function Including Natural Killer Cell Activity. Nutrients. 2017 May 31;9(6):558. doi: 10.3390/nu9060558.
14	Bovine IgG1 antibodies against Mycobacterium avium subsp. paratuberculosis protein p34-cx improve association of bacteria and macrophages.Vet Res. 2008 Jan-Feb;39(1):6. doi: 10.1051/vetres:2007043. Epub 2007 Nov 9.
15	Immunoglobulin G1 (IgG1) and IgG3 antibodies are markers of progressive disease in leprosy.Infect Immun. 1995 Feb;63(2):410-5. doi: 10.1128/IAI.63.2.410-415.1995.
16	The PorB porin from commensal Neisseria lactamica induces Th1 and Th2 immune responses to ovalbumin in mice and is a potential immune adjuvant. Vaccine. 2008 Feb 6;26(6):786-96. doi: 10.1016/j.vaccine.2007.11.080. Epub 2007 Dec 26.
17	A murine model of infection with Rickettsia prowazekii: implications for pathogenesis of epidemic typhus. Microbes Infect. 2007 Jun;9(7):898-906. doi: 10.1016/j.micinf.2007.03.008. Epub 2007 Mar 21.
18	Association of HLA-dependent islet autoimmunity with systemic antibody responses to intestinal commensal bacteria in children.Sci Immunol. 2019 Feb 1;4(32):eaau8125. doi: 10.1126/sciimmunol.aau8125.
19	Salmonella Typhimurium, the major causative agent of foodborne illness inactivated by a phage lysis system provides effective protection against lethal challenge by induction of robust cell-mediated immune responses and activation of dendritic cells. Vet Res. 2017 Oct 25;48(1):66. doi: 10.1186/s13567-017-0474-x.
20	Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens.Immunity. 2016 Mar 15;44(3):647-658. doi: 10.1016/j.immuni.2016.02.006. Epub 2016 Mar 2.
21	Specificity of staphylococcal superantigen-like protein 10 toward the human IgG1 Fc domain.J Immunol. 2010 Jun 1;184(11):6283-92. doi: 10.4049/jimmunol.0903311. Epub 2010 Apr 28.
22	Comparative analysis of clinics, pathologies and immune responses in BALB/c and C57BL/6 mice infected with Streptobacillus moniliformis. Microbes Infect. 2018 Feb;20(2):101-110. doi: 10.1016/j.micinf.2017.10.001. Epub 2017 Oct 10.
23	Genome-wide association study of IgG1 responses to the choline-binding protein PspC of Streptococcus pneumoniae.Genes Immun. 2015 Jul-Aug;16(5):289-96. doi: 10.1038/gene.2015.12. Epub 2015 Apr 30.
24	Distinct IgG1 and IgG3 subclass responses to two streptococcal protein antigens in man: analysis of antibodies to streptolysin O and M protein using standardized subclass-specific enzyme-linked immunosorbent assays.Immunology. 1993 May;79(1):89-94.
25	Plant-based production of two chimeric monoclonal IgG antibodies directed against immunodominant epitopes of Vibrio cholerae lipopolysaccharide.J Immunol Methods. 2015 Jul;422:111-7. doi: 10.1016/j.jim.2015.04.001. Epub 2015 Apr 9.
26	Induction of Protective Antiplague Immune Responses by Self-Adjuvanting Bionanoparticles Derived from Engineered Yersinia pestis. Infect Immun. 2020 Apr 20;88(5):e00081-20. doi: 10.1128/IAI.00081-20. Print 2020 Apr 20.

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