Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01000)
MIC Name Porphyromonas gingivalis (CFB bacteria)
MIC Synonyms Bacteroides gingivalis
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Porphyromonadaceae
Genus: Porphyromonas
Species: Porphyromonas gingivalis
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Asaccharolytic; Proteolytic; Fermentative
Gram Negative
Host Relationship Pathogen
Genome Size (bp) 2354886
No. of Coding Genes 1958
No. of Non-Coding Genes 66
No. of Small Non-Coding Genes 66
No. of Gene Transcripts 2024
No. of Base Pairs 2441780
Description Porphyromonas gingivalis is a nonmotile, Gram-negative, rod-shaped, anaerobic, pathogenic bacterium belongs to the phylum Bacteroidetes. It is found in the oral cavity, where it is implicated in periodontal disease, as well as in the upper gastrointestinal tract, the respiratory tract and the colon. It has been isolated from women with bacterial vaginosis.
External Links Taxonomy ID
837
Genome Assembly ID
ASM73941v1
GOLD Organism ID
Go0000614
Disease Relevance
          Periodontal disease  [ICD-11: DA0C]
             Description A small number of Porphyromonas gingivalis had been consistently associated with periodontitis. [1]
          Vaginitis  [ICD-11: GA02]
             Description Porphyromonas gingivalis was associated with bacterial vaginosis. [2]
Host Genetic Factors (HGFs)
          mmu-miR-8109
             HGF ID HGF1073 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The mmu-miR-8109 expression was downregulated 3.3-fold with Porphyromonas gingivalis infection. [3]
          mmu-miR-7674-5p
             HGF ID HGF1072 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The mmu-miR-7674-5p expression was upregulated 27.3-fold with Porphyromonas gingivalis infection. [3]
          mmu-miR-6975-5p
             HGF ID HGF1071 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The mmu-miR-6975-5p expression was upregulated 4.4-fold with Porphyromonas gingivalis infection. [3]
          mmu-miR-3473e
             HGF ID HGF1070 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The mmu-miR-3473e expression was upregulated 2.7-fold with Porphyromonas gingivalis infection. [3]
          mmu-miR-3473b
             HGF ID HGF1069 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The mmu-miR-3473b expression was upregulated 2.7-fold with Porphyromonas gingivalis infection. [3]
          mmu-miR-2137
             HGF ID HGF1068 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The mmu-miR-2137 expression was downregulated 3.2-fold with Porphyromonas gingivalis infection. [3]
          mmu-miR-211-3p
             HGF ID HGF1067 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The mmu-miR-211-3p expression was downregulated 2.4-fold with Porphyromonas gingivalis infection. [3]
          mmu-miR-155-5p
             HGF ID HGF1066 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The mmu-miR-155-5p expression was upregulated 5.4-fold with Porphyromonas gingivalis infection. [3]
          hsa-miR-139-3p
             HGF ID HGF0585 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-139-3p was 4-fold up-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-935
             HGF ID HGF0579 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-935 was 2-fold up-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-802
             HGF ID HGF0577 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-802 was 2-fold up-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-662
             HGF ID HGF0574 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-662 was 2-fold down-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-650
             HGF ID HGF0572 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-650 was 1-fold down-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-648
             HGF ID HGF0571 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-648 was 2-fold down-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-620
             HGF ID HGF0570 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-620 was 2-fold down-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-575
             HGF ID HGF0567 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-575 was 1-fold down-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-556-3p
             HGF ID HGF0565 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-556-3p was 2-fold up-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-548n
             HGF ID HGF0564 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-548n was 2-fold down-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-548a-5p
             HGF ID HGF0561 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-548a-5p was 2-fold down-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-512-3p
             HGF ID HGF0559 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-512-3p was 3-fold down-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-498-5p
             HGF ID HGF0558 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-498-5p was 2-fold down-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-375-5p
             HGF ID HGF0543 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-375-5p was 2-fold up-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-372-5p
             HGF ID HGF0542 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-372-5p was 2-fold down-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-206
             HGF ID HGF0533 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-206 was 2-fold down-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-1322
             HGF ID HGF0531 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-1322 was 3-fold down-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-1305
             HGF ID HGF0530 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-1305 expression was down-regulated 4-fold by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-1282
             HGF ID HGF0529 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-1282 was 3-fold down-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-1262
             HGF ID HGF0527 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-1262 was 3-fold down-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-1252-5p
             HGF ID HGF0526 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-1252-5p was 4-fold down-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-1225-3p
             HGF ID HGF0525 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-1225-3p was 3-fold up-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-let-7f-5p
             HGF ID HGF0297 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of let-7f expression was significantly upregulated with Porphyromonas gingivalis infection (p-value<0.05). [5]
          hsa-miR-106a-5p
             HGF ID HGF0288 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-106a-5p was 1-fold down-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-1247-5p
             HGF ID HGF0281 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-1247-5p was 4-fold up-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-1277-3p
             HGF ID HGF0275 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-1277-3p was 3-fold up-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-128-3p
             HGF ID HGF0273 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-128-3p was 2-fold up-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-130b-3p
             HGF ID HGF0269 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-130b-3p was 2-fold down-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-132-3p
             HGF ID HGF0267 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-132 expression was inhibited by Porphyromonas gingivalis alonely. [6]
          hsa-miR-141-3p
             HGF ID HGF0259 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-141-3p was 4-fold up-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-143-3p
             HGF ID HGF0258 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-143-3p was 3-fold up-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-146a-5p
             HGF ID HGF0252 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-146a expression is associated with the abundance of Porphyromonas gingivalis (p-value<0.05). [6]
          hsa-miR-146b-5p
             HGF ID HGF0251 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-146b expression was 4-fold up-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-154-5p
             HGF ID HGF0244 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-154-5p was 4-fold down-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-155-5p
             HGF ID HGF0243 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-155 expression is associated with the abundance of Porphyromonas gingivalis (p-value<0.05). [6]
          hsa-miR-216a-5p
             HGF ID HGF0199 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-216a-5p was 2-fold down-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-26a-1-3p
             HGF ID HGF0184 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-26a-1-3p was 4-fold up-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-29b-3p
             HGF ID HGF0177 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-29b expression was significantly down-regulated by Porphyromonas gingivalis (p-value<0.05). [5]
          hsa-miR-380-3p
             HGF ID HGF0138 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-380-3p was 3-fold down-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-378a-3p
             HGF ID HGF0134 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-378a-3p was 3-fold down-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-493-3p
             HGF ID HGF0122 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-493-3p was 2-fold up-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-501-5p
             HGF ID HGF0118 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-501-5p was 3-fold down-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-503-5p
             HGF ID HGF0117 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-503-5p was 3-fold up-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-506-3p
             HGF ID HGF0115 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-506-3p was 2-fold up-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-508-3p
             HGF ID HGF0114 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-508-3p was 3-fold down-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-517c-3p
             HGF ID HGF0112 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-517c-3p was 3-fold down-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-518c-3p
             HGF ID HGF0111 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-518c-3p was 4-fold up-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-524-5p
             HGF ID HGF0109 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-524-5p was 3-fold down-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-548a-3p
             HGF ID HGF0106 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-548a-3p was 3-fold down-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-548b-3p
             HGF ID HGF0105 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-548b-3p was 3-fold up-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-570-3p
             HGF ID HGF0104 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-570-3p was 3-fold up-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-873-5p
             HGF ID HGF0091 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-873-5p was 5-fold up-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          hsa-miR-92a-1-5p
             HGF ID HGF0088 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-92a-1-5p was 3-fold down-regulation by Porphyromonas gingivalis in human gingival fibroblasts. [4]
          rs6940
             HGF ID HGF1734 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description Haplotype blocks rs6940 was ignificantly associated with increased extent bleeding on probing and levels of microorganisms Porphyromonas gingivalis (p0.05). [7]
          rs2737190
             HGF ID HGF1970 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description Combined with Porphyromonas gingivalis infection, rs2737190 (GG/AA+AG) were independent risk factors of chronic periodontitis (p-value=0.004). [8]
          rs2149356
             HGF ID HGF1281 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description Combined with Porphyromonas gingivalis infection, rs2149356 (TT/GG+GT) were independent risk factors of chronic periodontitis (p-value=0.002). [8]
          rs1927911
             HGF ID HGF1283 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description Combined with Porphyromonas gingivalis infection, rs1927911 (TT/CC+CT) were independent risk factors of chronic periodontitis (p-value=0.004). [8]
          rs1057028
             HGF ID HGF1735 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description Haplotype blocks rs1057028 was ignificantly associated with increased extent bleeding on probing and levels of microorganisms Porphyromonas gingivalis (p0.05). [7]
          rs1039559
             HGF ID HGF1275 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1039559 SNP was significantly associated with the abundance of Porphyromonas gingivalis (p-value=0.001). [9]
Host Immune Factors (HIFs)
          Retinoic acid receptor responder protein2
             HIF ID HIFM0196 HIF Info       Class Antimicrobial peptide (AMP)
             Description Gingipains secreted by the periodontopathogen Porphyromonas gingivalis inactivate chemerin. [10]
          Human neutrophil peptide-2
             HIF ID HIFM0306 HIF Info       Class Antimicrobial peptide (AMP)
             Description Overexpression of human neutrophil peptide-2(HNP2) defensins against Porphyromonas gingivalis infection of human OSCC samples and of OSCC cells (BHY line). [11]
          Interleukin-1 beta
             HIF ID HIFM0138 HIF Info       Class Cytokine (Cyt)
             Description Porphyromonas gingivalis is associated with IL-1beta expression. [12]
          C-X-C Motif Chemokine Ligand 12
             HIF ID HIFM0207 HIF Info       Class Cytokine (Cyt)
             Description Porphyromonas gingivalis infection decrease the CXCL12 expression in gingival fibroblasts. [13]
          Monocyte-derived dendritic cells
             HIF ID HIFC0004 HIF Info       Class Dendritic cells (DCs)
             Description Expression of Porphyromonas gingivalis mfa1 fimbriae was increased in Monocyte-derived dendritic cells of periodontitis patients. [14]
          Immunoglobulin alpha Fc receptor
             HIF ID HIFM0097 HIF Info       Class Fc Receptor (FCR)
             Description Enhanced in vitro uptake of Porphyromonas gingivalis by neutrophils after targeting of FcRI(CD89) has been demonstrated. [15]
          Neutrophils
             HIF ID HIFC0029 HIF Info       Class Granulocytes (Gra)
             Description Neutrophils mounted the oxidative burst response is an efficient strategy for infection with Porphyromonas gingivalis. [16]
          Immunoglobulin M
             HIF ID HIFM0266 HIF Info       Class Immunoglobulin (Ig)
             Description The activity of proteolytic enzymes from Porphyromonas gingivalis could effect enzymolysis of human immunoglobulin M(lgM). [17]
          Immunoglobulin G3
             HIF ID HIFM0267 HIF Info       Class Immunoglobulin (Ig)
             Description The activity of proteolytic enzymes from Porphyromonas gingivalis could effect enzymolysis of human immunoglobulin G3(lgG3). [17]
          Immunoglobulin G2
             HIF ID HIFM0268 HIF Info       Class Immunoglobulin (Ig)
             Description The activity of proteolytic enzymes from Porphyromonas gingivalis could effect enzymolysis of human immunoglobulin G2(lgG2). [17]
          Immunoglobulin G1
             HIF ID HIFM0269 HIF Info       Class Immunoglobulin (Ig)
             Description The activity of proteolytic enzymes from Porphyromonas gingivalis could effect enzymolysis of human immunoglobulin G1(lgG1). [17]
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description The activity of proteolytic enzymes from Porphyromonas gingivalis could effect enzymolysis of human immunoglobulin G(lgG). [17]
          Immunoglobulin E
             HIF ID HIFM0271 HIF Info       Class Immunoglobulin (Ig)
             Description The activity of proteolytic enzymes from Porphyromonas gingivalis could effect enzymolysis of human immunoglobulin E(lgE). [17]
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description The activity of proteolytic enzymes from Porphyromonas gingivalis could effect enzymolysis of human immunoglobulin A(lgA). [17]
          Immunoglobulin A1
             HIF ID HIFM0275 HIF Info       Class Immunoglobulin (Ig)
             Description The activity of proteolytic enzymes from Porphyromonas gingivalis could effect enzymolysis of human immunoglobulin A1(lgA1). [17]
          Immunoglobulin A2
             HIF ID HIFM0276 HIF Info       Class Immunoglobulin (Ig)
             Description The activity of proteolytic enzymes from Porphyromonas gingivalis could effect enzymolysis of human immunoglobulin A2(lgA2). [17]
          Immunoglobulin D
             HIF ID HIFM0277 HIF Info       Class Immunoglobulin (Ig)
             Description Specific antibody to Porphyromonas gingivalis is lower in IgD deficient mice. [18]
          Immunoglobulin G4
             HIF ID HIFM0278 HIF Info       Class Immunoglobulin (Ig)
             Description The activity of proteolytic enzymes from Porphyromonas gingivalis could effect enzymolysis of human immunoglobulin G4(lgG4). [17]
          M1 macrophages
             HIF ID HIFC0019 HIF Info       Class Macrophages (Mac)
             Description Porphyromonas gingivalis induced predominantly pro-inflammatory (M1 macrophages-like phenotypes) responses. [19]
          Toll like receptor 2 signalling pathway
             HIF ID HIFP0044 HIF Info       Class Signaling pathway (SP)
             Description Porphyromonas gingivalis surface molecules has regulatory affinity which could bind to tolllike receptor 2 (TLR2) on platelets, further strengthening platelets as bacterial sensors in the circulation. [12]
          T helper type 17 cells
             HIF ID HIFC0080 HIF Info       Class T cells (TCs)
             Description Porphyromonas gingivalis promoted T helper type 17 (Th17) cells responses through the production of Th17-polarizing cytokines even in chronic periodontitis. [20]
          Toll-like receptor 1
             HIF ID HIFM0216 HIF Info       Class Toll-like receptor (TLR)
             Description TLR2/1 ligation induces cytokine and chemokine release which is antagonized by Porphyromonas gingivalis. [12]
          Toll-like receptor 2
             HIF ID HIFM0217 HIF Info       Class Toll-like receptor (TLR)
             Description TLR2/1 ligation induces cytokine and chemokine release which is antagonized by Porphyromonas gingivalis. [12]
Environmental Factor(s)
             Disbiome ID
      304
             gutMDisorder ID
      gm0533
             aBiofilm Organism
      Porphyromonas gingivalis
References
1 Association of Bacteroides forsythus and a novel Bacteroides phylotype with periodontitis. J Clin Microbiol. 2002 Mar;40(3):821-5. doi: 10.1128/jcm.40.3.821-825.2002.
2 Periodontal bacteria in the genital tract: are they related to adverse pregnancy outcome. Int J Immunopathol Pharmacol. 2013 Oct-Dec;26(4):931-9. doi: 10.1177/039463201302600411.
3 Cystic Fibrosis Plasma Blunts the Immune Response to Bacterial Infection. Zhang X, Pan A, Jia S, Ideozu JE, Woods K, Murkowski K, Hessner MJ, Simpson PM, Levy H.. Am J Respir Cell Mol Biol. 2019 Sep;61(3):301-311. doi: 10.1165/rcmb.2018-0114OC.
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