General Information of HGF (ID: HGF0243)
HGF Name hsa-miR-155-5p
HGF Synonym(s) microRNA 155-5p, MIRN155-5p, MIR155-5p
Source Homo sapiens
HGF Classification Non-coding RNA: Micro (ncRNA-miRNA)
Gene Location chr21
Gene Start Site 25573983 Gene End Site 25574006
Strand Forward (+)
Sequence Click here to download the HGF sequence in FASTA format
External Links
miRBase ID
MIMAT0000646
Microbe Species (MIC) Regulated by This HGF
         Aeromonas salmonicida (gamma-proteobacteria) MIC00048
             Description The over-and suppressed expression of miR-1555p significantly enhanced and reduced the IL-2 and IL-1 expressions in RTG-2 cells induced by Aeromonas salmonicida, respectively. [1]
         Bacteroides fragilis (CFB bacteria) MIC00158
             Description Bacteroides fragilis-associated lncRNA1 regulated RHEB expression by miR-155-5p. [2]
         Bifidobacterium bifidum (actinobacteria) MIC00209
             Description Bifidobacterium bifidum-associated lncRNA1 controlled RHEB expression by sponging hsa-miR-155-5p. [3]
         Candida albicans (budding yeasts) MIC00317
             Description The expression of miR-155-5p was significantly up-regulated, when macrophages were challenged with heat-killed Candida albicans (p-value<0.05). [4]
         Chlamydia trachomatis (chlamydias) MIC00344
             Description The expression of miR-155 was significantly up-regulated during Chlamydia trachomatis infection (p-value<0.05). [5]
         Citrobacter rodentium (enterobacteria) MIC00366
             Description The deficiency of miR-155-5p resulted in a longer bacterial clearance time and an impaired humoral immune response to Citrobacter rodentium infection at intestinal lumen level. [6]
         Corynebacteriales (actinobacteria) MIC00842
             Description The miR-155 promotes autophagy to eliminate intracellular mycobacteria by targeting Rheb. [7]
         Francisella sp. (gamma-proteobacteria) MIC00605
             Description The level of miR-155 expression was significantly upregulated by Francisella (p-value<0.05). [8]
         Helicobacter pylori (epsilon-proteobacteria) MIC00669
             Description The level of miR-155 up-regulating expression could relieve the Helicobacter pylori-induced gastric inflammatory reaction. [9]
         Lactobacillus acidophilus (firmicutes) MIC00702
             Description The level of miR-155 expression was 1.36-fold up-regulation in Lactobacillus acidophilus. [10]
         Listeria monocytogenes (firmicutes) MIC00771
             Description The miR-155-5p may mediate the proinflammatory responses of host immune responses to Listeria monocytogenes infection. [11]
         Mycobacterium tuberculosis (actinobacteria) MIC00857
             Description The level of miR-155 expression showed significantly downregulated in Mycobacterium tuberculosis infection (p-value<0.05). [12]
         Porphyromonas gingivalis (CFB bacteria) MIC01000
             Description The level of miR-155 expression is associated with the abundance of Porphyromonas gingivalis (p-value<0.05). [13]
         Pseudomonas aeruginosa (gamma-proteobacteria) MIC01054
             Description The negative feedback miRNAs, such as miR-155, whose levels are enhanced upon Pseudomonas aeruginosa infection to downregulate levels of immune response genes. [11]
         Salmonella enterica (enterobacteria) MIC01150
             Description The level of miR-155 expression and a specific host miRNA response with it takes place during infection with Salmonella enterica. [14]
         Salmonella enterica subsp. enterica (enterobacteria) MIC01154
             Description The level of miR-155 expression is essential in the vaccination process against Salmonella typhimurium. [12]
         Staphylococcus aureus (firmicutes) MIC01208
             Description The level of miR-155 expression showed significantly upregulated upon Staphylococcus aureus infection (p-value<0.05). [8]
         Tannerella forsythia (CFB bacteria) MIC01305
             Description The level of miR-155 expression failed to be increased by Tannerella forsythia. [13]
         Treponema denticola (spirochetes) MIC01322
             Description The level of miR-155 expression failed to be increased by Treponema denticola. [13]
References
1 A transcriptome analysis focusing on splenic immune-related mciroRNAs of rainbow trout upon Aeromonas salmonicida subsp. salmonicida infection. Fish Shellfish Immunol. 2019 Aug;91:350-357. doi: 10.1016/j.fsi.2019.05.048. Epub 2019 May 23.
2 Long noncoding RNA BFAL1 mediates enterotoxigenic Bacteroides fragilis-related carcinogenesis in colorectal cancer via the RHEB/mTOR pathway. Cell Death Dis. 2019 Sep 12;10(9):675. doi: 10.1038/s41419-019-1925-2.
3 Influence of Aspergillus fumigatus conidia viability on murine pulmonary microRNA and mRNA expression following subchronic inhalation exposure. Croston TL, Nayak AP, Lemons AR, Goldsmith WT, Gu JK, Germolec DR, Beezhold DH, Green BJ.. Clin Exp Allergy. 2016 Oct;46(10):1315-27. doi: 10.1111/cea.12783. Epub 2016 Sep 16.
4 Mixed-species biofilm compromises wound healing by disrupting epidermal barrier function. Roy S, Elgharably H, Sinha M, Ganesh K, Chaney S, Mann E, Miller C, Khanna S, Bergdall VK, Powell HM, Cook CH, Gordillo GM, Wozniak DJ, Sen CK.. J Pathol. 2014 Aug;233(4):331-343. doi: 10.1002/path.4360. Epub 2014 May 27.
5 miRNAs that associate with conjunctival inflammation and ocular Chlamydia trachomatis infection do not predict progressive disease. Pathog Dis. 2017 Mar 1;75(2):ftx016. doi: 10.1093/femspd/ftx016.
6 Enhanced susceptibility to Citrobacter rodentium infection in microRNA-155-deficient mice. Infect Immun. 2013 Mar;81(3):723-32. doi: 10.1128/IAI.00969-12. Epub 2012 Dec 21.
7 MicroRNA-155 promotes autophagy to eliminate intracellular mycobacteria by targeting Rheb. PLoS Pathog. 2013;9(10):e1003697. doi: 10.1371/journal.ppat.1003697. Epub 2013 Oct 10.
8 Multifaceted Roles of microRNAs in Host-Bacterial Pathogen Interaction. Microbiol Spectr. 2019 May;7(3). doi: 10.1128/microbiolspec.BAI-0002-2019.
9 A multi-epitope vaccine CTB-UE relieves Helicobacter pylori-induced gastric inflammatory reaction via up-regulating microRNA-155 to inhibit Th17 response in C57/BL6 mice model. Hum Vaccin Immunother. 2014;10(12):3561-9. doi: 10.4161/hv.36096.
10 Expression profiling of peripheral blood miRNA using RNAseq technology in dairy cows with Escherichia coli-induced mastitis. Luoreng ZM, Wang XP, Mei CG, Zan LS.. Sci Rep. 2018 Aug 23;8(1):12693. doi: 10.1038/s41598-018-30518-2.
11 miRNAs reshape immunity and inflammatory responses in bacterial infection. Signal Transduct Target Ther. 2018 May 25;3:14. doi: 10.1038/s41392-018-0006-9. eCollection 2018.
12 Mammalian microRNAs and long noncoding RNAs in the host-bacterial pathogen crosstalk. Semin Cell Dev Biol. 2017 May;65:11-19. doi: 10.1016/j.semcdb.2016.06.016. Epub 2016 Jul 2.
13 Polymicrobial infection alter inflammatory microRNA in rat salivary glands during periodontal disease. Anaerobe. 2016 Apr;38:70-75. doi: 10.1016/j.anaerobe.2015.10.005. Epub 2015 Oct 22.
14 The intestinal microbiota interferes with the microRNA response upon oral Listeria infection. mBio. 2013 Dec 10;4(6):e00707-13. doi: 10.1128/mBio.00707-13.

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