General Information of MIC (ID: MIC00842)
MIC Name	Corynebacteriales (actinobacteria)
MIC Synonyms	Corynebacterineae, Mycobacteriales
Body Site	Skin
Lineage	Kingdom: Bacteria Phylum: Actinobacteria Class: Actinobacteria Order: Corynebacteriales
Oxygen Sensitivity	Aerobe
Gram	Positive
Description	The Corynebacterineae comprise a suborder of the Actinomycetales and include most of the acid-fast bacteria. Therewith it is a subgroup of the high GC-content and Gram-positive bacteria. Among its subgroup Mycobacteriaceae are the species which cause tuberculosis and leprosy.
External Links	Taxonomy ID	85007

Host Genetic Factors (HGFs)
hsa-miR-155-5p
HGF ID	HGF0243	HGF Info	Class	Non-coding RNA: Micro (ncRNA-miRNA)
Description	The miR-155 promotes autophagy to eliminate intracellular mycobacteria by targeting Rheb.				[1]
rs5743618
HGF ID	HGF1290	HGF Info	Class	Single Nucleotide Polymorphism: Missense variant (SNP-MV)
Description	The rs5743618 was associated with the thatoptimal mycobacterial TLR2 signaling.				[2]

Host Immune Factors (HIFs)
Cathelicidin antimicrobial peptide
HIF ID	HIFM0014	HIF Info	Class	Antimicrobial peptide (AMP)
Description	The human cathelicidin hCAP18/LL-37: a multifunctional peptide involved in the abundance of mycobacterial infections.				[3]
Eosinophil cationic protein
HIF ID	HIFM0094	HIF Info	Class	Antimicrobial peptide (AMP)
Description	The RNase 3 were indeed able to totally inhibit mycobacterial growth in a low micromolar range, showing MIC100s from 10 to 20 M.				[4]
Secretory leukocyte protease inhibitor
HIF ID	HIFM0208	HIF Info	Class	Antimicrobial peptide (AMP)
Description	Secretory leukocyte protease inhibitoris (SLPI) has antiprotease activity and detrimental to mycobacteria.				[5]

References
1	MicroRNA-155 promotes autophagy to eliminate intracellular mycobacteria by targeting Rheb. PLoS Pathog. 2013;9(10):e1003697. doi: 10.1371/journal.ppat.1003697. Epub 2013 Oct 10.
2	Cystic fibrosis CFBE41o- cells contain TLR1 SNP I602S and fail to respond to Mycobacterium abscessus.J Cyst Fibros. 2013 Dec;12(6):773-9. doi: 10.1016/j.jcf.2013.01.001. Epub 2013 Feb 9.
3	The human cathelicidin hCAP18/LL-37: a multifunctional peptide involved in mycobacterial infections.Peptides. 2010 Sep;31(9):1791-8. doi: 10.1016/j.peptides.2010.06.016. Epub 2010 Jun 25.
4	Exploring the mechanisms of action of human secretory RNase 3 and RNase 7 against Candida albicans.Microbiologyopen. 2016 Oct;5(5):830-845. doi: 10.1002/mbo3.373. Epub 2016 Jun 8.
5	Not Avaliable

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