Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0208)
HIF Name
Secretory leukocyte protease inhibitor
HIF Synonym(s)
SLPI, antileukoprotease, ALP, BLPI, HUSI-1, MPI
HIF Classification
Antimicrobial peptide (AMP)
Molecular Function
Antibiotic; Antimicrobial; Protease inhibitor; Serine protease inhibitor
Description SLPI has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system. [1]
Pfam WAP-type (Whey Acidic Protein) 'four-disulfide core' (PF00095 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
SLPI_HUMAN
APD ID
AP02099
Microbe Species (MIC) Regulated by This HIF
         Corynebacteriales (actinobacteria) MIC00842
             Description Secretory leukocyte protease inhibitoris (SLPI) has antiprotease activity and detrimental to mycobacteria. [2]
         Escherichia coli (enterobacteria) MIC00516
             Description Secretory leukocyte protease inhibitoris (SLPI) has antiprotease activity and is detrimental to Escherichia coli. [2]
         Gardnerella vaginalis (actinobacteria) MIC00626
             Description A strong positively correlation was observed between Gardnerella vaginalis with SLPI. [3]
         Lactobacillus iners (firmicutes) MIC00719
             Description A strong positively correlation was observed between Lactobacillus iners and SLPI. [3]
References
1 APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2 Not Avaliable
3 The lower genital tract microbiota in relation to cytokine-, SLPI- and endotoxin levels: application of checkerboard DNA-DNA hybridization (CDH). APMIS. 2008 Apr;116(4):263-77. doi: 10.1111/j.1600-0463.2008.00808.x.

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