Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00626)
MIC Name Gardnerella vaginalis (actinobacteria)
MIC Synonyms Haemophilus hemolyticus vaginalis
Body Site Vagina
Lineage Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Bifidobacteriales
Family: Bifidobacteriaceae
Genus: Gardnerella
Species: Gardnerella vaginalis
Gram Variable
Description Gardnerella vaginalis is a species of Gardnerella genus, which is a Gram-variable-staining facultative anaerobic bacterium.
External Links Taxonomy ID
2702
Genome Assembly ID
ASM104978v1
GOLD Organism ID
Go0004673
Disease Relevance
          Vaginitis  [ICD-11: GA02]
             Description Gardnerella vaginitis was associated with bacterial vaginosis. [1]
Host Genetic Factors (HGFs)
          hsa-let-7f-5p
             HGF ID HGF0297 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-15a expression was significantly upregulated by Gardnella vaginalis infection (p-value<0.05). [2]
          hsa-miR-143-3p
             HGF ID HGF0258 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-143 expression was significantly upregulated by Gardnella vaginalis infection (p-value<0.05). [2]
          hsa-miR-145-5p
             HGF ID HGF0254 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-145 expression was significantly upregulated by Gardnella vaginalis infection (p-value<0.05). [2]
          hsa-miR-146a-5p
             HGF ID HGF0252 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-146 expression was significantly upregulated by Gardnella vaginalis infection (p-value<0.05). [2]
          hsa-miR-148a-3p
             HGF ID HGF0249 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-148 expression was significantly upregulated by Gardnella vaginalis infection (p-value<0.05). [2]
          hsa-miR-223-3p
             HGF ID HGF0194 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-223 expression was significantly upregulated by Gardnella vaginalis infection (p-value<0.05). [2]
          rs4986790
             HGF ID HGF1279 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The varian TLR4 rs4986790 was associated with an increase in Gardnerella vaginalis. [3]
Host Immune Factors (HIFs)
          Secretory leukocyte protease inhibitor
             HIF ID HIFM0208 HIF Info       Class Antimicrobial peptide (AMP)
             Description A strong positively correlation was observed between Gardnerella vaginalis with SLPI. [4]
          Interferon-13
             HIF ID HIFM0132 HIF Info       Class Cytokine (Cyt)
             Description IL13 exhibited a correlation with the altered vaginal milieu microbe Gardnerella vaginalis(p=0.184). [5]
          Interleukin-1 beta
             HIF ID HIFM0138 HIF Info       Class Cytokine (Cyt)
             Description Gardnerella vaginalis colonization could cause 10-fold higher quantities with carrying a TLR4 polymorphism associated with lower response to LPS had no change in IL1 when colonized with BV-associated bacterial species. [6]
          Interferon-5
             HIF ID HIFM0150 HIF Info       Class Cytokine (Cyt)
             Description IL5 expression was significantly associated with the perturbation of the commensals Gardnerella vaginalis. [5]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Gardnerella vaginalis induce significantly higher levels of IL-6 than Lactobacillus species. [6]
          CD45+CD3-CD56+CD16+ Natural Killer cells
             HIF ID HIFC0180 HIF Info       Class Natural killer cells (NKCs)
             Description CD45+CD3-CD56+CD16+ pNK response had a statistically significant association with Gardnerella vaginalis in RM patients. [7]
          T helper type 2 cells
             HIF ID HIFC0085 HIF Info       Class T cells (TCs)
             Description Th2 cells secreted IL5 and IL13 which were significantly associated with the perturbation of Gardnerella vaginalis. [5]
Environmental Factor(s)
             Disbiome ID
      456
             aBiofilm Organism
      Gardnerella vaginalis
References
1 Mollicutes in vaginal microbiology: Mycoplasma hominis, Ureaplasma urealyticum, Ureaplasma parvum and Mycoplasma genitalium. Res Microbiol. 2017 Nov-Dec;168(9-10):875-881. doi: 10.1016/j.resmic.2017.02.009. Epub 2017 Mar 2.
2 Influence of Aspergillus fumigatus conidia viability on murine pulmonary microRNA and mRNA expression following subchronic inhalation exposure. Croston TL, Nayak AP, Lemons AR, Goldsmith WT, Gu JK, Germolec DR, Beezhold DH, Green BJ.. Clin Exp Allergy. 2016 Oct;46(10):1315-27. doi: 10.1111/cea.12783. Epub 2016 Sep 16.
3 Genetic association of Toll-like receptor 4 with cervical cytokine concentrations during pregnancy.Genes Immun. 2009 Oct;10(7):636-40. doi: 10.1038/gene.2009.47. Epub 2009 Jun 25.
4 The lower genital tract microbiota in relation to cytokine-, SLPI- and endotoxin levels: application of checkerboard DNA-DNA hybridization (CDH). APMIS. 2008 Apr;116(4):263-77. doi: 10.1111/j.1600-0463.2008.00808.x.
5 In vivo microbiome and associated immune markers: New insights into the pathogenesis of vaginal dysbiosis. Sci Rep. 2018 Feb 2;8(1):2307. doi: 10.1038/s41598-018-20649-x.
6 Bacterial vaginosis and the cervicovaginal immune response. Am J Reprod Immunol. 2014 Jun;71(6):555-63. doi: 10.1111/aji.12264.
7 Higher prevalence of colonization with Gardnerella vaginalis and gram-negative anaerobes in patients with recurrent miscarriage and elevated peripheral natural killer cells.J Reprod Immunol. 2017 Apr;120:15-19. doi: 10.1016/j.jri.2017.03.001. Epub 2017 Mar 30.

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