General Information of HIF (ID: HIFM0150)
HIF Name	Interferon-5
HIF Synonym(s)	interleukin 5, IL5, EDF, TRF
HIF Classification	Cytokine (Cyt)
Molecular Function	Cytokine; Growth factor
Description	Interleukin-5 (IL-5) is an interdigitating, homodimeric glycoprotein with a molecular mass of 4060 kDa that is identified by its ability to support the growth and differentiation of B cells and eosinophils.				[1]
Pfam	Interleukin 5 (PF02025 )
Pathway	Allograft rejection (hsa05330 )
	Asthma (hsa05310 )
	Autoimmune thyroid disease (hsa05320 )
	Cytokine-cytokine receptor interaction (hsa04060 )
	Fc epsilon RI signaling pathway (hsa04664 )
	Hematopoietic cell lineage (hsa04640 )
	IL-17 signaling pathway (hsa04657 )
	Inflammatory bowel disease (IBD) (hsa05321 )
	Intestinal immune network for IgA production (hsa04672 )
	JAK-STAT signaling pathway (hsa04630 )
	Pathways in cancer (hsa05200 )
	T cell receptor signaling pathway (hsa04660 )
	Th1 and Th2 cell differentiation (hsa04658 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	IL5_HUMAN

Microbe Species (MIC) Regulated by This HIF
Clostridium leptum (firmicutes)			MIC00402
Description	Early-life Clostridium leptum exposure induced an immunosuppressive environment in the lung concurrent with increased Treg cells, resulting in the inhibition of Th2 cell responses,which secreted IL-5.				[2]
Enterococcus faecalis (firmicutes)			MIC00548
Description	IL-5 level was significantly lower when Enterococcus faecalis wound titers resolved to 105 CFU.				[3]
Escherichia coli (enterobacteria)			MIC00516
Description	Escherichia coli increased significantly the mRNA expression (p-value<0.01) of thehe pro-Th2 cytokine IL-5 (2.56 fold change) in IPEC-1 cells.				[4]
Gardnerella vaginalis (actinobacteria)			MIC00626
Description	IL5 expression was significantly associated with the perturbation of the commensals Gardnerella vaginalis.				[5]
Granulicatella adiacens (firmicutes)			MIC00645
Description	Granulicatella is positive correlation with IL-5 expression.				[6]
Trichophyton tonsurans (ascomycetes)			MIC01333
Description	Trichophyton tonsurans is associated with IL-5 expression.				[7]

References
1	IL-5 and eosinophilia.Curr Opin Immunol. 2008 Jun;20(3):288-94. doi: 10.1016/j.coi.2008.04.001. Epub 2008 May 27.
2	Early-Life Exposure to Clostridium leptum Causes Pulmonary Immunosuppression. PLoS One. 2015 Nov 13;10(11):e0141717. doi: 10.1371/journal.pone.0141717. eCollection 2015.
3	Enterococcus faecalis Modulates Immune Activation and Slows Healing During Wound Infection. J Infect Dis. 2017 Dec 19;216(12):1644-1654. doi: 10.1093/infdis/jix541.
4	Saccharomyces cerevisiae modulates immune gene expressions and inhibits ETEC-mediated ERK1/2 and p38 signaling pathways in intestinal epithelial cells. PLoS One. 2011 Apr 4;6(4):e18573. doi: 10.1371/journal.pone.0018573.
5	In vivo microbiome and associated immune markers: New insights into the pathogenesis of vaginal dysbiosis. Sci Rep. 2018 Feb 2;8(1):2307. doi: 10.1038/s41598-018-20649-x.
6	The imbalance of gut microbiota and its correlation with plasma inflammatory cytokines in pemphigus vulgaris patients. Scand J Immunol. 2019 Sep;90(3):e12799. doi: 10.1111/sji.12799. Epub 2019 Jul 8.
7	The immune response to Trichophyton tonsurans: distinct T cell cytokine profiles to a single protein among subjects with immediate and delayed hypersensitivity. J Immunol. 1996 Dec 1;157(11):5192-7.

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