Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00645)
MIC Name Granulicatella adiacens (firmicutes)
MIC Synonyms Abiotrophia adiacens
Body Site Oral Cavity
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Carnobacteriaceae
Genus: Granulicatella
Species: Granulicatella adiacens
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Positive
Host Relationship Commensal
Genome Size (bp) 1923088
Description Granulicatella adiacens is a species of facultatively anaerobic, Gram positive, with streptococcus morphology. It is a normal commensal of human mucosal surfaces, inhabiting the oral cavity, urogenital and gastrointestinal tracts and rarely causing disease. G. adiacens has been associated with bacteremia and endovascular, central nervous system, ocular, oral, bone and joint and genitourinary infections.
External Links Taxonomy ID
46124
Genome Assembly ID
ASM16067v1
GOLD Organism ID
Go0001275
Disease Relevance
          Chronic obstructive pulmonary disease  [ICD-11: CA22]
             Description Granulicatella was associated with chronic obstructive pulmonary disease. [1]
          Meningococcal disease  [ICD-11: 1C1C]
             Description Granulicatella adiacens has been an important cause of bacteremia associated with significant morbidity and mortality. [2]
          Periodontal disease  [ICD-11: DA0C]
             Description Granulicatella adiacens can take part in the microbiota associated with primary endodontic infection. [3]
Host Genetic Factors (HGFs)
          rs7167023
             HGF ID HGF1858 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs7167023 SNP was significantly associated with the abundance of Granulicatella adiacens (p-value<1.00E-08). [4]
          rs3830130
             HGF ID HGF1739 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs3830130 SNP is significantly associated with the abundance of Granulicatella (p-value=3.83E-04). [5]
          rs3734264
             HGF ID HGF1246 HGF Info       Class Single Nucleotide Polymorphism: Synonymous variant (SNP-SV)
             Description The rs3734264 SNP was significantly associated with the abundance of Granulicatella (p-value=7.71E-07). [6]
Host Immune Factors (HIFs)
          Interleukin-17A
             HIF ID HIFM0134 HIF Info       Class Cytokine (Cyt)
             Description Granulicatella is positive correlation with IL-17A expression. [7]
          Interleukin-1 beta
             HIF ID HIFM0138 HIF Info       Class Cytokine (Cyt)
             Description Granulicatella is positive correlation with IL-1beta expression. [7]
          Interferon-21
             HIF ID HIFM0142 HIF Info       Class Cytokine (Cyt)
             Description Granulicatella is positive correlation with IL-21 expression. [7]
          Interleukin-2 receptor
             HIF ID HIFM0147 HIF Info       Class Cytokine (Cyt)
             Description Granulicatella is positive correlation with IL-2R expression. [7]
          Interferon-5
             HIF ID HIFM0150 HIF Info       Class Cytokine (Cyt)
             Description Granulicatella is positive correlation with IL-5 expression. [7]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Granulicatella is positive correlation with IL-6 expression. [7]
          Interferon-7
             HIF ID HIFM0152 HIF Info       Class Cytokine (Cyt)
             Description Granulicatella is positive correlation with IL-7 expression. [7]
          C-X-C motif chemokine 8
             HIF ID HIFM0153 HIF Info       Class Cytokine (Cyt)
             Description Granulicatella is positive correlation with IL-8 expression. [7]
          Neutrophils
             HIF ID HIFC0029 HIF Info       Class Granulocytes (Gra)
             Description The percentage of sputum neutrophils was negatively correlated with the levels of Granulicatella adiacens. [8]
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description IgG immune responses is associated with Granulicatella. [7]
Environmental Factor(s)
             Disbiome ID
      430
             gutMDisorder ID
      gm0356
References
1 [Comparison Study of Oropharyngeal Microbiota in Case of Bronchial Asthma and Chronic Obstructive Pulmonary Disease in Different Severity Levels]. Vestn Ross Akad Med Nauk. 2015;(6):669-78. doi: 10.15690/vramn532.
2 Antimicrobial Susceptibilities of Abiotrophia defectiva, Granulicatella adiacens, and Granulicatella elegans. Antimicrob Agents Chemother. 2015 Dec 14;60(3):1411-20. doi: 10.1128/AAC.02645-15.
3 Catonella morbi and Granulicatella adiacens: new species in endodontic infections. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Aug;102(2):259-64. doi: 10.1016/j.tripleo.2005.09.021. Epub 2006 Apr 21.
4 Host genetic variation and its microbiome interactions within the Human Microbiome Project.Genome Med. 2018 Jan 29;10(1):6. doi: 10.1186/s13073-018-0515-8.
5 Whole exome sequencing analyses reveal gene-microbiota interactions in the context of IBD.Gut. 2020 Jul 10:gutjnl-2019-319706. doi: 10.1136/gutjnl-2019-319706. Online ahead of print.
6 Host genetic variation impacts microbiome composition across human body sites.Genome Biol. 2015 Sep 15;16(1):191. doi: 10.1186/s13059-015-0759-1.
7 The imbalance of gut microbiota and its correlation with plasma inflammatory cytokines in pemphigus vulgaris patients. Scand J Immunol. 2019 Sep;90(3):e12799. doi: 10.1111/sji.12799. Epub 2019 Jul 8.
8 Relationship of Microbial Profile With Airway Immune Response in Eosinophilic or Neutrophilic Inflammation of Asthmatics. Allergy Asthma Immunol Res. 2020 May;12(3):412-429. doi: 10.4168/aair.2020.12.3.412.

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