General Information of HIF (ID: HIFC0029)
HIF Name	Neutrophils
HIF Synonym(s)	Neutrophils
HIF Classification	Granulocytes (Gra)
Description	Neutrophil, type of white blood cell (leukocyte) that is characterized histologically by its ability to be stained by neutral dyes and functionally by its role in mediating immune responses against infectious microorganisms.				[1]

Microbe Species (MIC) Regulated by This HIF
Acinetobacter baumannii (gamma-proteobacteria)			MIC00016
Description	Caspase-11 deficiency aggravated the pulmonary inflammatory response to Acinetobacter baumannii infection, which was characterized by extensive neutrophil infiltration and consolidation.				[2]
Actinobacillus pleuropneumoniae (gamma-proteobacteria)			MIC00026
Description	Actinobacillus pleuropneumoniae was eliminated from inflamed lung tissue, which was characterized by an influx of neutrophils.				[3]
Actinobacteria (actinobacteria)			MIC00025
Description	Actinobacteria was positively correlated with subsequent GVHD(Graft-versus-host disease) neutrophil recovery post-HCTpost-hematopoietic cell transplantation).				[4]
Aggregatibacter actinomycetemcomitans (gamma-proteobacteria)			MIC00051
Description	Aggregatibacter actinomycetemcomitans induced Hypercitrullination in human neutrophils.				[5]
Bacteroides caccae (CFB bacteria)			MIC00148
Description	Bacteroides caccae at neutrophil recovery was negatively correlated with subsequent acute severe graft-versus-host disease.				[4]
Bacteroides dorei (CFB bacteria)			MIC00154
Description	Bacteroides dorei at neutrophil recovery was positively correlated with subsequent acute severe graft-versus-host disease.				[4]
Bacteroides ovatus (CFB bacteria)			MIC00167
Description	Bacteroides ovatus at neutrophil recovery was negatively correlated with subsequent acute severe graft-versus-host disease.				[4]
Bacteroides thetaiotaomicron (CFB bacteria)			MIC00179
Description	Bacteroides thetaiotaomicron at neutrophil recovery was negatively correlated with subsequent acute severe graft-versus-host disease.				[4]
Blautia luti (firmicutes)			MIC01989
Description	Blautia luti at neutrophil recovery was negatively correlated with subsequent acute severe graft-versus-host disease.				[4]
Blautia producta (firmicutes)			MIC00981
Description	Blautia spp. at neutrophil recovery was negatively correlated with subsequent acute severe graft-versus-host disease.				[4]
Butyricicoccus pullicaecorum (firmicutes)			MIC00293
Description	Butyricicoccus spp. at neutrophil recovery was negatively correlated with subsequent acute severe graft-versus-host disease.				[4]
Candidatus Soleaferrea (firmicutes)			MIC01990
Description	Candidatus soleaferrea at neutrophil recovery was negatively correlated with subsequent acute severe graft-versus-host disease.				[4]
Clostridioides difficile (firmicutes)			MIC00396
Description	Neutrophils increased the immune response to Clostridium difficile toxin A.				[6]
Dorea sp. (firmicutes)			MIC00513
Description	Dorea spp. at neutrophil recovery was negatively correlated with subsequent acute severe graft-versus-host disease.				[4]
Ehrlichia chaffeensis (alpha-proteobacteria)			MIC00523
Description	Ehrlichia chaffeensis lipoproteins may be able to activate TLR2-expressing neutrophils.				[7]
Eisenbergiella (firmicutes)			MIC01991
Description	Eisenbergiella spp. at neutrophil recovery was positively correlated with subsequent acute severe graft-versus-host disease.				[4]
Enterocloster clostridioformis (firmicutes)			MIC00391
Description	Clostridium clostridioforme at neutrophil recovery was negatively correlated with subsequent acute severe graft-versus-host disease.				[4]
Erysipelatoclostridium ramosum (firmicutes)			MIC00414
Description	Erysipelatoclostridium ramosum at neutrophil recovery was negatively correlated with subsequent acute severe graft-versus-host disease.				[4]
Escherichia coli (enterobacteria)			MIC00516
Description	The bacterium Escherichia coli could cross-react with melanocyte-stimulating hormone (alpha-MSH).				[8]
Eubacterium saphenum (firmicutes)			MIC00579
Description	Neutrophils appeared first in peritoneal exudates after the injection of Eubacterium saphenum.				[9]
Filifactor alocis (firmicutes)			MIC00595
Description	Massive neutrophil infiltration was observed in the spleen and lungs infected by Filifactor alocis, and the recruited neutrophils were in close proximity to the infecting bacteria.				[10]
Fusobacterium nucleatum (fusobacteria)			MIC00617
Description	Patent neutrophils present a primed phenotype when challenged ex vivo with Fusobacterium nucleatum.				[11]
Granulicatella adiacens (firmicutes)			MIC00645
Description	The percentage of sputum neutrophils was negatively correlated with the levels of Granulicatella adiacens.				[12]
Klebsiella pneumoniae (enterobacteria)			MIC01405
Description	Neutrophils are critical to the host in clearance of ST258 Klebsiella pneumoniae.				[13]
Lactobacillus farciminis (firmicutes)			MIC00713
Description	Lactobacillus farciminis was associated with neutrophils responses.				[14]
Lactobacillus fermentum (firmicutes)			MIC00714
Description	Lactobacillus fermentum at neutrophil recovery was positively correlated with subsequent acute severe graft-versus-host disease.				[4]
Lactobacillus salivarius (firmicutes)			MIC00735
Description	Lactobacillus salivarius at neutrophil recovery was positively correlated with subsequent acute severe graft-versus-host disease.				[4]
Listeria monocytogenes (firmicutes)			MIC00771
Description	Listeria monocytogenes is associated with Neutrophils responses.				[15]
Mycobacterium tuberculosis (actinobacteria)			MIC00857
Description	Mycobacterium tuberculosis interfered with the functions of neutrophils.				[16]
Mycobacteroides abscessus (actinobacteria)			MIC00845
Description	Neutrophils were important components in the host defense against Mycobacterium abscessus infection.				[17]
Neisseria sp. (beta-proteobacteria)			MIC00900
Description	The Tfp of pathogenic Neisseria have been shown to mediate adhesion to the uropod of polarized neutrophils.				[18]
Porphyromonas gingivalis (CFB bacteria)			MIC01000
Description	Neutrophils mounted the oxidative burst response is an efficient strategy for infection with Porphyromonas gingivalis.				[11]
Pseudomonas aeruginosa (gamma-proteobacteria)			MIC01054
Description	Neutrophils has killed or inactivated activity against Pseudomonas aeruginosa.				[19]
Roseburia hominis (firmicutes)			MIC01117
Description	Roseburia hominis at neutrophil recovery was positively correlated with subsequent acute severe graft-versus-host disease.				[4]
Rothia mucilaginosa (actinobacteria)			MIC01125
Description	Rothia mucilaginosa at neutrophil recovery was positively correlated with subsequent acute severe graft-versus-host disease.				[4]
Ruminococcus sp. (firmicutes)			MIC01140
Description	Ruminococcus spp. at neutrophil recovery was negatively correlated with subsequent acute severe graft-versus-host disease.				[4]
Serratia marcescens (enterobacteria)			MIC01171
Description	Neutrophils were recruited rapidly to the corneal stroma following Serratia marcescens infection, and S. marcescens was killed rapidly in the cornea following neutrophil infiltration.				[20]
Solobacterium moorei (firmicutes)			MIC01192
Description	Solobacterium moorei at neutrophil recovery was positively correlated with subsequent acute severe graft-versus-host disease.				[4]
Streptococcus suis (firmicutes)			MIC01270
Description	Streptococcus suis can prevent neutrophil extracellular trap (NET) formation to avoid being trapped by neutrophils.				[21]
Treponema denticola (spirochetes)			MIC01322
Description	IL-8 neutrophils was recruited to the periodontal pockets, failed secreted when response to Treponema denticola exposure.				[11]
Veillonella parvula (firmicutes)			MIC01365
Description	Veillonella parvula at neutrophil recovery was positively correlated with subsequent acute severe graft-versus-host disease.				[4]
Yersinia pestis (enterobacteria)			MIC01401
Description	Neutrophil was the first defense against Yersinia pestis invading through phagocytosis and killing.				[22]

References
1	Biological Roles of Neutrophil-Derived Granule Proteins and Cytokines.Trends Immunol. 2019 Jul;40(7):648-664. doi: 10.1016/j.it.2019.05.003. Epub 2019 May 30.
2	Caspase-11 Plays a Protective Role in Pulmonary Acinetobacter baumannii Infection. Infect Immun. 2017 Sep 20;85(10):e00350-17. doi: 10.1128/IAI.00350-17. Print 2017 Oct.
3	Actinobacillus pleuropneumoniae triggers IL-10 expression in tonsils to mediate colonisation and persistence of infection in pigs. Vet Immunol Immunopathol. 2018 Nov;205:17-23. doi: 10.1016/j.vetimm.2018.10.008. Epub 2018 Oct 22.
4	Stool Microbiota at Neutrophil Recovery Is Predictive for Severe Acute Graft vs Host Disease After Hematopoietic Cell Transplantation.Clin Infect Dis. 2017 Nov 29;65(12):1984-1991. doi: 10.1093/cid/cix699.
5	Talk to your gut: the oral-gut microbiome axis and its immunomodulatory role in the etiology of rheumatoid arthritis.FEMS Microbiol Rev. 2019 Jan 1;43(1):1-18. doi: 10.1093/femsre/fuy035.
6	Immune responses to Clostridium difficile infection.Trends Mol Med. 2012 Nov;18(11):658-66. doi: 10.1016/j.molmed.2012.09.005. Epub 2012 Oct 16.
7	Proteomic analysis of and immune responses to Ehrlichia chaffeensis lipoproteins. Infect Immun. 2008 Aug;76(8):3405-14. doi: 10.1128/IAI.00056-08. Epub 2008 May 19.
8	Interactions between the microbiota, immune and nervous systems in health and disease. Nat Neurosci. 2017 Feb;20(2):145-155. doi: 10.1038/nn.4476. Epub 2017 Jan 16.
9	Intraperitoneal immune cell responses to Eubacterium saphenum in mice. Microbiol Immunol. 2001;45(1):29-37. doi: 10.1111/j.1348-0421.2001.tb01271.x.
10	Filifactor alocis infection and inflammatory responses in the mouse subcutaneous chamber model. Infect Immun. 2014 Mar;82(3):1205-12. doi: 10.1128/IAI.01434-13. Epub 2013 Dec 30.
11	Human neutrophils and oral microbiota: a constant tug-of-war between a harmonious and a discordant coexistence.Immunol Rev. 2016 Sep;273(1):282-98. doi: 10.1111/imr.12451.
12	Relationship of Microbial Profile With Airway Immune Response in Eosinophilic or Neutrophilic Inflammation of Asthmatics. Allergy Asthma Immunol Res. 2020 May;12(3):412-429. doi: 10.4168/aair.2020.12.3.412.
13	Pseudomonas aeruginosa and Klebsiella pneumoniae Adaptation to Innate Immune Clearance Mechanisms in the Lung. J Innate Immun. 2018;10(5-6):442-454. doi: 10.1159/000487515. Epub 2018 Apr 4.
14	Zymomonas mobilis culture protects against sepsis by modulating the inflammatory response, alleviating bacterial burden and suppressing splenocyte apoptosis. Eur J Pharm Sci. 2013 Jan 23;48(1-2):1-8. doi: 10.1016/j.ejps.2012.10.011. Epub 2012 Nov 2.
15	HDAC6 controls innate immune and autophagy responses to TLR-mediated signalling by the intracellular bacteria Listeria monocytogenes. PLoS Pathog. 2017 Dec 27;13(12):e1006799. doi: 10.1371/journal.ppat.1006799. eCollection 2017 Dec.
16	Immune Response to Mycobacterium tuberculosis: A Narrative Review. Front Pediatr. 2019 Aug 27;7:350. doi: 10.3389/fped.2019.00350. eCollection 2019.
17	Host immune response to rapidly growing mycobacteria, an emerging cause of chronic lung disease. Am J Respir Cell Mol Biol. 2010 Oct;43(4):387-93. doi: 10.1165/rcmb.2009-0276TR. Epub 2010 Jan 15.
18	The biology of Neisseria adhesins. Biology (Basel). 2013 Jul 29;2(3):1054-109. doi: 10.3390/biology2031054.
19	Intestinal Serum amyloid A suppresses systemic neutrophil activation and bactericidal activity in response to microbiota colonization.PLoS Pathog. 2019 Mar 7;15(3):e1007381. doi: 10.1371/journal.ppat.1007381. eCollection 2019 Mar.
20	Innate immune regulation of Serratia marcescens-induced corneal inflammation and infection. Invest Ophthalmol Vis Sci. 2012 Oct 25;53(11):7382-8. doi: 10.1167/iovs.12-10238.
21	How Streptococcus suis serotype 2 attempts to avoid attack by host immune defenses. J Microbiol Immunol Infect. 2019 Aug;52(4):516-525. doi: 10.1016/j.jmii.2019.03.003. Epub 2019 Mar 27.
22	Immunology of Yersinia pestis Infection. Adv Exp Med Biol. 2016;918:273-292. doi: 10.1007/978-94-024-0890-4_10.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.