Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00167)
MIC Name Bacteroides ovatus (CFB bacteria)
MIC Synonyms Pasteurella ovata
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
Species: Bacteroides ovatus
Oxygen Sensitivity Anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Negative
Host Relationship Commensal
Genome Size (bp) 6290059
No. of Coding Genes 5216
No. of Non-Coding Genes 62
No. of Small Non-Coding Genes 62
No. of Gene Transcripts 5278
No. of Base Pairs 6290059
Description Bacteroides ovatus is an obligate anaerobic, Gram negative common human gut bacterium. It is part of the normal human gut flora, however it is the least common of the Bacteroides intestinal isolates. It has also been associated with Coeliac disease.
External Links Taxonomy ID
28116
Genome Assembly ID
ASM157857v1
GOLD Organism ID
Go0000892
Disease Relevance
          Coeliac disease  [ICD-11: DA95]
             Description Bacteroides ovatus ATCC 8483 was associated with celiac disease. [1]
          Crohn disease  [ICD-11: DD70]
             Description Bacteroides ovatus ATCC 8483 was associated with Crohns disease. [1]
Host Genetic Factors (HGFs)
          AMY1A
             HGF ID HGF2311 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description The higher AMY1-CN has been associated with the abundance of Bacteroides ovatus. [2]
          SLC15A1
             HGF ID HGF2354 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of PepT1 could decrease the abundance of Bacteroides ovatus. [3]
          rs12455166
             HGF ID HGF2155 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs12455166 SNP was significantly associated with the abundance of Bacteroides ovatus (p-value<1.00E-08). [4]
          rs12401754
             HGF ID HGF1300 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs12401754 SNP was significantly associated with the abundance of Bacteroides ovatus (p-value<1.00E-08). [4]
          rs6920220
             HGF ID HGF2532 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs6920220 SNP is associated with the abundance of Bacteroides ovatus. [5]
          rs13407913
             HGF ID HGF2607 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs13407913 SNP is associated with the abundance of Bacteroides ovatus. [5]
          rs10486483
             HGF ID HGF2543 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs10486483 SNP is associated with the abundance of Bacteroides ovatus. [5]
          rs1440088
             HGF ID HGF2608 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1440088 SNP is associated with the abundance of Bacteroides ovatus. [5]
          rs1182188
             HGF ID HGF2600 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1182188 SNP is associated with the abundance of Bacteroides ovatus. [5]
          rs566416
             HGF ID HGF2551 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs566416 SNP is associated with the abundance of Bacteroides ovatus. [5]
          rs921720
             HGF ID HGF2528 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-UV)
             Description The rs921720 SNP is associated with the abundance of Bacteroides ovatus. [5]
Host Immune Factors (HIFs)
          Neutrophils
             HIF ID HIFC0029 HIF Info       Class Granulocytes (Gra)
             Description Bacteroides ovatus at neutrophil recovery was negatively correlated with subsequent acute severe graft-versus-host disease. [6]
          Immunoglobulin M
             HIF ID HIFM0266 HIF Info       Class Immunoglobulin (Ig)
             Description Bacteroides ovatus D-6 in the absence of adjuvants could develope specific anti-TFAlpha IgM and IgG antibodies. [7]
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description Mice immunized with Bacteroides ovatus D-6 in the absence of adjuvants developed specific anti-TFa IgM and IgG antibodies which also bound to human cancer cells carrying TFa. [7]
Environmental Factor(s)
             Disbiome ID
      279
             gutMDisorder ID
      gm0084
References
1 Comparative genomics of transport proteins in seven Bacteroides species. PLoS One. 2018 Dec 5;13(12):e0208151. doi: 10.1371/journal.pone.0208151. eCollection 2018.
2 Pretreatment Prevotella-to-Bacteroides ratio and salivary amylase gene copy number as prognostic markers for dietary weight loss.Am J Clin Nutr. 2020 May 1;111(5):1079-1086. doi: 10.1093/ajcn/nqaa007.
3 Impact of PepT1 deletion on microbiota composition and colitis requires multiple generations.NPJ Biofilms Microbiomes. 2020 Jul 21;6(1):27. doi: 10.1038/s41522-020-0137-y.
4 Host genetic variation and its microbiome interactions within the Human Microbiome Project.Genome Med. 2018 Jan 29;10(1):6. doi: 10.1186/s13073-018-0515-8.
5 A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice. Genetics. 2020 Mar;214(3):719-733. doi: 10.1534/genetics.119.303013. Epub 2020 Jan 2.
6 Stool Microbiota at Neutrophil Recovery Is Predictive for Severe Acute Graft vs Host Disease After Hematopoietic Cell Transplantation.Clin Infect Dis. 2017 Nov 29;65(12):1984-1991. doi: 10.1093/cid/cix699.
7 Specific humoral immune response to the Thomsen-Friedenreich tumor antigen (CD176) in mice after vaccination with the commensal bacterium Bacteroides ovatus D-6. Cancer Immunol Immunother. 2013 May;62(5):875-87. doi: 10.1007/s00262-013-1394-x. Epub 2013 Feb 5.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.