General Information of HIF (ID: HIFM0270)
HIF Name	Immunoglobulin G
HIF Synonym(s)	IgG
HIF Classification	Immunoglobulin (Ig)
Description	Immunoglobulin G(IgG) is the most common isotype of Immunoglobulin and include four subclasses which differ from one another in the following ways: their initial amino acid sequence, their physical and chemical properties and the different serum concentrations reached with age.				[1]

Microbe Species (MIC) Regulated by This HIF
Achromobacter xylosoxidans (beta-proteobacteria)			MIC00007
Description	Achromobacter could be preferentially enriched in the IgG-targeted fraction of the microbiota.				[2]
Actinobacillus equuli (gamma-proteobacteria)			MIC01766
Description	Opsonisation by specific IgG was necessary for efficient phagocytosis of Actinobacillus equuli by alveolar macrophages.				[3]
Actinomyces naeslundii (actinobacteria)			MIC00033
Description	IgG immune responses is associated with Actinomyces naeslundii.				[4]
Aggregatibacter actinomycetemcomitans (gamma-proteobacteria)			MIC00051
Description	IgG immune responses is associated with the Actinobacillus actinomycetemcomitans.				[4]
Alcaligenes faecalis (beta-proteobacteria)			MIC00059
Description	The abundance of Alcaligenaceae is associated with IgG immune responses.				[5]
Bacillus anthracis (firmicutes)			MIC00120
Description	Human IgG could response to peptidoglycan (PGN) from Bacillus anthracis.				[6]
Bacillus lentus (firmicutes)			MIC00131
Description	Bacillus lentus can stimulate the formation of immunoglobulin G(IgG).				[7]
Bacteroides fragilis (CFB bacteria)			MIC00158
Description	Systemic IgG could bound to Bacteroides fragilis.				[2]
Bacteroides ovatus (CFB bacteria)			MIC00167
Description	Mice immunized with Bacteroides ovatus D-6 in the absence of adjuvants developed specific anti-TFa IgM and IgG antibodies which also bound to human cancer cells carrying TFa.				[8]
Bacteroides thetaiotaomicron (CFB bacteria)			MIC00179
Description	IgG could response to Bacteroides thetaiotaomicron.				[9]
Bifidobacterium animalis subsp. lactis (actinobacteria)			MIC00216
Description	The abundance of Bifidobacterium animalis subsp.lactis HN019 is associated with IgG immune response.				[10]
Blautia producta (firmicutes)			MIC00981
Description	The abundance of Peptostreptococcus productus is associated with IgM response.				[11]
Burkholderia pseudomallei (beta-proteobacteria)			MIC00287
Description	Sera from mice with enlarged spleens exhibited moderate IgG titers against Burkholderia pseudomallei.				[12]
Campylobacter jejuni (epsilon-proteobacteria)			MIC00307
Description	Campylobacter jejuni ninfection induced production of IgG autoantibodies against ganglioside GM1 and caused complement-mediated motor nerve injury.				[13]
Campylobacter rectus (epsilon-proteobacteria)			MIC00313
Description	IgG immune responses is associated with Campylobacter rectus.				[4]
Candida albicans (budding yeasts)			MIC00317
Description	IgG is raised and protected from the intravaginal challenge with Candida albicans.				[14]
Capnocytophaga ochracea (CFB bacteria)			MIC00328
Description	The activity of proteolytic enzymes from Capnocytophaga ochracea could effect enzymolysis of human immunoglobulin G(lgG).				[15]
Citrobacter rodentium (enterobacteria)			MIC00366
Description	Immunoblotting with bacterial lysates using sera from Tlr2 / Tlr4 / mice showed reduced IgG in Tlr2 / Tlr4 / sera that recognized antigens produced by fecal bacteria, symbiotic bacteria Eescherichia coli and Klebsiella pneumoniae, as well as the gram-negative enteric pathogens Salmonella enterica serovar Typhimurium (Salmonella) and Citrobacter rodentium.				[16]
Clonorchis sinensis (firmicutes)			MIC01834
Description	The intensity of Clonorchis sinensis infection is associated with the positive rate of IgG.				[17]
Clostridioides difficile (firmicutes)			MIC00396
Description	Serum IgG and IgM antibodies to SLPs have been observed in both Clostridium difficile patients and asymptomatic carriers.				[18]
Coprococcus sp. (firmicutes)			MIC00444
Description	IgG immune responses is associated with Coprococcus.				[19]
Corynebacterium diphtheriae (actinobacteria)			MIC00452
Description	The abundance of Corynebacterium diphtheriae is associated with IgG immune response.				[20]
Delftia acidovorans (beta-proteobacteria)			MIC00479
Description	Delftia could be preferentially enriched in the IgG-targeted fraction of the microbiota.				[2]
Enterococcus faecalis (firmicutes)			MIC00548
Description	Systemic IgG could bound to Enterococcus faecalis.				[2]
Enterococcus hirae (firmicutes)			MIC00551
Description	IgG could response to Enterococcus hirae.				[9]
Escherichia coli (enterobacteria)			MIC00516
Description	The 50-g dose of double mutant heat-labile enterotoxin (dmLT) of Enterotoxigenic Escherichia coli recipients trended toward stronger responses than the 100-g dose recipients by serum IgG (67% versus 33%, p-value= 0.22).				[21]
Eubacterium nodatum (firmicutes)			MIC01812
Description	Eubacterium nodatum is associated with IgG response.				[4]
Eubacterium saphenum (firmicutes)			MIC00579
Description	The abundance of Eubacterium saphenum is associated with IgG immune response.				[22]
Finegoldia magna (firmicutes)			MIC00596
Description	The abundance of Peptococcus is associated with IgG immune responses.				[23]
Flavonifractor plautii (firmicutes)			MIC01414
Description	Flavonifractor is associated with IgG response.				[19]
Fusobacterium varium (fusobacteria)			MIC00621
Description	The abundance of Fusobacterium varium is associated with IgG immune response.				[24]
Glaesserella parasuis (gamma-proteobacteria)			MIC00654
Description	Haemophilus parasuis infection could active a humoral immune response, which is frequently associated with the development of a transient IgM response followed by a solid and progressively increasing IgG antibody response.				[25]
Granulicatella adiacens (firmicutes)			MIC00645
Description	IgG immune responses is associated with Granulicatella.				[19]
Haemophilus ducreyi (gamma-proteobacteria)			MIC00650
Description	The abundance of Haemophilus ducreyi is associated with IgG immune response.				[26]
Helicobacter pylori (epsilon-proteobacteria)			MIC00669
Description	We found that the rate of IgG anti-Helicobacter pylori seropositivity was significantly improved in IgA nephropathy.				[27]
Histophilus somni (gamma-proteobacteria)			MIC00655
Description	IgG antibodies recognize primarily a 40 kDa outer membrane protein (OMP) in whole cell Haemophilus somnus preparations.				[28]
Klebsiella aerogenes (enterobacteria)			MIC00530
Description	Enterobacter aerogenes strains could produce immunoglobulin G (IgG) antibody which can recognized Klebsiella strains.				[29]
Klebsiella pneumoniae (enterobacteria)			MIC01405
Description	Immunoblotting with bacterial lysates using sera from Tlr2 / Tlr4 / mice showed reduced IgG in Tlr2 / Tlr4 / sera that recognized antigens produced by fecal bacteria, symbiotic bacteria Eescherichia coli and Klebsiella pneumoniae, as well as the gram-negative enteric pathogens Salmonella enterica serovar Typhimurium (Salmonella) and Citrobacter rodentium.				[16]
Lactobacillus casei (firmicutes)			MIC00707
Description	Lactobacillus casei is associated with IgG immune responses.				[30]
Lactobacillus kefiranofaciens (firmicutes)			MIC00723
Description	The abundance of Lactobacillus kefiranofaciens is associated with IgG.				[31]
Lactobacillus zeae (firmicutes)			MIC00738
Description	Lactobacillus zeae is associated with IgG immune responses.				[32]
Leuconostoc mesenteroides (firmicutes)			MIC00766
Description	Leuconostoc mesenteroides is associated with IgG immune responses.				[33]
Methanobrevibacter smithii (euryarchaeotes)			MIC00792
Description	The abundance of Methanobrevibacter smithii is associated with IgG immune response.				[34]
Mycobacterium kansasii (actinobacteria)			MIC01785
Description	Cross-reactive IgG could response to MTB-PPD for Mycobacterium kansasii infection.				[35]
Mycoplasma arthritidis (tenericutes)			MIC00863
Description	The abundance of Mycoplasma arthritidis is associated with IgG immune response.				[36]
Mycoplasma capricolum subsp. capripneumoniae (mycoplasmas)			MIC00865
Description	Mycoplasma capricolum subsp.capripneumoniae is associated with IgG immune responses.				[37]
Mycoplasma conjunctivae (tenericutes)			MIC00867
Description	Mycoplasma conjunctivae infection elicits a strong immune IgG response.				[38]
Mycoplasma pulmonis (mycoplasmas)			MIC00876
Description	The abundance of Mycoplasma pulmonis is associated with IgG immune responses.				[39]
Mycoplasmatales (mycoplasmas)			MIC00878
Description	Many Mycoplasmatales is related to certain unique features of the mycoplasma and its interaction with the IgG immune responses.				[40]
Myxococcus xanthus (delta-proteobacteria)			MIC00880
Description	The abundance of Myxococcus xanthus is associated with IgG immune response.				[41]
Neisseria gonorrhoeae (beta-proteobacteria)			MIC00885
Description	Neisseria gonorrhoeae could induce IgG responce.				[42]
Neisseria meningitidis (beta-proteobacteria)			MIC00891
Description	IgG was used to remain free from Neisseria menningitidis infection.				[43]
Porphyromonas gingivalis (CFB bacteria)			MIC01000
Description	The activity of proteolytic enzymes from Porphyromonas gingivalis could effect enzymolysis of human immunoglobulin G(lgG).				[15]
Porphyromonas sp. (CFB bacteria)			MIC01003
Description	The infection of Porphyromonadaceae could increase the concentrations of serum IgG.				[44]
Prevotella copri (CFB bacteria)			MIC01010
Description	Prevotella copri was associated with IgG response in rheumatoid arthritis disease.				[45]
Prevotella oralis (CFB bacteria)			MIC00166
Description	The abundance of Prevotella oralis is associated with IgG immune response.				[46]
Pseudomonas aeruginosa (gamma-proteobacteria)			MIC01054
Description	An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model.				[47]
Pseudomonas oleovorans (gamma-proteobacteria)			MIC01060
Description	The abundance of Pseudomonas oleovorans is associated with IgG response.				[48]
Rhodococcus hoagii (actinobacteria)			MIC01092
Description	Opsonisation by specific IgG was necessary for efficient phagocytosis of Rhodococcus equi by alveolar macrophages.				[3]
Ruminococcus gnavus (firmicutes)			MIC01137
Description	The abundance of Ruminococcus gnavus is associated with IgG response.				[49]
Ruminococcus sp. (firmicutes)			MIC01140
Description	The abundance of Ruminococcaceae was associated with IgM response.				[50]
Saccharomyces cerevisiae (budding yeasts)			MIC01145
Description	Saccharomyces cerevisiae is associated with IgG response.				[51]
Salmonella enterica (enterobacteria)			MIC01150
Description	Immunoblotting with bacterial lysates using sera from Tlr2 / Tlr4 / mice showed reduced IgG in Tlr2 / Tlr4 / sera that recognized antigens produced by fecal bacteria, symbiotic bacteria Eescherichia coli and Klebsiella pneumoniae, as well as the gram-negative enteric pathogens Salmonella enterica serovar Typhimurium (Salmonella) and Citrobacter rodentium.				[16]
Salmonella enterica subsp. enterica (enterobacteria)			MIC01154
Description	Immunoblotting with bacterial lysates using sera from Tlr2 / Tlr4 / mice showed reduced IgG in Tlr2 / Tlr4 / sera that recognized antigens produced by fecal bacteria, symbiotic bacteria Eescherichia coli and Klebsiella pneumoniae, as well as the gram-negative enteric pathogens Salmonella enterica serovar Typhimurium (Salmonella) and Citrobacter rodentium.				[16]
Serratia fonticola (enterobacteria)			MIC01169
Description	Serratia could be preferentially enriched in the IgG-targeted fraction.				[2]
Staphylococcus aureus (firmicutes)			MIC01208
Description	The abundance of Staphylococcus aureus is associated with IgG response.				[52]
Staphylococcus epidermidis (firmicutes)			MIC01214
Description	Staphylococcus epidermidis was associated with IgG response.				[53]
Staphylococcus gallinarum (firmicutes)			MIC01774
Description	Staphylococcus gallinarum was associated with IgG response.				[54]
Staphylococcus sciuri (firmicutes)			MIC01222
Description	Staphylococcus sciuri was associated with IgG response.				[54]
Streptococcus equi (firmicutes)			MIC01249
Description	The abundance of Streptococcus equi is associated with IgG response.				[55]
Streptococcus pneumoniae (firmicutes)			MIC01263
Description	IgG could response to pneumococcal capsular polysaccharide (PCP).				[56]
Streptococcus pyogenes (firmicutes)			MIC01267
Description	The SpeB protease from Streptococcus pyogenes could digest IgGs.				[57]
Tannerella forsythia (CFB bacteria)			MIC01305
Description	Tannerella forsythia is associated with IgG response.				[4]
Toxocara canis (nematodes)			MIC01800
Description	Toxocara canis-infected dogs exhibited higher levels of IgG and IgE levels against Toxocara canis.				[58]
Treponema denticola (spirochetes)			MIC01322
Description	Treponema denticola is associated with IgG response.				[4]
Vibrio cholerae (gamma-proteobacteria)			MIC01369
Description	Vibrio choleraeis was associated with IgM response.				[59]
Yersinia pestis (enterobacteria)			MIC01401
Description	Yersinia pestis is associated with IgG response.				[60]

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