Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01267)
MIC Name Streptococcus pyogenes (firmicutes)
MIC Synonyms Micrococcus scarlatinae
Body Site Skin
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: Streptococcus pyogenes
Oxygen Sensitivity Aerotolerant
Microbial Metabolism Saccharolytic; Respiratory or Fermentative
Gram Positive
Host Relationship Opportunistic pathogen
Genome Size (bp) 1765123
No. of Coding Genes 1775
No. of Non-Coding Genes 85
No. of Small Non-Coding Genes 85
No. of Gene Transcripts 1860
No. of Base Pairs 1844804
Description Streptococcus pyogenes is a species of Gram-positive, aerotolerant bacterium in the genus Streptococcus. It is a significant cause of human disease, most often associated with infections of the respiratory tract, blood and skin.
External Links Taxonomy ID
1314
Genome Assembly ID
ASM74301v1
GOLD Organism ID
Go0005318
Disease Relevance
          Respiratory infection  [ICD-11: CA45]
             Description Streptococcus pyogenes was associated with respiratory tract infection. [1]
Host Genetic Factors (HGFs)
          hsa-miR-SSI1-281
             HGF ID HGF0704 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description Streptococcus pyogenes releases miR-SSI1-281, which leads to activation of neutrophil phagocytosis in the host. [2]
          hsa-miR-SSI1-221
             HGF ID HGF0703 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description Streptococcus pyogenes releases miR-SSI1-221, which leads to activation of neutrophil phagocytosis in the host. [2]
Host Immune Factors (HIFs)
          C-X-C motif chemokine 14
             HIF ID HIFM0077 HIF Info       Class Antimicrobial peptide (AMP)
             Description The expression of CXCL14 is completely degraded by the cysteine proteinase SpeB from a strictly human pathogen Streptococcus pyogenes. [3]
          Bradykinin
             HIF ID HIFM0160 HIF Info       Class Antimicrobial peptide (AMP)
             Description Streptococcus pyogenes can bind and assemble the components of the contact system through regulatory affinity to lead to activation and bradykinin release. [4]
          SgII peptide A
             HIF ID HIFM0327 HIF Info       Class Antimicrobial peptide (AMP)
             Description SgII peptide A exhibited antibacterial activity in CFU assay in a concentration of 0.32 M against Streptococcus pyogenes. [5]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Streptococcus pyogenes induced inflammatory cytokines production of IL-6. [6]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description Streptococcus pyogenes-induced production of inflammatory cytokines, including TNF and IL-6, by murine bone marrow-derived macrophages and conventional dendritic cells is entirely dependent on the signaling adaptor MyD88. [6]
          Dendritic cells
             HIF ID HIFC0003 HIF Info       Class Dendritic cells (DCs)
             Description relative abundances of Streptococcus pyogenes is associated with dendritic cells response. [6]
          Immunoglobulin alpha Fc receptor
             HIF ID HIFM0097 HIF Info       Class Fc Receptor (FCR)
             Description Enhanced in vitro uptake of Streptococcus pneumonia by neutrophils after targeting of FcRI(CD89) has been demonstrated. [7]
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description The SpeB protease from Streptococcus pyogenes could digest IgGs. [8]
          Macrophages
             HIF ID HIFC0020 HIF Info       Class Macrophages (Mac)
             Description Streptococcus pyogenes is associated with macrophages response. [6]
          Toll like receptor signaling pathway
             HIF ID HIFP0043 HIF Info       Class Signaling pathway (SP)
             Description TLR pathways could abolishe dendritic cells infected with Streptococcus pyogenes. [6]
          T-cell-specific surface glycoprotein CD28
             HIF ID HIFM0046 HIF Info       Class T-cell receptor (TCR)
             Description A peptide antagonist of CD28 signaling attenuates toxic shock and necrotizing soft-tissue infection induced by Streptococcus pyogenes. [9]
          Toll-like receptor 2
             HIF ID HIFM0217 HIF Info       Class Toll-like receptor (TLR)
             Description The blockage of phagocytosis almost abolished responses of TLR2-deficient cells to Streptococcus pyogenes infection(multiplicity of infection=50). [6]
          Toll-like receptor 13
             HIF ID HIFM0245 HIF Info       Class Toll-like receptor (TLR)
             Description Innate immune response to Streptococcus pyogenes depends on the Combined Activation of TLR13 and TLR2 [6]
Environmental Factor(s)
             Disbiome ID
      998
             gutMDisorder ID
      gm0624
             aBiofilm Organism
      Streptococcus pyogenes
References
1 In vitro activity of josamycin against Streptococcus pyogenes isolated from patients with upper respiratory tract infections in France. Med Mal Infect. 2015 Jul;45(7):293-6. doi: 10.1016/j.medmal.2015.04.009. Epub 2015 Jun 6.
2 MicroRNA fragments derived from Streptococcus pyogenes enable activation of neutrophil phagocytosis: in vitro study. Microbes Infect. 2013 Mar;15(3):212-8. doi: 10.1016/j.micinf.2012.11.009. Epub 2012 Dec 6.
3 CXCL14 as an emerging immune and inflammatory modulator.J Inflamm (Lond). 2016 Jan 5;13:1. doi: 10.1186/s12950-015-0109-9. eCollection 2016.
4 Interaction of Bacteroides fragilis and Bacteroides thetaiotaomicron with the kallikrein-kinin system.Microbiology. 2011 Jul;157(Pt 7):2094-2105. doi: 10.1099/mic.0.046862-0. Epub 2011 Apr 28.
5 The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins.J Immunol. 2008 Sep 1;181(5):3413-21. doi: 10.4049/jimmunol.181.5.3413.
6 Innate immune response to Streptococcus pyogenes depends on the combined activation of TLR13 and TLR2. PLoS One. 2015 Mar 10;10(3):e0119727. doi: 10.1371/journal.pone.0119727. eCollection 2015.
7 The human immunoglobulin A Fc receptor FcRI: a multifaceted regulator of mucosal immunity. Mucosal Immunol. 2011 Nov;4(6):612-24. doi: 10.1038/mi.2011.36. Epub 2011 Sep 21.
8 Generating and Purifying Fab Fragments from Human and Mouse IgG Using the Bacterial Enzymes IdeS, SpeB and Kgp.Methods Mol Biol. 2017;1535:319-329. doi: 10.1007/978-1-4939-6673-8_21.
9 A peptide antagonist of CD28 signaling attenuates toxic shock and necrotizing soft-tissue infection induced by Streptococcus pyogenes.J Infect Dis. 2013 Jun 15;207(12):1869-77. doi: 10.1093/infdis/jit104. Epub 2013 Mar 14.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.