Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0160)
HIF Name
Bradykinin
HIF Synonym(s)
Bradykinin, Kallidin I
HIF Classification
Antimicrobial peptide (AMP)
Molecular Function
Protease inhibitor; Thiol protease inhibitor; Vasoactive; Vasodilator
Description Bradykinin has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system. [1]
Pfam Cystatin domain (PF00031 )
Pathway African trypanosomiasis (hsa05143 )
Chagas disease (American trypanosomiasis) (hsa05142 )
Complement and coagulation cascades (hsa04610 )
Inflammatory mediator regulation of TRP channels (hsa04750 )
Neuroactive ligand-receptor interaction (hsa04080 )
Pathways in cancer (hsa05200 )
Regulation of actin cytoskeleton (hsa04810 )
Sphingolipid signaling pathway (hsa04071 )
cGMP-PKG signaling pathway (hsa04022 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
KNG1_HUMAN
APD ID
AP01472
Microbe Species (MIC) Regulated by This HIF
         Bacteroides fragilis (CFB bacteria) MIC00158
             Description Bacteroides fragilis induced release of bradykinin through regulatory affinity from high-molecular-mass kininogen in human plasma. [2]
         Bacteroides thetaiotaomicron (CFB bacteria) MIC00179
             Description Bacteroides thetaiotaomicron induced release of bradykinin through regulatory affinity to from high-molecular-mass kininogen in human plasma. [2]
         Salmonella sp. (enterobacteria) MIC01149
             Description Salmonella can bind and assemble the components of the contact system through regulatory affinity to lead to activation and bradykinin release. [2]
         Staphylococcus aureus (firmicutes) MIC01208
             Description Staphylococcus aureus can bind and assemble the components of the contact system through regulatory affinity to lead to activation and bradykinin release. [2]
         Streptococcus pyogenes (firmicutes) MIC01267
             Description Streptococcus pyogenes can bind and assemble the components of the contact system through regulatory affinity to lead to activation and bradykinin release. [2]
References
1 APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2 Interaction of Bacteroides fragilis and Bacteroides thetaiotaomicron with the kallikrein-kinin system.Microbiology. 2011 Jul;157(Pt 7):2094-2105. doi: 10.1099/mic.0.046862-0. Epub 2011 Apr 28.

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