Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00158)
MIC Name Bacteroides fragilis (CFB bacteria)
MIC Synonyms Fusiformis fragilis
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
Species: Bacteroides fragilis
Oxygen Sensitivity Anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Negative
Host Relationship Commensal
Genome Size (bp) 5188967
No. of Coding Genes 4381
No. of Non-Coding Genes 80
No. of Small Non-Coding Genes 80
No. of Gene Transcripts 4461
No. of Base Pairs 5469625
Description Bacteroides fragilis is an obligately anaerobic, Gram-negative, rod-shaped bacterium. It is part of the normal microbiota of the human colon and is generally commensal, but can cause infection if displaced into the bloodstream or surrounding tissue following surgery, disease or trauma.
External Links Taxonomy ID
817
Genome Assembly ID
DCMOUH0085B_1.0
GOLD Organism ID
Go0004681
Disease Relevance
          Bacterial meningitis  [ICD-11: 1D01]
             Description Bacteroides fragilis YCH 46 was associated with meningitis. [1]
          Coeliac disease  [ICD-11: DA95]
             Description Bacteroides fragilis was associated with increased genetic risk of developing coeliac disease in infants. [2]
          Colorectal cancer  [ICD-11: 2B91]
             Description Bacteroides fragilis was associated with colorectal cancer. [3]
          Infectious endocarditis  [ICD-11: BB40]
             Description Bacteroides fragilis YCH 46 was associated with endocarditis. [4]
          Inflammatory bowel disease  [ICD-11: DD72]
             Description Bacteroides fragilis was typically decreased in inflammatory bowel disease patients. [5]
          Meningococcal disease  [ICD-11: 1C1C]
             Description Bacteroides fragilis YCH 46 was associated with bacteraemia. [6]
          Pericarditis  [ICD-11: BB20]
             Description Bacteroides fragilis YCH 46 was associated with Pericarditis. [7]
          Sepsis  [ICD-11: 1G41]
             Description Bacteroides fragilis YCH 46 was associated with intra-abdominal sepsis. [8]
          Septic arthritis  [ICD-11: FA10]
             Description Bacteroides fragilis YCH 46 was associated with septic arthritis. [9]
          Vibrio mimicus gastroenteritis  [ICD-11: 1A40]
             Description Bacteroides fragilis YCH 46 was associated with colitis. [10]
Host Genetic Factors (HGFs)
          CD44
             HGF ID HGF2333 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of CD44 significantly decreased the abundance of Bacteroides sp. 2_1_16 (p-value<0.05). [11]
          AMY1A
             HGF ID HGF2311 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description The higher AMY1-CN has been associated with the abundance of Bacteroides fragilis. [12]
          lncRNA1
             HGF ID HGF0625 HGF Info       Class Non-coding RNA: Long Non-coding (ncRNA-lncRNA)
             Description Bacteroides fragilis-associated lncRNA1 (BFAL1) in colorectal cancer tissues mediated ETBF carcinogenesis. [13]
          hsa-miR-155-5p
             HGF ID HGF0243 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description Bacteroides fragilis-associated lncRNA1 regulated RHEB expression by miR-155-5p. [13]
          hsa-miR-200a-3p
             HGF ID HGF0213 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description Bacteroides fragilis-associated lncRNA1 regulated RHEB expression by miR-200a-3p. [13]
          hsa-let-7b-5p
             HGF ID HGF0300 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of hsa-let-7b-5p could be altered by Bacteroides fragilis. [14]
          rs571312
             HGF ID HGF2159 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The variant gene MC4R of innate immunity rs571312 is significantly associated with the abundance of gut micriobiota Bacteroides fragilis (p-value=0.0010). [15]
          rs1483022
             HGF ID HGF1902 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The rs1483022 SNP is significantly associated with the abundance of Bacteroides fragilis (p-value=2.86E-05). [16]
          rs11742570
             HGF ID HGF2603 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs11742570 SNP is associated with the abundance of Bacteroides fragilis. [17]
          rs10065637
             HGF ID HGF2604 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs10065637 SNP is associated with the abundance of Bacteroides fragilis. [17]
          rs3024505
             HGF ID HGF2605 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs3024505 SNP is associated with the abundance of Bacteroides fragilis. [17]
          rs13204742
             HGF ID HGF2560 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs13204742 SNP is associated with the abundance of Bacteroides fragilis. [17]
          rs11564258
             HGF ID HGF2606 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs11564258 SNP is associated with the abundance of Bacteroides fragilis. [17]
          rs6920220
             HGF ID HGF2532 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs6920220 SNP is associated with the abundance of Bacteroides fragilis. [17]
Host Immune Factors (HIFs)
          Bradykinin
             HIF ID HIFM0160 HIF Info       Class Antimicrobial peptide (AMP)
             Description Bacteroides fragilis induced release of bradykinin through regulatory affinity from high-molecular-mass kininogen in human plasma. [18]
          Perforin
             HIF ID HIFM0320 HIF Info       Class Antimicrobial peptide (AMP)
             Description Bacteroides fragilis could use MACPF (membrane attack complex/perforin) toxinsBSAP-1 and BSAP-2, respectivelyfor intraspecies killing. [19]
          Ubiquitin
             HIF ID HIFM0334 HIF Info       Class Antimicrobial peptide (AMP)
             Description The bacterium Bacteroides fragilis is the only bacterium known to encode a homologue of eukaryotic ubiquitin. [20]
          B cells
             HIF ID HIFC0001 HIF Info       Class B cells (BCs)
             Description Bacteroides fragilis polysaccharide A induces IL-10 secreting T cells that prevent viral encephalitis. [21]
          Cytotoxic T-lymphocyte-associated protein 4
             HIF ID HIFM0068 HIF Info       Class Checkpoint molecule (CM)
             Description The efficacy of CTLA-4 blockade therapy against melanoma is associated with some enteric bacteria,such as Bacteroides fragilis. [22]
          Interferon-10
             HIF ID HIFM0128 HIF Info       Class Cytokine (Cyt)
             Description Bacteroides fragilis could induce IL-10-producing regulatory T(Treg) cells. [23]
          Interleukin-17A
             HIF ID HIFM0134 HIF Info       Class Cytokine (Cyt)
             Description Bacteroides fragilis induced infiltration of the colonic lamina propria with IL-17-producing CD3+CD4+ T-cells. [24]
          CD103+ dendritic cells
             HIF ID HIFC0006 HIF Info       Class Dendritic cells (DCs)
             Description Intestinal CD103+ dendritic cells are induced by oral administration of polysaccharide A from Bacteroides fragilis. [25]
          Immunoglobulin G2
             HIF ID HIFM0268 HIF Info       Class Immunoglobulin (Ig)
             Description Prediagnosis IgG2 titers could be against the Bacteroides fragilis strain. [26]
          Immunoglobulin G1
             HIF ID HIFM0269 HIF Info       Class Immunoglobulin (Ig)
             Description IgG1 could be against Bacteroides fragilis. [27]
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description Systemic IgG could bound to Bacteroides fragilis. [28]
          Immunoglobulin E
             HIF ID HIFM0271 HIF Info       Class Immunoglobulin (Ig)
             Description high Bacteroides fragilis is positively associated with IgE. [29]
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description IgA has regulatory affinity which could bind to Bacteroides fragilis. [30]
          M1 macrophages
             HIF ID HIFC0019 HIF Info       Class Macrophages (Mac)
             Description Bacteroides fragilis was significantly decreased with methotrexate treatment(P < 0.01) and tended to decrease proportionately with increasing M1 macrophages density. [31]
          M2 macrophages
             HIF ID HIFC0124 HIF Info       Class Macrophages (Mac)
             Description Gavage with Bacteroides fragilis mitigated the increase in the M1/M2macrophages ratio as a result of MTX administration in both MLNs and spleen. [31]
          T cells
             HIF ID HIFC0002 HIF Info       Class T cells (TCs)
             Description Polysaccharide A derived from Bacteroides fragilis induced Treg cell accumulation by engaging with Toll-like receptor 2 expressed by T cells. [32]
          Regulatory T cells
             HIF ID HIFC0030 HIF Info       Class T cells (TCs)
             Description Bacteroides fragilis induces IL-10-producing regulatory T (Treg) cells in the colon via capsular expression of polysaccharide A. [23]
          CD4+ regulatory T cells
             HIF ID HIFC0034 HIF Info       Class T cells (TCs)
             Description Bacteroides fragilis is associated with CD4+ T cells responses. [23]
          T helper type 17 cells
             HIF ID HIFC0080 HIF Info       Class T cells (TCs)
             Description Polysaccharide A of Bacteroides fragilis resulted in interleukin 10 (IL-10) feedback by intestinal T cells, which restrained the accumulation of TH17 cells and potentially damaged the mucosal barrier. [33]
          CD39+Foxp3+ regulatory T cells
             HIF ID HIFC0183 HIF Info       Class T cells (TCs)
             Description A commensal symbiotic factor derived from Bacteroides fragilis promotes human CD39+Foxp3+ T cells and Treg function. [34]
          IL10+FOXP3+CD4+ regulatory T cells
             HIF ID HIFC0187 HIF Info       Class T cells (TCs)
             Description Bacteroides fragilis is related to the IL10+FOXP3+CD4+ Treg cells in the colon. [35]
          Foxp3 regulatory T cells
             HIF ID HIFC0196 HIF Info       Class T cells (TCs)
             Description Foxp3 Tregs were shown to be responsible for attenuating host Th17 cells in the gut, which would otherwise limit Bacteroides fragilis colonization. [34]
          NRP1 RORt+ regulatory T cells
             HIF ID HIFC0224 HIF Info       Class T cells (TCs)
             Description Bacteroides fragilis has been shown to induce the accumulation number of NRP1RORt+ pTreg cells. [35]
Environmental Factor(s)
             Disbiome ID
      240
             gutMDisorder ID
      gm0082
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