General Information of HIF (ID: HIFM0268)
HIF Name	Immunoglobulin G2
HIF Synonym(s)	IgG2
HIF Classification	Immunoglobulin (Ig)
Description	Immunoglobulin G2(IgG2) responses to bacterial capsular polysaccharide antigens can be almost completely restricted to IgG2(9, 1113), and IgG2 deficiency may result in the virtual absence of IgG anti-carbohydrate antibodies.				[1]

Microbe Species (MIC) Regulated by This HIF
Actinobacillus pleuropneumoniae (gamma-proteobacteria)			MIC00026
Description	The abundance of Actinobacillus pleuropneumoniae is associated with IgG2 response.				[2]
Bacteroides fragilis (CFB bacteria)			MIC00158
Description	Prediagnosis IgG2 titers could be against the Bacteroides fragilis strain.				[3]
Brachyspira hyodysenteriae (spirochaetes)			MIC00258
Description	Brachyspira infection could increase antigen-specific IgG2a responses to the resident microflora.				[4]
Capnocytophaga ochracea (CFB bacteria)			MIC00328
Description	The activity of proteolytic enzymes from Capnocytophaga ochracea could effect enzymolysis of human immunoglobulin G2(lgG2).				[5]
Erysipelothrix rhusiopathiae (firmicutes)			MIC00559
Description	The abundance of Erysipelothrix is associated with IgG2 response.				[6]
Haemophilus influenzae (gamma-proteobacteria)			MIC00652
Description	Haemophilus sp. is associated with IgG2 response.				[7]
Haemophilus sp. (gamma-proteobacteria)			MIC01768
Description	The abundance of Haemophilus sp. is associated with IgG2 response.				[7]
Helicobacter bilis (epsilon-proteobacteria)			MIC00663
Description	Helicobacter bilis infection could increase antigen-specific IgG2a responses to the resident microflora.				[4]
Helicobacter cinaedi (epsilon-proteobacteria)			MIC00665
Description	IgG2a could response to Helicobacter cinaedi infection.				[8]
Histophilus somni (gamma-proteobacteria)			MIC00655
Description	The abundance of Histophilus somni is associated with IgG2.				[9]
Parascardovia denticolens (actinobacteria)			MIC00858
Description	The abundance of Mycobacterium ulcerans is associated with IgG2 response.				[10]
Neisseria lactamica (beta-proteobacteria)			MIC00888
Description	Neisseria lactamica was associated with IgG2 response.				[11]
Neisseria meningitidis (beta-proteobacteria)			MIC00891
Description	IgG2 could response to Meningococcus.				[7]
Porphyromonas gingivalis (CFB bacteria)			MIC01000
Description	The activity of proteolytic enzymes from Porphyromonas gingivalis could effect enzymolysis of human immunoglobulin G2(lgG2).				[5]
Roseburia faecis (firmicutes)			MIC01116
Description	IgG2 could response against Roseburia faecis.				[3]
Saccharomyces cerevisiae (budding yeasts)			MIC01145
Description	IgG2 could be against Saccharomyces cerevisiae.				[12]
Salmonella enterica subsp. enterica (enterobacteria)			MIC01154
Description	The levels of IgG2a increased during Salmonella typhimurium infection.				[13]
Staphylococcus aureus (firmicutes)			MIC01208
Description	Staphylococcus aureus is associated with IgG2 response.				[14]
Streptobacillus moniliformis (fusobacteria)			MIC01235
Description	Streptobacillus moniliformis was associated with IgG2b response.				[15]
Streptococcus gallolyticus (firmicutes)			MIC01251
Description	Prediagnosis IgG2 titers could be against the Streptococcus gallolyticus strain.				[3]
Streptococcus pneumoniae (firmicutes)			MIC01263
Description	IgG2 could response to Streptococcus pneumoniae.				[16]

References
1	IgG subclasses and allotypes: from structure to effector functions. Front Immunol. 2014 Oct 20;5:520. doi: 10.3389/fimmu.2014.00520. eCollection 2014.
2	Anti-haemolysin IgG1 to IgG2 ratios correlate with haemolysin neutralization titres and lung lesion scores in Actinobacillus pleuropneumoniae infected pigs.Vaccine. 1998 Dec;16(20):1971-5. doi: 10.1016/s0264-410x(98)00120-0.
3	Association of HLA-dependent islet autoimmunity with systemic antibody responses to intestinal commensal bacteria in children.Sci Immunol. 2019 Feb 1;4(32):eaau8125. doi: 10.1126/sciimmunol.aau8125.
4	Induction of differential immune reactivity to members of the flora of gnotobiotic mice following colonization with Helicobacter bilis or Brachyspira hyodysenteriae. Microbes Infect. 2006 May;8(6):1602-10. doi: 10.1016/j.micinf.2006.01.019. Epub 2006 Apr 18.
5	Immunoglobulin-degrading enzymes in localized juvenile periodontitis.J Periodontal Res. 1992 May;27(3):176-83. doi: 10.1111/j.1600-0765.1992.tb01666.x.
6	IgGs containing - and -type light chains and of all subclasses (IgG1-IgG4) from the sera of patients with autoimmune diseases and viral and bacterial infections hydrolyze DNA.J Mol Recognit. 2012 Jul;25(7):383-92. doi: 10.1002/jmr.2185.
7	Are there any clinical indications for measuring IgG subclasses. Ann Clin Biochem. 2002 Jul;39(Pt 4):374-7. doi: 10.1258/000456302760042678.
8	Alkyl hydroperoxide reductase is required for Helicobacter cinaedi intestinal colonization and survival under oxidative stress in BALB/c and BALB/c interleukin-10-/- mice. Infect Immun. 2012 Mar;80(3):921-8. doi: 10.1128/IAI.05477-11. Epub 2011 Dec 19.
9	Experimental abortion and the systemic immune response to "Haemophilus somnus" in cattle. Infect Immun. 1986 Nov;54(2):555-60.
10	Immune response to infection with Mycobacterium ulcerans. Infect Immun. 2001 Mar;69(3):1704-7. doi: 10.1128/IAI.69.3.1704-1707.2001.
11	The PorB porin from commensal Neisseria lactamica induces Th1 and Th2 immune responses to ovalbumin in mice and is a potential immune adjuvant. Vaccine. 2008 Feb 6;26(6):786-96. doi: 10.1016/j.vaccine.2007.11.080. Epub 2007 Dec 26.
12	Anti-food and anti-microbial IgG subclass antibodies in inflammatory bowel disease.Scand J Gastroenterol. 2016 Dec;51(12):1453-1461. doi: 10.1080/00365521.2016.1205130. Epub 2016 Jul 25.
13	Salmonella Typhimurium, the major causative agent of foodborne illness inactivated by a phage lysis system provides effective protection against lethal challenge by induction of robust cell-mediated immune responses and activation of dendritic cells. Vet Res. 2017 Oct 25;48(1):66. doi: 10.1186/s13567-017-0474-x.
14	Passive acquisition of anti-Staphylococcus aureus antibodies by newborns via transplacental transfer and breastfeeding, regardless of maternal colonization.Clinics (Sao Paulo). 2016 Dec 1;71(12):687-694. doi: 10.6061/clinics/2016(12)02.
15	Comparative analysis of clinics, pathologies and immune responses in BALB/c and C57BL/6 mice infected with Streptobacillus moniliformis. Microbes Infect. 2018 Feb;20(2):101-110. doi: 10.1016/j.micinf.2017.10.001. Epub 2017 Oct 10.
16	Measurement of the IgG2 response to Pneumococcal capsular polysaccharides may identify an antibody deficiency in individuals referred for immunological investigation.J Immunoassay Immunochem. 2017;38(5):514-522. doi: 10.1080/15321819.2017.1340897. Epub 2017 Jun 14.

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