Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00559)
MIC Name Erysipelothrix rhusiopathiae (firmicutes)
MIC Synonyms Bacterium rhusiopathiae
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Erysipelotrichia
Order: Erysipelotrichales
Family: Erysipelotrichaceae
Genus: Erysipelothrix
Species: Erysipelothrix rhusiopathiae
Oxygen Sensitivity Aerobe
Microbial Metabolism Respiratory
Gram Positive
Description Erysipelothrix rhusiopathiae is a facultative, non-spore-forming, non-acid-fast, small, Gram-positive bacillus.
External Links Taxonomy ID
1648
Genome Assembly ID
ASM16081v2
GOLD Organism ID
Go0520882
Disease Relevance
          Alcoholic hepatitis  [ICD-11: DB94]
             Description Erysipelotrichales was associated with alcoholic hepatitis. [1]
          Alzheimer disease  [ICD-11: 8A20]
             Description Erysipelotrichaceae was associated with alzheimer's disease . [2]
          Colorectal cancer  [ICD-11: 2B91]
             Description Erysipelotrichaceae was associated with colorectal cancer. [3]
          Inflammatory bowel disease  [ICD-11: DD72]
             Description Erysipelotrichaceae was associated with inflammatory bowel disease. [3]
Host Genetic Factors (HGFs)
          MUC2
             HGF ID HGF2331 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of MUC2 showed significantly increased abundance of Erysipelotrichaceae (p-value<0.05). [4]
          AMY1A
             HGF ID HGF2311 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description Gut microbiome Erysipelotrichaceae differs between high AMY1-CN and low AMY1-CN groups at the OTU Level (p-value<0.05). [5]
          rs17421787
             HGF ID HGF2075 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs17421787 SNP was significantly associated with the abundance of Erysipelotrichales (p-value=3.60E-8). [6]
          rs11877825
             HGF ID HGF2167 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs11877825 SNP was significantly associated with the abundance of Erysipelotrichales (p-value=2.82E-11). [6]
          rs73159316
             HGF ID HGF2005 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs73159316 SNP was significantly associated with the abundance of Erysipelotrichaceae bacterium (p-value<1.00E-08). [7]
          rs6923761
             HGF ID HGF1753 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The variant gene GLP1R of innate immunity rs6923761 is significantly associated with the abundance of gut micriobiota Erysipelotrichaceae (p-value=0.0360). [8]
          rs56126429
             HGF ID HGF2257 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs56126429 SNP was significantly associated with the abundance of Erysipelotrichaceae bacterium (p-value<1.00E-08). [7]
Host Immune Factors (HIFs)
          Interferon gamma
             HIF ID HIFM0260 HIF Info       Class Cytokine (Cyt)
             Description The splenocytes from mice inoculated with a recombinant Erysipelothrix rhusiopathiae strain significantly induced IFN-Gamma upon stimulation with concanavalin A, showing that the recombinant poIL-18 produced by Erysipelothrix rhusiopathiaehas biological activity in vivo. [9]
          Immunoglobulin M
             HIF ID HIFM0266 HIF Info       Class Immunoglobulin (Ig)
             Description Increases were seen in the concentrations of BALF IgA (but not IgG) and serum IgM against Mycoplasma hyopneumoniae and Erysipelothrix rhusiopathiae antigens, respectively. [9]
          Immunoglobulin G3
             HIF ID HIFM0267 HIF Info       Class Immunoglobulin (Ig)
             Description The abundance of Erysipelothrix is associated with IgG3 response. [10]
          Immunoglobulin G2
             HIF ID HIFM0268 HIF Info       Class Immunoglobulin (Ig)
             Description The abundance of Erysipelothrix is associated with IgG2 response. [10]
          Immunoglobulin G1
             HIF ID HIFM0269 HIF Info       Class Immunoglobulin (Ig)
             Description The abundance of Erysipelothrix is associated with IgG1 response. [10]
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description Increases were seen in the concentrations of BALF IgA (but not IgG) and serum IgM against Mycoplasma hyopneumoniae and Erysipelothrix rhusiopathiae antigens, respectively. [9]
          Immunoglobulin G4
             HIF ID HIFM0278 HIF Info       Class Immunoglobulin (Ig)
             Description IgG4 is associated with the abundance of Erysipelothrix. [10]
          Macrophages
             HIF ID HIFC0020 HIF Info       Class Macrophages (Mac)
             Description Macrophage expressed IL-18 in host defenses against Erysipelothrix rhusiopathiae infection. [9]
          Nuclear receptor ROR-beta
             HIF ID HIFM0204 HIF Info       Class Retinoic acid receptor (RAR)
             Description ROR-beta was upregulated after metronidazole treatment which caused substantial enrichment of the bacterial species Erysipelotrichales. [11]
Environmental Factor(s)
             Disbiome ID
      1282
             gutMDisorder ID
      gm0298
References
1 Rifaximin prevents ethanol-induced liver injury in obese KK-A(y) mice through modulation of small intestinal microbiota signature. Am J Physiol Gastrointest Liver Physiol. 2019 Nov 1;317(5):G707-G715. doi: 10.1152/ajpgi.00372.2018. Epub 2019 Sep 11.
2 Shifts in gut microbiota composition in an APP/PSS1 transgenic mouse model of Alzheimer's disease during lifespan. Lett Appl Microbiol. 2018 Jun;66(6):464-471. doi: 10.1111/lam.12882. Epub 2018 Apr 16.
3 Introducing the sporobiota and sporobiome. Gut Pathog. 2017 Jun 30;9:38. doi: 10.1186/s13099-017-0187-8. eCollection 2017.
4 The Dynamic Changes of Gut Microbiota in Muc2 Deficient Mice.Int J Mol Sci. 2018 Sep 18;19(9):2809. doi: 10.3390/ijms19092809.
5 Human Salivary Amylase Gene Copy Number Impacts Oral and Gut Microbiomes.Cell Host Microbe. 2019 Apr 10;25(4):553-564.e7. doi: 10.1016/j.chom.2019.03.001.
6 Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.Nat Genet. 2016 Nov;48(11):1396-1406. doi: 10.1038/ng.3695. Epub 2016 Oct 10.
7 Host genetic variation and its microbiome interactions within the Human Microbiome Project.Genome Med. 2018 Jan 29;10(1):6. doi: 10.1186/s13073-018-0515-8.
8 Variants in genes of innate immunity, appetite control and energy metabolism are associated with host cardiometabolic health and gut microbiota composition.Gut Microbes. 2020 May 3;11(3):556-568. doi: 10.1080/19490976.2019.1619440. Epub 2019 Jun 3.
9 Immunostimulatory effects of recombinant Erysipelothrix rhusiopathiae expressing porcine interleukin-18 in mice and pigs. Clin Vaccine Immunol. 2012 Sep;19(9):1393-8. doi: 10.1128/CVI.00342-12. Epub 2012 Jul 3.
10 IgGs containing - and -type light chains and of all subclasses (IgG1-IgG4) from the sera of patients with autoimmune diseases and viral and bacterial infections hydrolyze DNA.J Mol Recognit. 2012 Jul;25(7):383-92. doi: 10.1002/jmr.2185.
11 Metronidazole Causes Skeletal Muscle Atrophy and Modulates Muscle Chronometabolism. Int J Mol Sci. 2018 Aug 16;19(8):2418. doi: 10.3390/ijms19082418.

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