Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0204)
HIF Name
Nuclear receptor ROR-beta
HIF Synonym(s)
RAR related orphan receptor B, EIG15, NR1F2, ROR-BETA, RZR-BETA, RZRB, bA133M9.1
HIF Classification
Retinoic acid receptor (RAR)
Molecular Function
Activator; Developmental protein; DNA-binding; Receptor
Description Nuclear receptor ROR-beta(RORB) is a retinoic acid receptor-related orphan receptor,and is involved in many physiological processes, including regulation of metabolism, development and immunity as well as the circadian rhythm. [1]
Pfam Ligand-binding domain of nuclear hormone receptor (PF00104 )
Zinc finger, C4 type (two domains) (PF00105 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
RORB_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Erysipelothrix rhusiopathiae (firmicutes) MIC00559
             Description ROR-beta was upregulated after metronidazole treatment which caused substantial enrichment of the bacterial species Erysipelotrichales. [2]
         Proteobacteria (proteobacteria) MIC01037
             Description Alteration of the gut Proteobacteria resulted in increased expression of the effector gene Ror-beta. [2]
References
1 REV-ERB and ROR nuclear receptors as drug targets.Nat Rev Drug Discov. 2014 Mar;13(3):197-216. doi: 10.1038/nrd4100.
2 Metronidazole Causes Skeletal Muscle Atrophy and Modulates Muscle Chronometabolism. Int J Mol Sci. 2018 Aug 16;19(8):2418. doi: 10.3390/ijms19082418.

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