Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0260)
HIF Name
Interferon gamma
HIF Synonym(s)
Interferon Gamma, Immune Interferon, IFNG, IFG, IFI
HIF Classification
Cytokine (Cyt)
Description Interferon gamma, a T-cell lymphokine, may play a critical role in the effective clinical response to Mycobacterium tuberculosis. [1]
Microbe Species (MIC) Regulated by This HIF
         Bacteroides sp. (CFB bacteria) MIC00176
             Description The abundance of Bacteroidaceae was associated with the level of IFN-Gamma. [2]
         Barnesiella intestinihominis (CFB bacteria) MIC00192
             Description Barnesiella intestinihominis augmented the proportions of IFN-Gamma-producing. [3]
         Bifidobacterium adolescentis (actinobacteria) MIC00205
             Description Bifidobacterium adolescentis could inhibite IFN-Gamma production. [4]
         Bifidobacterium breve (actinobacteria) MIC00210
             Description At the species level, Bifidobacterium breve is associated with IFN-Gamma. [5]
         Bifidobacterium catenulatum (actinobacteria) MIC00211
             Description Bifidobacterium catenulatum can enhance IFN-Gamma production. [4]
         Bifidobacterium longum (actinobacteria) MIC00232
             Description Bifidobacterium longum could inhibite IFN-Gamma production. [4]
         Bordetella bronchiseptica (beta-proteobacteria) MIC00245
             Description Bordetella bronchiseptica could mediate inhibition of IFN-Gamma production. [6]
         Brachyspira hyodysenteriae (spirochaetes) MIC00258
             Description The abundance of Brachyspira bilis may be associated with IFN-Gamma. [7]
         Brucella canis (alpha-proteobacteria) MIC00269
             Description The abundance of Brucella canis is associated with IFN-Gamma. [8]
         Brucella ovis (alpha-proteobacteria) MIC00273
             Description The abundance of Brucella ovis is associated with IFN-Gamma. [9]
         Brucella suis (alpha-proteobacteria) MIC00275
             Description This impairment of Brucella suis multiplication is due to both soluble factors released from activated gammadeltaT-cells (including TNF-alpha and IFN-gamma) and to a contact-dependent cytotoxicity directed against the infected cells. [10]
         Burkholderia pseudomallei (beta-proteobacteria) MIC00287
             Description Increased expression of proinflammatory cytokines IFN-gamma was confined primarily to the area with the pathogen Burkholderia pseudomallei within pyogranulomatous lesions. [11]
         Campylobacter coli (epsilon-proteobacteria) MIC00301
             Description An in vitro model of Campylobacter coli infection using healthy human gut explant showed marked induction of IFN-gamma with a modest increase of IL-22 and IL-17A levels. [12]
         Campylobacter jejuni (epsilon-proteobacteria) MIC00307
             Description Campylobacter jejuni infection with either strain resulted in elevated colonic IL-6, TNF and IFN-Gamma secretion. [13]
         Chlamydia abortus (chlamydias) MIC00347
             Description The abundance of Chlamydia abortus is associated with IFN-Gamma. [14]
         Chlamydia felis (chlamydias) MIC00349
             Description The abundance of Chlamydia felis is associated with IFN-Gamma. [15]
         Chlamydia pneumoniae (chlamydias) MIC00350
             Description Chlamydophila pneumoniae could increase the level of IFN-Gamma. [16]
         Clostridioides difficile (firmicutes) MIC00396
             Description Clostridium difficile toxin could induce the production of IFN-Gamma. [17]
         Clostridium butyricum (firmicutes) MIC00388
             Description Clostridium butyricum CGMCC0313.1 decreases systemic inflammation primarily by reducing IFN-gamma+CD4+ T cells. [18]
         Clostridium leptum (firmicutes) MIC00402
             Description Related cytokines (IFN-Gamma, IL-4, IL-5, IL-13, IL-17A, IL-17F, IL-21, IL-23) could be decrease in the OVA-sensitized fed-Clostridium leptum adult mice. [19]
         Clostridium sp. (firmicutes) MIC00418
             Description Clostridium was associated with TNF-Gamma. [20]
         Coxiella burnetii (gamma-proteobacteria) MIC00467
             Description The abundance of Coxiella burnetii is associated with IFN-Gamma. [21]
         Deltaproteobacteria (delta-proteobacteria) MIC00480
             Description Deltaproteobacteria could increase IFN-Gamma. [22]
         Desulfovibrio vulgaris (delta-proteobacteria) MIC00502
             Description Desulfovibrio vulgaris triggerd nitric oxide production at levels similar to those stimulated by the cytokine gamma interferon (IFN-). [23]
         Ehrlichia chaffeensis (alpha-proteobacteria) MIC00523
             Description The abundance of Ehrlichia chaffeensis is associated with IFN-Gamma. [24]
         Enterococcus faecalis (firmicutes) MIC00548
             Description Enterococcus faecalis is associated with IFN-Gamma. [25]
         Erysipelothrix rhusiopathiae (firmicutes) MIC00559
             Description The splenocytes from mice inoculated with a recombinant Erysipelothrix rhusiopathiae strain significantly induced IFN-Gamma upon stimulation with concanavalin A, showing that the recombinant poIL-18 produced by Erysipelothrix rhusiopathiaehas biological activity in vivo. [26]
         Eubacterium saphenum (firmicutes) MIC00579
             Description After injection of Eubacterium saphenum, the production of IFN-Gamma in CD4+/CD8+ T cells is rather low. [27]
         Faecalibacterium prausnitzii (firmicutes) MIC00590
             Description At the species level, Faecalibacterium prausnitzii is associated with IFN-Gamma. [28]
         Glaesserella parasuis (gamma-proteobacteria) MIC00654
             Description Increased IL-1alpha expression in lung has been reported in pigs undergoing severe Glasser s disease following Haemophilus parasuis infection, whereas IL-4, IL-10, tumor necrosis factor (TNF)-alpha, and interferon (IFN)-gamma were expressed in significantly higher levels in spleen, pharyngeal lymph nodes, lung and brain of survivors. [29]
         Haemophilus ducreyi (gamma-proteobacteria) MIC00650
             Description The abundance of Haemophilus ducreyi is associated with IFN-Gamma. [30]
         Helicobacter acinonychis (epsilon-proteobacteria) MIC00662
             Description Infection with Helicobacter pylori leads to activation of both Th1 and Th17 cells with subsequent production of IFN-Gamma, IL-17, and TNF-Alpha. [31]
         Klebsiella aerogenes (enterobacteria) MIC00530
             Description The abundance of Enterobacter aerogenes is associated with IFN-Gamma. [32]
         Lachnospiraceae (firmicutes) MIC00695
             Description Lachnospiraceae was associated with IFN-gamma. [33]
         Lactobacillus casei (firmicutes) MIC00707
             Description Lactobacillus casei was associated with IFNs. [34]
         Lactobacillus helveticus (firmicutes) MIC01410
             Description Nevertheless, all three strains Lactobacillus paracasei OFS 0291, Lactobacillus helveticus OFS 1515 andLactobacillus fermentum DR9 alleviated proinflammatory cytokines TNF-Alpha, IFN-Gamma and IL-1Beta as well as IL-4, the Thelper (Th) 2 cell promoter in the gut. [35]
         Lactobacillus kefiranofaciens (firmicutes) MIC00723
             Description The abundance of Lactobacillus kefiranofaciens may be associated with IFN-Gamma. [36]
         Lactobacillus paracasei (firmicutes) MIC00726
             Description Lactobacillus paracasei could increase the level of IFN-Gamma. [37]
         Lactobacillus pentosus (firmicutes) MIC00728
             Description Lactobacillus pentosus KF340 induced a regulatory phenotype which, in turn, induced IFN-gamma producing Tr1 cells from naive CD4+ T cells. [38]
         Lactobacillus reuteri (firmicutes) MIC00731
             Description Lactobacillus reuteri treatment also decreased the serum levels of the inflammatory cytokines KC, TNF-Alpha, IFN-Gamma, and IL-6 in the DSS colitis mice. [39]
         Leptospira borgpetersenii (spirochaetes) MIC00758
             Description The abundance of Leptospira borgpetersenii is associated with IFN-Gamma. [40]
         Leuconostoc mesenteroides (firmicutes) MIC00766
             Description Stimulation with heat-killed Leuconostoc mesenteroides subsp. mesenteroides in mouse splenocytes induced the expression of IFN-Gamma, which was dependent on IL-12 production by Leuconostoc mesenteroides subsp. mesenteroides. [41]
         Listeria monocytogenes (firmicutes) MIC00771
             Description At the species level, Listeria monocytogenes is associated with IFNGamma. [42]
         Methanobrevibacter smithii (euryarchaeotes) MIC00792
             Description The abundance of Methanobrevibacter smithii is associated with IFN-Gamma. [43]
         Mycobacterium leprae (actinobacteria) MIC00851
             Description 9 of 33 Mycobacterium leprae recombinant proteins could induce IFN-Gamma secretion in tuberculoid (TT)/borderline tuberculoid (BT) patients and HHCs by a WBA in a Brazilian population. [44]
         Mycobacterium sp. (actinobacteria) MIC00855
             Description ML1899 conserved in all mycobacterium sp.up-regulated IFN-gamma. [45]
         Mycobacterium tuberculosis (actinobacteria) MIC00857
             Description The importance of IFN-Gamma production by CD4+ cells is particularly relevant at the early stages of Mycobacterium tuberculosis infection. [46]
         Parascardovia denticolens (actinobacteria) MIC00858
             Description The abundance of Mycobacterium ulcerans is associated with IFN-Gamma. [47]
         Mycobacteroides abscessus (actinobacteria) MIC00845
             Description IFN-Gamma is essential against Mycobacterium abscessus in the murine model. [48]
         Mycoplasma genitalium (mycoplasmas) MIC00870
             Description At the class level, Mollicutes is associated with IFN-Gamma. [49]
         Neisseria lactamica (beta-proteobacteria) MIC00888
             Description The Th1 cytokines INF-Gamma and IL-12p70 were also augmented in response to Neisseria lactamica PorB. [50]
         Neisseria meningitidis (beta-proteobacteria) MIC00891
             Description The abundance of Neisseria meningitidis is associated with IFN-Gamma. [51]
         Nocardia farcinica (actinobacteria) MIC00915
             Description Nocardia farcinica could stimulate the expression of IFN-Gamma. [52]
         Pasteurella dagmatis (gamma-proteobacteria) MIC00966
             Description An attenuated Actinobacillus pleuropneumoniae serovar 1 live vaccine prototype stimulated gamma interferon (IFN-) production. [53]
         Peptostreptococcus anaerobius (firmicutes) MIC00980
             Description Peptostreptococcus anaerobius was associated with IFN-gamma. [54]
         Phenylobacterium (alpha-proteobacteria) MIC00985
             Description The abundance of Phenylobacterium is associated with IFN-Gamma. [55]
         Prevotella copri (CFB bacteria) MIC01010
             Description Prevotella copri is associated with IFN-Gamma. [56]
         Rhodobacter capsulatus (alpha-proteobacteria) MIC01089
             Description The abundance of Rhodobacter capsulatus is associated with IFN-Gamma. [57]
         Rickettsia rickettsii (alpha-proteobacteria) MIC01109
             Description Significantly higher levels of IFN-gamma or TNF-alpha secreted by CD4+ T cells from Rickettsia rickettsii-infected mice were detected after immunization with GWP. [58]
         Roseburia faecis (firmicutes) MIC01116
             Description The mRNA expression levels of IL-1Beta, IL-10, IFN-Gamma, and TNF-Alpha negatively correlated (p<0.05) with the abundance of OTU related to Roseburia faecis. [59]
         Streptococcus dysgalactiae (firmicutes) MIC01247
             Description The GapC protein is highly conserved surface dehydrogenase among Streptococcus dysgalactiae (S. dysgalactiae) and is shown to be involved in bacterial virulence. High levels of IFN-Gamma and IL-17A, as well as moderate levels of IL-10 and IL-4 were detected in CD4(+) T-cells isolated from both GapC and peptide-immunized mice in vivo, suggesting that GapC63-77 and GapC96-110 preferentially elicited polarized Th1/Th17-type responses. [60]
         Streptococcus salivarius (firmicutes) MIC01268
             Description Streptococcus salivarius could induce IFN-gamma. [61]
         Streptococcus thermophilus (firmicutes) MIC01272
             Description Streptococcus thermophilus 285 could upregulate IFN-Gamma. [62]
         Subdoligranulum variabile (firmicutes) MIC01286
             Description The abundance of Subdoligranulum variabile is associated with IFN-Gamma. [63]
         Tropheryma whipplei (actinobacteria) MIC01334
             Description Tropheryma whipplei could decrease IFN-Gamma. [64]
         Ureaplasma parvum (mycoplasmas) MIC01359
             Description The abundance of Ureaplasma parvum is associated with IFN-gamma. [65]
         Yersinia pestis (enterobacteria) MIC01401
             Description Specific CD8 T cellmediated protection against pneumonic plague (caused by Yersinia pestis Infection) is dependent on TNFAlpha and IFNGamma, but not on perforin. [66]
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