General Information of MIC (ID: MIC01334)
MIC Name	Tropheryma whipplei (actinobacteria)
MIC Synonyms	Whipple's bacillus
Body Site	Lung
Lineage	Kingdom: Bacteria Phylum: Actinobacteria Class: Actinobacteria Order: Micrococcales Family: Micrococcaceae Genus: Tropheryma Species: Tropheryma whipplei
Oxygen Sensitivity	Aerobe
Microbial Metabolism	Fermentative
Gram	Positive
Host Relationship	Pathogen
Genome Size (bp)	927303
Description	Tropheryma whipplei is a Gram positive, rod shaped bacteria which needs to live in an aerobic environment that is host-associated. It is found in human feces and may cause Whipple disease .
External Links	Taxonomy ID	2039
	Genome Assembly ID	ASM19607v1
	GOLD Organism ID	Go0000631
Disease Relevance
Intestinal malabsorption  [ICD-11: DA96]
Description	Tropheryma whipplei was associated with Whipple's disease.				[1]
Irritable bowel syndrome  [ICD-11: DD91]
Description	Tropheryma whipplei was associated with diarrheal disease.				[2]

Host Immune Factors (HIFs)
Interferon gamma
HIF ID	HIFM0260	HIF Info	Class	Cytokine (Cyt)
Description	Tropheryma whipplei could decrease IFN-Gamma.				[3]
CD8+ T cells
HIF ID	HIFC0073	HIF Info	Class	T cells (TCs)
Description	Tropheryma whipplei could decrease CD8+ T cells responses.				[3]

Environmental Factor(s)
Disbiome ID			428

References
1	Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis. Immunity. 2019 Apr 16;50(4):1099-1114.e10. doi: 10.1016/j.immuni.2019.02.006. Epub 2019 Mar 12.
2	Does Tropheryma whipplei contribute to travelers' diarrhea: A PCR analysis of paired stool samples in French travelers to Senegal. Travel Med Infect Dis. 2014 May-Jun;12(3):264-7. doi: 10.1016/j.tmaid.2014.01.009. Epub 2014 Feb 28.
3	Peripheral T-Cell Reactivity to Heat Shock Protein 70 and Its Cofactor GrpE from Tropheryma whipplei Is Reduced in Patients with Classical Whipple's Disease. Infect Immun. 2017 Jul 19;85(8):e00363-17. doi: 10.1128/IAI.00363-17. Print 2017 Aug.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.