General Information of HIF (ID: HIFC0073)
HIF Name	CD8+ T cells
HIF Synonym(s)	CD8+ T cell, CD8+ T cells
HIF Classification	T cells (TCs)
Description	The CD8 co-receptor is predominantly expressed on the surface of cytotoxic T cells, but can also be found on natural killer cells, cortical thymocytes, and dendritic cells.The CD8 molecule is a marker for cytotoxic T cell population. It is expressed in T cell lymphoblastic lymphoma and hypo-pigmented mycosis fungoides.				[1]

Microbe Species (MIC) Regulated by This HIF
Actinomyces viscosus (actinobacteria)			MIC00038
Description	CD8+ cells may mediate oral tolerance of humoral immunity induced by low doses of Actinomyces viscosus.				[2]
Akkermansia sp. (verrucomicrobia)			MIC00057
Description	A purified membrane protein from Akkermansia muciniphila blunts colitis associated tumourigenesis by modulation of CD8 T cells.				[3]
Barnesiella intestinihominis (CFB bacteria)			MIC00192
Description	Barnesiella intestinihominis induced the proliferation of CD8+ T cells residing in the epithelial layer.				[4]
Chlamydia pneumoniae (chlamydias)			MIC00350
Description	The activation of CD8+ T cells response is critical to resolve Chlamydophila pneumoniae infection.				[5]
Clostridium sp. (firmicutes)			MIC00418
Description	Clostridium is associated with CD8+ T lymphocytes responses.				[6]
Dialister invisus (firmicutes)			MIC00505
Description	Dialister invisus is associated with CD8+ T cells responses.				[7]
Enterococcus hirae (firmicutes)			MIC00551
Description	Reactivity toward Enterococcus hirae demonstrated robust CD8+ T cell response.				[8]
Eubacterium saphenum (firmicutes)			MIC00579
Description	Low intracellular production of IL-4/IFN-gamma in CD8+ T cells was induced after injection of Eubacterium saphenum.				[9]
Fusobacterium nucleatum (fusobacteria)			MIC00617
Description	High levels of infiltrating CD8+ cells have been associated with better patient prognosis in colorectal cancer with Fusobacterium nucleatum infection.				[10]
Glaesserella parasuis (gamma-proteobacteria)			MIC00654
Description	CD8+T cells were significantly increased after challenge with Haemophilus parasuis.				[11]
Haemophilus ducreyi (gamma-proteobacteria)			MIC00650
Description	Haemophilus ducreyi induced CD8 T cell infiltrate in the upper and midreticular dermis of papules.				[12]
Human immunodeficiency virus 1 (viruses)			MIC02009
Description	CD8+ T cell responses was controlled by Treg cells against HIV.				[13]
Lactobacillus johnsonii (firmicutes)			MIC00721
Description	Lactobacillus johnsonii recolonization resulted in the high CD8+ cell numbers in the small intestine and spleen.				[14]
Listeria monocytogenes (firmicutes)			MIC00771
Description	A specific CD8 T cell response was developed by the host cell in response to cytosolic Listeria monocytogenes, which is crucial for the control of infection.				[15]
Myxococcus xanthus (delta-proteobacteria)			MIC00880
Description	Suppression of the delayed-type hypersensitivit response after myxospore of Myxococcus xanthus inoculation may be attributable to T-suppressor cells stimulation.				[16]
Neisseria gonorrhoeae (beta-proteobacteria)			MIC00885
Description	Greater CD8+ T cell responses was elicited by oral immunization with the ghost vaccine candidate than Neisseria gonorrhoeae DNA vaccine alone.				[17]
Parabacteroides distasonis (CFB bacteria)			MIC00949
Description	Consistent with an overall anti-inflammatory status, the abundance of Parabacteroides increased when decreases in CD8+ T cells.				[18]
Rikenella microfusus (CFB bacteria)			MIC01112
Description	Rikenellaceae is associated with CD8+ T cells responses.				[19]
Roseburia sp. (firmicutes)			MIC01115
Description	Roseburia was associated with CD80+ T cells responses.				[20]
Streptococcus salivarius (firmicutes)			MIC01268
Description	Streptococcus salivarius-mediated CD8 T cell stimulation required antigen presentation by macrophages in oral squamous cell carcinoma.				[21]
Tropheryma whipplei (actinobacteria)			MIC01334
Description	Tropheryma whipplei could decrease CD8+ T cells responses.				[22]
Turicibacter (firmicutes)			MIC01339
Description	Turicibacter species can modulate CD8+ T cells responses.				[23]
Unidentified retrovirus (viruses)			MIC02003
Description	CD8+ T cells proliferation was suppressed by Tregs during the late phase of acute Friend retrovirus infection.				[13]
Vibrio vulnificus (gamma-proteobacteria)			MIC01378
Description	Vibrio vulnificus was associated with CD8+ T cell responses.				[24]
Yersinia pestis (enterobacteria)			MIC01401
Description	YopE of Yersinia pestis was found to contain a dominant CD8 T cell epitope, which can be recognized by nearly 20 % of pulmonary CD8 T cells.				[25]
Yersinia pseudotuberculosis (enterobacteria)			MIC01402
Description	Yersinia pseudotuberculosis is associated with CD8+ T cells responses.				[26]

References
1	CD8(+) T cell exhaustion.Semin Immunopathol. 2019 May;41(3):327-337. doi: 10.1007/s00281-019-00744-5. Epub 2019 Apr 15.
2	Role of CD4 and CD8 T-cells in the induction of oral tolerance to Actinomyces viscosus in mice. Oral Microbiol Immunol. 2006 Jun;21(3):151-8. doi: 10.1111/j.1399-302X.2006.00263.x.
3	A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8(+) T cells in mice. Gut. 2020 Mar 13:gutjnl-2019-320105. doi: 10.1136/gutjnl-2019-320105. Online ahead of print.
4	Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects. Immunity. 2016 Oct 18;45(4):931-943. doi: 10.1016/j.immuni.2016.09.009. Epub 2016 Oct 4.
5	Chlamydia pneumoniae Infection and Inflammatory Diseases. For Immunopathol Dis Therap. 2016;7(3-4):237-254. doi: 10.1615/ForumImmunDisTher.2017020161.
6	Dysbiosis gut microbiota associated with inflammation and impaired mucosal immune function in intestine of humans with non-alcoholic fatty liver disease. Sci Rep. 2015 Feb 3;5:8096. doi: 10.1038/srep08096.
7	Gut microbiome in type 1 diabetes: A comprehensive review. Diabetes Metab Res Rev. 2018 Oct;34(7):e3043. doi: 10.1002/dmrr.3043. Epub 2018 Jul 17.
8	Reactivity toward Bifidobacterium longum and Enterococcus hirae demonstrate robust CD8(+) T cell response and better prognosis in HBV-related hepatocellular carcinoma. Exp Cell Res. 2017 Sep 15;358(2):352-359. doi: 10.1016/j.yexcr.2017.07.009. Epub 2017 Jul 8.
9	Intraperitoneal immune cell responses to Eubacterium saphenum in mice. Microbiol Immunol. 2001;45(1):29-37. doi: 10.1111/j.1348-0421.2001.tb01271.x.
10	Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer. World J Gastroenterol. 2016 Jan 14;22(2):557-66. doi: 10.3748/wjg.v22.i2.557.
11	Haemophilus parasuis: infection, immunity and enrofloxacin. Vet Res. 2015 Oct 28;46:128. doi: 10.1186/s13567-015-0263-3.
12	The immune response to Haemophilus ducreyi resembles a delayed-type hypersensitivity reaction throughout experimental infection of human subjects. J Infect Dis. 1998 Dec;178(6):1688-97. doi: 10.1086/314489.
13	Regulatory T cells in retroviral infections.PLoS Pathog. 2018 Feb 15;14(2):e1006776. doi: 10.1371/journal.ppat.1006776. eCollection 2018 Feb.
14	Fecal Microbiota Transplantation, Commensal Escherichia coli and Lactobacillus johnsonii Strains Differentially Restore Intestinal and Systemic Adaptive Immune Cell Populations Following Broad-spectrum Antibiotic Treatment. Front Microbiol. 2017 Dec 11;8:2430. doi: 10.3389/fmicb.2017.02430. eCollection 2017.
15	HDAC6 controls innate immune and autophagy responses to TLR-mediated signalling by the intracellular bacteria Listeria monocytogenes. PLoS Pathog. 2017 Dec 27;13(12):e1006799. doi: 10.1371/journal.ppat.1006799. eCollection 2017 Dec.
16	Immunomodulation by myxospores of Myxococcus xanthus.J Gen Microbiol. 1985 Aug;131(8):2035-9. doi: 10.1099/00221287-131-8-2035.
17	Design and immune characterization of a novel Neisseria gonorrhoeae DNA vaccine using bacterial ghosts as vector and adjuvant. Vaccine. 2018 Jul 16;36(30):4532-4539. doi: 10.1016/j.vaccine.2018.06.006. Epub 2018 Jun 18.
18	Chronic oral exposure to glycated whey proteins increases survival of aged male NOD mice with autoimmune prostatitis by regulating the gut microbiome and anti-inflammatory responses. Food Funct. 2020 Jan 29;11(1):153-162. doi: 10.1039/c9fo01740b.
19	Gut Microbiome, Short-Chain Fatty Acids, and Mucosa Injury in Young Adults with Human Immunodeficiency Virus Infection. Dig Dis Sci. 2019 Jul;64(7):1830-1843. doi: 10.1007/s10620-018-5428-2. Epub 2018 Dec 17.
20	Microbiota Induced Changes in the Immune Response in Pregnant Mice. Front Immunol. 2020 Jan 9;10:2976. doi: 10.3389/fimmu.2019.02976. eCollection 2019.
21	Streptococcus salivarius-mediated CD8(+) T cell stimulation required antigen presentation by macrophages in oral squamous cell carcinoma. Exp Cell Res. 2018 May 15;366(2):121-126. doi: 10.1016/j.yexcr.2018.03.007. Epub 2018 Mar 9.
22	Peripheral T-Cell Reactivity to Heat Shock Protein 70 and Its Cofactor GrpE from Tropheryma whipplei Is Reduced in Patients with Classical Whipple's Disease. Infect Immun. 2017 Jul 19;85(8):e00363-17. doi: 10.1128/IAI.00363-17. Print 2017 Aug.
23	Protein Malnutrition Alters Tryptophan and Angiotensin-Converting Enzyme 2 Homeostasis and Adaptive Immune Responses in Human Rotavirus-Infected Gnotobiotic Pigs with Human Infant Fecal Microbiota Transplant.Clin Vaccine Immunol. 2017 Aug 4;24(8):e00172-17. doi: 10.1128/CVI.00172-17. Print 2017 Aug.
24	Immunoinformatics design of a novel multi-epitope peptide vaccine to combat multi-drug resistant infections caused by Vibrio vulnificus. Eur J Pharm Sci. 2020 Jan 15;142:105160. doi: 10.1016/j.ejps.2019.105160. Epub 2019 Nov 18.
25	Immunology of Yersinia pestis Infection. Adv Exp Med Biol. 2016;918:273-292. doi: 10.1007/978-94-024-0890-4_10.
26	CCR2(+) Inflammatory Monocytes Are Recruited to Yersinia pseudotuberculosis Pyogranulomas and Dictate Adaptive Responses at the Expense of Innate Immunity during Oral Infection. Infect Immun. 2018 Feb 20;86(3):e00782-17. doi: 10.1128/IAI.00782-17. Print 2018 Mar.

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