Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00650)
MIC Name Haemophilus ducreyi (gamma-proteobacteria)
MIC Synonyms Coccobacillus ducreyi
Body Site Skin
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Pasteurellales
Family: Pasteurellaceae
Genus: Haemophilus
Species: Haemophilus ducreyi
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Nonfermentative
Gram Negative
Host Relationship Pathogen
Genome Size (bp) 1631557
Description Haemophilus ducreyi is a Gram-negative, rod-shaped, facultatively anaerobic, non-motile, pathogenic bacillus. Unlike other Haemophila, H. ducreyi is unable to synthesize heme because it lacks the enzyme ferro-chelatase, which is used to catalyze the synthesis of heme by inserting ferrous iron into protoporphyrin IX.
External Links Taxonomy ID
730
Genome Assembly ID
ASM794v1
GOLD Organism ID
Go0502031
Disease Relevance
          Chancroid  [ICD-11: 1A90]
             Description Haemophilus ducreyi causes the genital ulcer disease chancroid in adults. [1]
Host Immune Factors (HIFs)
          C-C motif chemokine 27
             HIF ID HIFM0029 HIF Info       Class Antimicrobial peptide (AMP)
             Description CCL27 staining was uniformly positive throughout infected and uninfected sections and appeared unchanged in response to Haemophilus ducreyi infection in the skin. [2]
          Interferon-2
             HIF ID HIFM0141 HIF Info       Class Cytokine (Cyt)
             Description Haemophilus ducreyi stimulated secretion of IL-2 by keratinocytes. [3]
          C-X-C motif chemokine 8
             HIF ID HIFM0153 HIF Info       Class Cytokine (Cyt)
             Description Haemophilus ducreyi stimulated secretion of IL-8 by keratinocytes. [3]
          Interferon gamma
             HIF ID HIFM0260 HIF Info       Class Cytokine (Cyt)
             Description The abundance of Haemophilus ducreyi is associated with IFN-Gamma. [3]
          Dendritic cells
             HIF ID HIFC0003 HIF Info       Class Dendritic cells (DCs)
             Description The number of Langerhanscells(a kind of dendritic cells) increased during Haemophilus ducreyi infection. [3]
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description The abundance of Haemophilus ducreyi is associated with IgG immune response. [3]
          CD4+ regulatory T cells
             HIF ID HIFC0034 HIF Info       Class T cells (TCs)
             Description Haemophilus ducreyi induced CD4 T cell infiltrate in the upper and midreticular dermis of papules. [3]
          CD19+ T cells
             HIF ID HIFC0060 HIF Info       Class T cells (TCs)
             Description Haemophilus ducreyi induced a small amount of CD19+ T cells production. [3]
          CD3+ T cells
             HIF ID HIFC0064 HIF Info       Class T cells (TCs)
             Description Haemophilus ducreyi induced CD3 T cell infiltrate in the upper and midreticular dermis of papules. [3]
          CD4+ helper T cells
             HIF ID HIFC0068 HIF Info       Class T cells (TCs)
             Description Haemophilus ducreyi induced Th1 cells to secrete interleukin-2. [3]
          CD4+ T cells
             HIF ID HIFC0069 HIF Info       Class T cells (TCs)
             Description CD4 cells were recruited to the skin at the pustular stage of disease with Haemophilus ducreyi infection. [3]
          CD8+ T cells
             HIF ID HIFC0073 HIF Info       Class T cells (TCs)
             Description Haemophilus ducreyi induced CD8 T cell infiltrate in the upper and midreticular dermis of papules. [3]
Environmental Factor(s)
             Disbiome ID
      247
             gutMDisorder ID
      gm0357
References
1 Determination of an Interaction Network between an Extracellular Bacterial Pathogen and the Human Host. mBio. 2019 Jun 18;10(3):e01193-19. doi: 10.1128/mBio.01193-19.
2 Trafficking pathways and characterization of CD4 and CD8 cells recruited to the skin of humans experimentally infected with Haemophilus ducreyi.Infect Immun. 2005 Jul;73(7):3896-902. doi: 10.1128/IAI.73.7.3896-3902.2005.
3 The immune response to Haemophilus ducreyi resembles a delayed-type hypersensitivity reaction throughout experimental infection of human subjects. J Infect Dis. 1998 Dec;178(6):1688-97. doi: 10.1086/314489.

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