Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFC0034)
HIF Name
CD4+ regulatory T cells
HIF Synonym(s)
CD4 regulatory T cells, CD4+ Tregulatory cells
HIF Classification
T cells (TCs)
Description The CD4+T cells carry out multiple functions, ranging from activation of the cells of the innate immune system, B-lymphocytes, cytotoxic T cells, as well as nonimmune cells, and also play critical role in the suppression of immune reaction. [1]
Microbe Species (MIC) Regulated by This HIF
         Achromobacter xylosoxidans (beta-proteobacteria) MIC00007
             Description The compartmentalization of Achromobacter xylosoxidans was dependent on the innate lymphoid cells at the gut-immune interface, whose function was associated with CD4 regulatory T cells. [2]
         Actinobacteria (actinobacteria) MIC00025
             Description The relative abundance of Bacteroidetes was strong positively associated with CD4+ Tregulatory cells. [3]
         Actinomyces viscosus (actinobacteria) MIC00038
             Description CD4+ cells may mediate oral tolerance of cellular immunity induced by low doses of Actinomyces viscosus. [4]
         Bacteroides fragilis (CFB bacteria) MIC00158
             Description Bacteroides fragilis is associated with CD4+ T cells responses. [5]
         Bacteroidetes (CFB bacteria) MIC00141
             Description The relative abundance of Bacteroidetes was negatively associated with CD4+ Tregulatory cells. [3]
         Bifidobacterium breve (actinobacteria) MIC00210
             Description Bifidobacterium breve M-16V+ LRG significantly increased the Treg proportion in large intestinal LPL CD4+ cells. [6]
         Blautia obeum (firmicutes) MIC00240
             Description Blautia obeum is associated with CD4+T cells responses. [7]
         Brucella canis (alpha-proteobacteria) MIC00269
             Description Brucella canis induces CD4+ T cells to produce multi-cytokine Th1/Th17 via dendritic cell activation. [8]
         Candida albicans (budding yeasts) MIC00317
             Description The gut CD4+ T cells were enriched in reactivity toward intestinal bacteria and Candida albicans(p<0.001). [7]
         Chlamydia pneumoniae (chlamydias) MIC00350
             Description The activation of CD4+ T cells response is critical to resolve Chlamydophila pneumoniae infection. [9]
         Clostridium butyricum (firmicutes) MIC00388
             Description Clostridium butyricum CGMCC0313.1 is associated with CD4+ T cells responses. [10]
         Clostridium sp. (firmicutes) MIC00418
             Description Clostridium spp.induced CD4+ regulatory T cells in the intestine and ameliorated intestinal inflammation in a murine model of IBD. [11]
         Coprococcus comes (firmicutes) MIC00442
             Description Relative abundance of Coprococcus comes was associated with CD4+ T-cell counts. [12]
         Corynebacterium diphtheriae (actinobacteria) MIC00452
             Description Corynebacterium diphtheriae was associated with CD4+T cells responses. [13]
         Eubacterium rectale (firmicutes) MIC00578
             Description Eubacterium rectale is associated with CD4+ T-cells responses. [14]
         Eubacterium saphenum (firmicutes) MIC00579
             Description Low intracellular production of IL-4/IFN-gamma in CD4+ T cells was induced after injection of Eubacterium saphenum. [15]
         Faecalibacterium prausnitzii (firmicutes) MIC00590
             Description Relative abundance of Faecalibacterium prausnitzii was associated with CD4+ T-cell counts. [12]
         Haemophilus ducreyi (gamma-proteobacteria) MIC00650
             Description Haemophilus ducreyi induced CD4 T cell infiltrate in the upper and midreticular dermis of papules. [16]
         Lactobacillus acidophilus (firmicutes) MIC00702
             Description A subset of CD4+ T cells reactive to Lactobacillus acidophilus could increase the production of the immunoregulatory cytokine IL10 of 7%(p<0.05). [7]
         Lactobacillus johnsonii (firmicutes) MIC00721
             Description Lactobacillus johnsonii recolonization resulted in the high CD4+ cell numbers in the small intestine and spleen. [17]
         Mycobacterium tuberculosis (actinobacteria) MIC00857
             Description A subset of CD4+ T cells reactive to Mycobacterium tuberculosis could increase the production of the immunoregulatory cytokine IL10 of 7%(p<0.05). [7]
         Neisseria gonorrhoeae (beta-proteobacteria) MIC00885
             Description Greater CD4+ T cell responses was elicited by oral immunization with the ghost vaccine candidate than Neisseria gonorrhoeae DNA vaccine alone. [18]
         Parabacteroides distasonis (CFB bacteria) MIC00949
             Description Consistent with an overall anti-inflammatory status, the abundance of Parabacteroides increased when decreases in CD4+ T cells. [19]
         Rickettsia rickettsii (alpha-proteobacteria) MIC01109
             Description CD4+ T cells secreted significantly higher levels of IFN-gamma or TNF-alpha during Rickettsia rickettsii infection. [20]
         Rikenella microfusus (CFB bacteria) MIC01112
             Description Rikenellaceae is associated with CD4+ T cells responses. [21]
         Roseburia sp. (firmicutes) MIC01115
             Description Roseburia could induce CD4+ cells responses. [22]
         Staphylococcus aureus (firmicutes) MIC01208
             Description The microbiota-specific memory CD4+ T cells with 60%expansion after stimulation with Staphylococcus aureus(P 0.0001). [7]
         Staphylococcus xylosus (firmicutes) MIC01227
             Description Staphylococcus xylosus could increase CD4+ T cells responses. [23]
         Streptococcus dysgalactiae (firmicutes) MIC01247
             Description Immunizationof GapC protein can induce specific CD4(+) T-cell immune responses and protect against Streptococcus dysgalactiae infection. [24]
         Streptococcus pneumoniae (firmicutes) MIC01263
             Description CD4+ T cells mediated humoral immune responses to type 3 capsular polysaccharide of Streptococcus pneumoniae. [25]
         Subdoligranulum variabile (firmicutes) MIC01286
             Description Relative abundance of Subdoligranulum was associated with CD4+ T-cell counts. [12]
         Yersinia pseudotuberculosis (enterobacteria) MIC01402
             Description CD4+ T cell numbers was reduced in the absence of CCR2 during Yersinia pseudotuberculosis infection. [26]
References
1 CD4+T cells: differentiation and functions. Clin Dev Immunol. 2012;2012:925135. doi: 10.1155/2012/925135. Epub 2012 Mar 14.
2 Antibody response to Achromobacter xylosoxidans during HIV infection is associated with lower CD4 levels and increased lymphocyte activation. Clin Vaccine Immunol. 2014 Jan;21(1):46-50. doi: 10.1128/CVI.00553-13. Epub 2013 Oct 30.
3 Associations between the gut microbiota and host immune markers in pediatric multiple sclerosis and controls.BMC Neurol. 2016 Sep 21;16(1):182. doi: 10.1186/s12883-016-0703-3.
4 Role of CD4 and CD8 T-cells in the induction of oral tolerance to Actinomyces viscosus in mice. Oral Microbiol Immunol. 2006 Jun;21(3):151-8. doi: 10.1111/j.1399-302X.2006.00263.x.
5 Interactions between the microbiota, immune and nervous systems in health and disease. Nat Neurosci. 2017 Feb;20(2):145-155. doi: 10.1038/nn.4476. Epub 2017 Jan 16.
6 The Combination of Bifidobacterium breve and Three Prebiotic Oligosaccharides Modifies Gut Immune and Endocrine Functions in Neonatal Mice. J Nutr. 2019 Feb 1;149(2):344-353. doi: 10.1093/jn/nxy248.
7 Circulating and Tissue-Resident CD4(+) T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation. Gastroenterology. 2017 Nov;153(5):1320-1337.e16. doi: 10.1053/j.gastro.2017.07.047. Epub 2017 Aug 4.
8 Brucella canis induces canine CD4(+) T cells multi-cytokine Th1/Th17 production via dendritic cell activation. Comp Immunol Microbiol Infect Dis. 2019 Feb;62:68-75. doi: 10.1016/j.cimid.2018.11.017. Epub 2018 Nov 30.
9 Chlamydia pneumoniae Infection and Inflammatory Diseases. For Immunopathol Dis Therap. 2016;7(3-4):237-254. doi: 10.1615/ForumImmunDisTher.2017020161.
10 Clostridium butyricum CGMCC0313.1 Protects against Autoimmune Diabetes by Modulating Intestinal Immune Homeostasis and Inducing Pancreatic Regulatory T Cells. Front Immunol. 2017 Oct 19;8:1345. doi: 10.3389/fimmu.2017.01345. eCollection 2017.
11 Commensal bacteria calibrate the activation threshold of innate antiviral immunity.Immunity. 2012 Jul 27;37(1):158-70. doi: 10.1016/j.immuni.2012.04.011. Epub 2012 Jun 14.
12 Association Between Gut Microbiota and CD4 Recovery in HIV-1 Infected Patients. Front Microbiol. 2018 Jul 2;9:1451. doi: 10.3389/fmicb.2018.01451. eCollection 2018.
13 Bacterial flagellin and diphtheria toxin co-stimulate IL-17-producing thymocytes. Cytokine. 2013 Oct;64(1):221-6. doi: 10.1016/j.cyto.2013.06.318. Epub 2013 Aug 8.
14 Specific prebiotics modulate gut microbiota and immune activation in HAART-naive HIV-infected adults: results of the "COPA" pilot randomized trial. Mucosal Immunol. 2011 Sep;4(5):554-63. doi: 10.1038/mi.2011.15. Epub 2011 Apr 27.
15 Intraperitoneal immune cell responses to Eubacterium saphenum in mice. Microbiol Immunol. 2001;45(1):29-37. doi: 10.1111/j.1348-0421.2001.tb01271.x.
16 The immune response to Haemophilus ducreyi resembles a delayed-type hypersensitivity reaction throughout experimental infection of human subjects. J Infect Dis. 1998 Dec;178(6):1688-97. doi: 10.1086/314489.
17 Fecal Microbiota Transplantation, Commensal Escherichia coli and Lactobacillus johnsonii Strains Differentially Restore Intestinal and Systemic Adaptive Immune Cell Populations Following Broad-spectrum Antibiotic Treatment. Front Microbiol. 2017 Dec 11;8:2430. doi: 10.3389/fmicb.2017.02430. eCollection 2017.
18 Design and immune characterization of a novel Neisseria gonorrhoeae DNA vaccine using bacterial ghosts as vector and adjuvant. Vaccine. 2018 Jul 16;36(30):4532-4539. doi: 10.1016/j.vaccine.2018.06.006. Epub 2018 Jun 18.
19 Chronic oral exposure to glycated whey proteins increases survival of aged male NOD mice with autoimmune prostatitis by regulating the gut microbiome and anti-inflammatory responses. Food Funct. 2020 Jan 29;11(1):153-162. doi: 10.1039/c9fo01740b.
20 Th1 epitope peptides induce protective immunity against Rickettsia rickettsii infection in C3H/HeN mice. Vaccine. 2017 Dec 18;35(51):7204-7212. doi: 10.1016/j.vaccine.2017.09.068. Epub 2017 Oct 10.
21 Gut Microbiome, Short-Chain Fatty Acids, and Mucosa Injury in Young Adults with Human Immunodeficiency Virus Infection. Dig Dis Sci. 2019 Jul;64(7):1830-1843. doi: 10.1007/s10620-018-5428-2. Epub 2018 Dec 17.
22 Microbiota Induced Changes in the Immune Response in Pregnant Mice. Front Immunol. 2020 Jan 9;10:2976. doi: 10.3389/fimmu.2019.02976. eCollection 2019.
23 The resident pathobiont Staphylococcus xylosus in Nfkbiz-deficient skin accelerates spontaneous skin inflammation. Sci Rep. 2017 Jul 24;7(1):6348. doi: 10.1038/s41598-017-05740-z.
24 Identification and characterization of CD4+ T-cell epitopes on GapC protein of Streptococcus dysgalactiae. Microb Pathog. 2016 Feb;91:46-53. doi: 10.1016/j.micpath.2015.11.025. Epub 2015 Nov 30.
25 T Cell-Mediated Humoral Immune Responses to Type 3 Capsular Polysaccharide of Streptococcus pneumoniae. J Immunol. 2017 Jul 15;199(2):598-603. doi: 10.4049/jimmunol.1700026. Epub 2017 May 31.
26 CCR2(+) Inflammatory Monocytes Are Recruited to Yersinia pseudotuberculosis Pyogranulomas and Dictate Adaptive Responses at the Expense of Innate Immunity during Oral Infection. Infect Immun. 2018 Feb 20;86(3):e00782-17. doi: 10.1128/IAI.00782-17. Print 2018 Mar.

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