Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00721)
MIC Name Lactobacillus johnsonii (firmicutes)
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus johnsonii
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Respiratory or Fermentative
Gram Positive
Host Relationship Probiotic
Genome Size (bp) 1992676
No. of Coding Genes 1871
No. of Non-Coding Genes 52
No. of Small Non-Coding Genes 52
No. of Gene Transcripts 2001
No. of Pseudogenes 78
No. of Base Pairs 2064674
Description Lactobacillus johnsonii is a facultative anaerobic, Gram-positive species in the genus Lactobacillus. It is has been identified as having probiotic properties.
External Links Taxonomy ID
33959
Genome Assembly ID
ASM157266v1
GOLD Organism ID
Go0009297
Disease Relevance
          Type 1 diabetes mellitus  [ICD-11: 5A10]
             Description Lactobacillus johnsonii was potential agents of influence in type 1 diabetes development. [1]
          Vaginitis  [ICD-11: GA02]
             Description Lactobacillus johnsonii was associated with bacterial vaginosis. [2]
Host Genetic Factors (HGFs)
          hsa-miR-375-3p
             HGF ID HGF0674 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of hsa-miR-375-3p was affected by Lactobacillus johnsonii. [3]
          hsa-miR-1224-5p
             HGF ID HGF0634 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of hsa-miR-1224-5p was decreased with the absence of Lactobacillus johnsonii. [3]
          hsa-let-7b-5p
             HGF ID HGF0300 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of hsa-let-7b-5p was decreased with the absence of Lactobacillus johnsonii. [3]
          hsa-miR-141-3p
             HGF ID HGF0259 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of hsa-miR-141-3p was decreased with the absence of Lactobacillus johnsonii. [3]
          hsa-miR-18a-5p
             HGF ID HGF0238 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-18a expression can be downregulated by Fusobacterium nucleatum. [3]
          hsa-miR-200a-3p
             HGF ID HGF0213 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of hsa-miR-200a-3p was decreased with the absence of Lactobacillus johnsonii. [3]
          hsa-miR-21-5p
             HGF ID HGF0204 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-21-5p expresssion showed significant upregulation in Lactobacillus johnsonii 129 (p-value<0.05). [3]
Host Immune Factors (HIFs)
          Interferon-10
             HIF ID HIFM0128 HIF Info       Class Cytokine (Cyt)
             Description Lactobacillus johnsonii recolonization could maintain colonic IL-10 production. [4]
          CD4+ regulatory T cells
             HIF ID HIFC0034 HIF Info       Class T cells (TCs)
             Description Lactobacillus johnsonii recolonization resulted in the high CD4+ cell numbers in the small intestine and spleen. [4]
          CD8+ T cells
             HIF ID HIFC0073 HIF Info       Class T cells (TCs)
             Description Lactobacillus johnsonii recolonization resulted in the high CD8+ cell numbers in the small intestine and spleen. [4]
Environmental Factor(s)
             Disbiome ID
      1309
             gutMDisorder ID
      gm0393
References
1 Lactobacillus johnsonii N6.2 mitigates the development of type 1 diabetes in BB-DP rats. PLoS One. 2010 May 6;5(5):e10507. doi: 10.1371/journal.pone.0010507.
2 Characterization of culturable vaginal Lactobacillus species among women with and without bacterial vaginosis from the United States and India: a cross-sectional study. J Med Microbiol. 2014 Jul;63(Pt 7):931-935. doi: 10.1099/jmm.0.073080-0. Epub 2014 May 16.
3 Impact of the gut microbiome on the genome and epigenome of colon epithelial cells: contributions to colorectal cancer development. Genome Med. 2019 Feb 25;11(1):11. doi: 10.1186/s13073-019-0621-2.
4 Fecal Microbiota Transplantation, Commensal Escherichia coli and Lactobacillus johnsonii Strains Differentially Restore Intestinal and Systemic Adaptive Immune Cell Populations Following Broad-spectrum Antibiotic Treatment. Front Microbiol. 2017 Dec 11;8:2430. doi: 10.3389/fmicb.2017.02430. eCollection 2017.

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