General Information of HGF (ID: HGF0204)
HGF Name	hsa-miR-21-5p
HGF Synonym(s)	microRNA 21-5p, MIRN21-5p, MIR21-5p
Source	Homo sapiens
HGF Classification	Non-coding RNA: Micro (ncRNA-miRNA)
Gene Location	chr17
Gene Start Site	59841273	Gene End Site		59841294
Strand	Forward (+)
Sequence	Click here to download the HGF sequence in FASTA format
External Links
	miRBase ID	MIMAT0000076

Microbe Species (MIC) Regulated by This HGF
Bacteroides acidifaciens (CFB bacteria)			MIC00145
Description	Bacteroides acidifaciens type A43 resulted in an upregulation of miR-21-5p.				[1]
Citrobacter rodentium (enterobacteria)			MIC00366
Description	The expression of miR-21 was significantly up-regulated upon infection by Citrobacter rodentium pathogensa (p-value<0.05).				[2]
Escherichia coli (enterobacteria)			MIC00516
Description	The expression of miR-21-5p was significantly up-regulated 1.05-fold change in Escherichia coli.				[3]
Helicobacter pylori (epsilon-proteobacteria)			MIC00669
Description	The expression of miR-21 was significantly up-regulated in Helicobacter pylori infection (p-value<0.05).				[4]
Lactobacillus johnsonii (firmicutes)			MIC00721
Description	The level of miR-21-5p expresssion showed significant upregulation in Lactobacillus johnsonii 129 (p-value<0.05).				[1]
Mycobacterium leprae (actinobacteria)			MIC00851
Description	Infection of monocytes with Mycobacterium leprae triggered an upregulation of hsa-mir-21 in a dose-dependent and time-responsive manner, with a 4.1-fold change.				[5]
Mycobacteroides abscessus (actinobacteria)			MIC00845
Description	The level of miR-21 expression was induced by Mycobacterium species, leading to excessive immune responses.				[6]
Proteobacteria (proteobacteria)			MIC01037
Description	The miR-21 was significantly associated with the abundance of Proteobacteria (p-value<0.05).				[7]
Salmonella enterica subsp. enterica (enterobacteria)			MIC01154
Description	The miR-21-5p presents in mesenteric lymph nodes in Salmonella Typhimurium infected pigs.				[8]
Salmonella sp. (enterobacteria)			MIC01149
Description	hsa-miR-21 miRNA that strongly increase the relative abundance of Salmonella by at least 1.5-fold. The average percentage of Salmonella infection cells(fold over control) is equal to 1.9010.				[9]

References
1	Impact of the gut microbiome on the genome and epigenome of colon epithelial cells: contributions to colorectal cancer development. Genome Med. 2019 Feb 25;11(1):11. doi: 10.1186/s13073-019-0621-2.
2	Multifaceted Roles of microRNAs in Host-Bacterial Pathogen Interaction. Microbiol Spectr. 2019 May;7(3). doi: 10.1128/microbiolspec.BAI-0002-2019.
3	Chronic inflammation with Helicobacter pylori infection is implicated in CD44 overexpression through miR-328 suppression in the gastric mucosa. Ishimoto T, Izumi D, Watanabe M, Yoshida N, Hidaka K, Miyake K, Sugihara H, Sawayama H, Imamura Y, Iwatsuki M, Iwagami S, Baba Y, Horlad H, Komohara Y, Takeya M, Baba H.. J Gastroenterol. 2015 Jul;50(7):751-7. doi: 10.1007/s00535-014-1019-y. Epub 2014 Dec 6.
4	Mechanisms of Inflammasome Signaling, microRNA Induction and Resolution of Inflammation by Helicobacter pylori. Curr Top Microbiol Immunol. 2019;421:267-302. doi: 10.1007/978-3-030-15138-6_11.
5	MicroRNA-21 targets the vitamin D-dependent antimicrobial pathway in leprosy. Nat Med. 2012 Jan 29;18(2):267-73. doi: 10.1038/nm.2584.
6	Commensal microbiota-induced microRNA modulates intestinal epithelial permeability through the small GTPase ARF4. J Biol Chem. 2017 Sep 15;292(37):15426-15433. doi: 10.1074/jbc.M117.788596. Epub 2017 Jul 31.
7	Associations between hepatic miRNA expression, liver triacylglycerols and gut microbiota during metabolic adaptation to high-fat diet in mice. Diabetologia. 2017 Apr;60(4):690-700. doi: 10.1007/s00125-017-4209-3. Epub 2017 Jan 19.
8	Regulatory role of microRNA in mesenteric lymph nodes after Salmonella Typhimurium infection. Vet Res. 2018 Feb 1;49(1):9. doi: 10.1186/s13567-018-0506-1.
9	Effects of Lactobacillus acidophilus and Bifidobacterium bifidum Probiotics on the Expression of MicroRNAs 135b, 26b, 18a and 155, and Their Involving Genes in Mice Colon Cancer. Heydari Z, Rahaie M, Alizadeh AM, Agah S, Khalighfard S, Bahmani S.. Probiotics Antimicrob Proteins. 2019 Dec;11(4):1155-1162. doi: 10.1007/s12602-018-9478-8.

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