Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00669)
MIC Name Helicobacter pylori (epsilon-proteobacteria)
MIC Synonyms Campylobacter pylori subsp. pylori
Body Site Blood
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Epsilonproteobacteria
Order: Campylobacterales
Family: Helicobacteraceae
Genus: Helicobacter
Species: Helicobacter pylori
Oxygen Sensitivity Microaerophile
Microbial Metabolism Strictly respiratory; Glucose is oxidzed but no other sugar is used
Gram Negative
Host Relationship Opportunistic pathogen
Genome Size (bp) 1667867
No. of Coding Genes 1695
No. of Non-Coding Genes 35
No. of Small Non-Coding Genes 35
No. of Gene Transcripts 1730
No. of Base Pairs 1617653
Description Helicobacter pylori, previously known as Campylobacter pylori, is a Gram-negative, helically-shaped, microaerophilic bacterium usually found in the stomach. Helicobacter pylori has been associated with the mucosa-associated lymphoid tissue in the stomach, esophagus, colon, rectum, or tissues around the eye.
External Links Taxonomy ID
210
Genome Assembly ID
ASM25882v1
GOLD Organism ID
Go0455605
Disease Relevance
          Chronic gastric infection  [ICD-11: 1A40]
             Description Gastritis was associated with Helicobacter pylori infection. [1]
          Crohn disease  [ICD-11: DD70]
             Description No specific association with colon disease was found in patients with Helicobacter pylori. [2]
          Gastric cancer  [ICD-11: 2B72]
             Description Helicobacter pylori induced a chronic inflammatory response with the risk of gastric cancer. [3]
          Gastric mucosal injury  [ICD-11: 1A40]
             Description Helicobacter pylori induced gastric mucosal injury. [4]
          Gastric ulcer  [ICD-11: DA60]
             Description Helicobacter pylori (H. pylori) infection underlies gastric ulcer disease, gastric cancer and duodenal ulcer disease. [5]
          Parkinsonism  [ICD-11: 8A00]
             Description The eradication of Helicobacter pylori may influence levodopa pharmacokinetics and improve the motor function of infected patients with Parkinson disease. [6]
          Peptic ulcer  [ICD-11: DA61]
             Description Peptic ulcer was associated with Helicobacter pylori infection. [3]
          Ulcerative colitis  [ICD-11: DD71]
             Description Helicobacter pylori is downregulated in expression of ulcerative colitis disease. [7]
Host Genetic Factors (HGFs)
          hsa-miR-143-3p
             HGF ID HGF0258 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-143-3p expression showed significantly upregulated upon Helicobacter pylori infection (p-value<0.05). [8]
          hsa-miR-124a-1
             HGF ID HGF0707 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-124a expression showed significant downregulation with Helicobacter pylori eradication (p-value<0.05). [9]
          hsa-miR-4496
             HGF ID HGF0681 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-4496 expression attenuate Helicobacter pylori cytotoxin-associated gene A (CagA)-induced cancer-initiating potential. [10]
          hsa-miR-4459
             HGF ID HGF0679 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-4459 expresssion showed significantly downregulated in Helicobacter pylori infection (p-value<0.05). [8]
          hsa-miR-4270
             HGF ID HGF0677 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description Helicobacter pylori infection downregulated miR-4270 and that increased the expression of CD300E. [10]
          hsa-miR-370-5p
             HGF ID HGF0673 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of miR-370 was significantly down-regulated by Helicobacter pylori (p-value<0.05). [10]
          hsa-miR-361-3p
             HGF ID HGF0670 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-361-3p expresssion showed significantly downregulated in Helicobacter pylori infection (p-value<0.05). [8]
          hsa-miR-328-5p
             HGF ID HGF0667 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-328 downregulation occurred in Helicobacter pylori-infected gastric mucosa adjacent to gastric cancer compared with gastric mucosa not infected with Helicobacter pylori adjacent to gastric cancer (p-value<0.05). [11]
          hsa-miR-29b-1- 5p
             HGF ID HGF0664 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The Helicobacter pylori secreted antigen HP0175 upregulated miR-29b-1-5p. [10]
          hsa-miR-210-5p
             HGF ID HGF0660 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description Helicobacter pylori infection decreased the expression of miR-210 in the stomach tissue. [10]
          hsa-miR-18-5p
             HGF ID HGF0656 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of miR-18 was increased in Helicobacter pylori infection. [10]
          hsa-miR-152-5p
             HGF ID HGF0652 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description Helicobacter pylori increased the expression of PDL1/B7H1 by downregulated expression of miR-152. [10]
          hsa-miR-143- 3p
             HGF ID HGF0650 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-143-3p expression up-regulated in Helicobacter pylori-positive gastric cancer. [10]
          hsa-miR-142-5p
             HGF ID HGF0649 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The levels of miR-142-5p expression was significantly reduced after Helicobacter pylori eradication. [12]
          hsa-miR-133a-5p
             HGF ID HGF0643 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description Helicobacter pylori downregulated muscle-specific miR-133 in gastric tissue and myoblasts for increased cell proliferation and gastric emptying. [10]
          hsa-miR-1290
             HGF ID HGF0641 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-1290 expressipon was significantly upregulated with Helicobacter pylori infection (p-value<0.05). [13]
          hsa-miR-1289
             HGF ID HGF0640 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of miR-1289 was significantly up-regulated in Helicobacter pylori infection (p-value<0.05). [10]
          hsa-miR-124a-3
             HGF ID HGF0636 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-124a-3 methylation reduction expression was significantly associated with Helicobacter pylori eradication (p-value<0.05). [14]
          hsa-miR-124a-2
             HGF ID HGF0635 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-124a-2 methylation showed increased with Helicobacter pylori infection. [15]
          hsa-miR-106b-5p
             HGF ID HGF0287 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description Helicobacter pylori LPS induced the downregulation of miR-106b. [10]
          hsa-let-7c
             HGF ID HGF2377 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of Let-7c expression down-regulation in Helicobacter pylori-related gastric carcinogenesis. [10]
          hsa-let-7
             HGF ID HGF0590 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of let-7 expression was attenuated in Helicobacter pylori-related carcinogenesis. [10]
          hsa-let-7c-5p
             HGF ID HGF0589 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of Let-7c expression was at least 2-fold down-regulation in Helicobacter pylori-related gastric carcinogenesis. [16]
          hsa-miR-375-5p
             HGF ID HGF0543 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-375 inhibits Helicobacter pylori-induced gastric carcinogenesis by blocking JAK2-STAT3 signaling. [10]
          hsa-miR-372-5p
             HGF ID HGF0542 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-372 expressipon was significantly downregulated with Helicobacter pylori infection (p-value<0.05). [13]
          hsa-let-7a-5p
             HGF ID HGF0303 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of let-7a-5p was significantly down-regulated by Helicobacter pylori pathogensa (p-value<0.05). [8]
          hsa-let-7b-5p
             HGF ID HGF0300 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of let-7b expressipon was significantly upregulated with Helicobacter pylori infection (p-value<0.05). [8]
          hsa-miR-1-3p
             HGF ID HGF0294 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of miR-1 was significantly dowm-regulated by Helicobacter pylori (p-value<0.05). [10]
          hsa-miR-103a-3p
             HGF ID HGF0291 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of miR-103 was significantly down-regulated by Helicobacter pylori (p-value<0.05). [10]
          hsa-miR-135b-5p
             HGF ID HGF0264 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description Helicobacter pylori infection upregulated miR-135b-5p expression through a NF-B-dependent mechanism. [10]
          hsa-miR-146a-5p
             HGF ID HGF0252 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-146a was found to enhance the apoptosis in Helicobacter pylori-infected GC cell lines. [10]
          hsa-miR-155-5p
             HGF ID HGF0243 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-155 up-regulating expression could relieve the Helicobacter pylori-induced gastric inflammatory reaction. [17]
          hsa-miR-16-5p
             HGF ID HGF0240 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-16 expressipon was significantly upregulated with Helicobacter pylori infection (p-value<0.05). [8]
          hsa-miR-17-5p
             HGF ID HGF0239 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of miR-17 was significantly up-regulated in Helicobacter pylori infection (p-value<0.05). [10]
          hsa-miR-194-5p
             HGF ID HGF0222 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of miR-194 was significantly up-regulated in Helicobacter pylori infection (p-value<0.05). [10]
          hsa-miR-196a-5p
             HGF ID HGF0221 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of hsa-miR-196a-5p was decread by Helicobacter pylori eradication in normally infected individuals. [10]
          hsa-miR-200b-3p
             HGF ID HGF0212 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description Helicobacter pylori increased the expression of PDL1/B7H1 by downregulated expression of miR-200b in GC cell lines. [10]
          hsa-miR-200c-3p
             HGF ID HGF0210 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of miR-200c was significantly down-regulated in Helicobacter pylori infection (p-value<0.05). [10]
          hsa-miR-203a-3p
             HGF ID HGF0208 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-203 expression showed down-regulation induced by Helicobacter pylori infection. [10]
          hsa-miR-204-5p
             HGF ID HGF0207 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-204 expression was significantly down-regulated by Helicobacter pylori infection (p-value<0.05). [15]
          hsa-miR-21-5p
             HGF ID HGF0204 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of miR-21 was significantly up-regulated in Helicobacter pylori infection (p-value<0.05). [10]
          hsa-miR-212-3p
             HGF ID HGF0201 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-212-3p expressipon was significantly downregulated with Helicobacter pylori infection (p-value<0.05). [8]
          hsa-miR-222-3p
             HGF ID HGF0195 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-222 expression was significantly upregulated by Helicobacter pylori infection (p-value<0.05). [13]
          hsa-miR-223-3p
             HGF ID HGF0194 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of miR-223 was significantly upregulated in Helicobacter pylori infection (p-value<0.05). [10]
          hsa-miR-27b-3p
             HGF ID HGF0180 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of miR-27b was significantly up-regulated in Helicobacter pylori infection (p-value<0.05). [10]
          hsa-miR-30b-5p
             HGF ID HGF0167 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of miR-30b was significantly up-regulated in Helicobacter pylori infection (p-value<0.05). [10]
          hsa-miR-30d-5p
             HGF ID HGF0165 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description Helicobacter pylori upregulated miR-30d for autophagy suppression and increased intracellular survival. [10]
          hsa-miR-320a-3p
             HGF ID HGF0159 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of miR-320a was significantly down-regulated in Helicobacter pylori infection (p-value<0.05). [10]
          hsa-miR-371a-3p
             HGF ID HGF0142 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-371 expression was significantly downregulated by Helicobacter pylori infection (p-value<0.05). [8]
          hsa-miR-373-3p
             HGF ID HGF0141 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-373 expression was significantly downregulated by Helicobacter pylori infection (p-value<0.05). [13]
          hsa-miR-210
             HGF ID HGF2473 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description Epigenetic silencing of miR-210 increases the proliferation of gastric epithelium during chronic Helicobacter pylori infection. [18]
          hsa-miR-488-3p
             HGF ID HGF0124 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of Mir-488 was significantly up-regulated in Helicobacter pylori infection (p-value<0.05). [10]
          hsa-miR-491-5p
             HGF ID HGF0123 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of miR-491-5p was significantly down-regulated by Helicobacter pylori pathogensa (p-value<0.05). [8]
          hsa-miR-500a-5p
             HGF ID HGF0119 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of miR-500a-5p was significantly down-regulated by Helicobacter pylori pathogensa (p-value<0.05). [8]
          hsa-miR-532-5p
             HGF ID HGF0108 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-532 expression was significantly downregulated by Helicobacter pylori infection (p-value<0.05). [8]
          hsa-miR-584-5p
             HGF ID HGF0101 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-584 expression was significantly upregulated by Helicobacter pylori infection (p-value<0.05). [13]
          hsa-miR-7-5p
             HGF ID HGF0093 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of miR-7 was significantly down-regulated in Helicobacter pylori infection (p-value<0.05). [10]
          hsa-miR-99a-5p
             HGF ID HGF0082 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-99a expression was reduced in the gastric epithelium of Helicobacter pylori infection. [18]
          rs6912200
             HGF ID HGF2028 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The ORs of rs6912200 SNP was affected by Helicobacter pylori infection status. [19]
          rs4711690
             HGF ID HGF1424 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The ORs of rs4711690 SNP was affected by Helicobacter pylori infection status. [19]
          rs12229892
             HGF ID HGF1399 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The ORs of rs12229892 SNP was affected by Helicobacter pylori infection status. [19]
Host Immune Factors (HIFs)
          alpha-defensins
             HIF ID HIFM0087 HIF Info       Class Antimicrobial peptide (AMP)
             Description Helicobacter pylori infected stomach and in the colon in patients with ulcerative colitis produce alpha-defensins. [20]
          Human beta-defensin 1
             HIF ID HIFM0090 HIF Info       Class Antimicrobial peptide (AMP)
             Description The expression of HBD-1 exhibited enhanced antibacterial effect against Helicobacter pylori. [21]
          T-cell surface glycoprotein CD1c
             HIF ID HIFM0040 HIF Info       Class Checkpoint molecule (CM)
             Description CD1c may be involved in immune regulation by different bacterial steryl glycosides, including -cholesteryl acylated glucosides from Helicobacter pylori. [22]
          B7 homolog 3
             HIF ID HIFM0045 HIF Info       Class Checkpoint molecule (CM)
             Description Helicobacter pylori manipulates GECs to differentially express the B7-H3 molecules. [23]
          CEA cell adhesion molecule 1
             HIF ID HIFM0057 HIF Info       Class Checkpoint molecule (CM)
             Description CEACAM1 serves as a receptor for Helicobacter pylori pathogens in humans. [24]
          T cell immunoglobulin 3
             HIF ID HIFM0110 HIF Info       Class Checkpoint molecule (CM)
             Description Helicobacter pylori infection significantly elevated Tim-3 mRNA expression levels in RAW264.7 macrophages(p<0.01). [25]
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description We found that the rate of IgG anti-Helicobacter pylori seropositivity was significantly improved in IgA nephropathy. [26]
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description long time infection of Helicobacter pylori infection promoted the production of IgA. [26]
          Immunoglobulin A1
             HIF ID HIFM0275 HIF Info       Class Immunoglobulin (Ig)
             Description long time infection of Helicobacter pylori increased the antibodies against Helicobacter pylori, promoted the production of IgA1. [26]
          Immunoglobulin G4
             HIF ID HIFM0278 HIF Info       Class Immunoglobulin (Ig)
             Description IgG4 is associated with the abundance of Helicobacter pylori. [27]
          F4/80hiCD11b+CD64+CX3CR1+ macrophages
             HIF ID HIFC0225 HIF Info       Class Macrophages (Mac)
             Description The F4/80hiCD11b+CD64+CX3CR1+ macrophages can proliferate in situ in the gastric mucosa during Helicobacter pylori infection. [28]
          T cells
             HIF ID HIFC0002 HIF Info       Class T cells (TCs)
             Description Helicobacter pylori can modulate of effector T cells response. [29]
Environmental Factor(s)
             Disbiome ID
      1248
             gutMDisorder ID
      gm0367
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