Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0087)
HIF Name
alpha-defensins
HIF Synonym(s)
alpha-defensin
HIF Classification
Antimicrobial peptide (AMP)
Molecular Function
Antibiotic; Antimicrobial; Defensin; Fungicide
Description Human drosomycin-like defensin (Alpha-defensins) has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system. [1]
Pfam Defensin propeptide (PF00879 )
Mammalian defensin (PF00323 )
Pathway NOD-like receptor signaling pathway (hsa04621 )
Staphylococcus aureus infection (hsa05150 )
Transcriptional misregulation in cancer (hsa05202 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
DEF1_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Citrobacter rodentium (enterobacteria) MIC00366
             Description Addition of AAs inhibited maturation of alpha-defensins, which enhanced colonization of Citrobacter rodentium in the ileum. [2]
         Helicobacter pylori (epsilon-proteobacteria) MIC00669
             Description Helicobacter pylori infected stomach and in the colon in patients with ulcerative colitis produce alpha-defensins. [3]
         Salmonella enterica subsp. enterica (enterobacteria) MIC01154
             Description Alpha defensins which led to compromised host defense as manifested by enhanced colonization of Salmonella enterica serovar Typhimurium in the ileum. [2]
References
1 Antimicrobial peptides and the skin immune defense system.J Allergy Clin Immunol. 2008 Aug;122(2):261-6. doi: 10.1016/j.jaci.2008.03.027. Epub 2008 Apr 25.
2 Nutrient Sensing by the Intestinal Epithelium Orchestrates Mucosal Antimicrobial Defense via Translational Control of Hes1.Cell Host Microbe. 2019 May 8;25(5):706-718.e7. doi: 10.1016/j.chom.2019.03.012. Epub 2019 Apr 30.
3 Paneth cell -defensins and enteric microbiota in health and disease.Biosci Microbiota Food Health. 2016;35(2):57-67. doi: 10.12938/bmfh.2015-019. Epub 2015 Nov 26.

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