General Information of HIF (ID: HIFM0090)
HIF Name	Human beta-defensin 1
HIF Synonym(s)	Hbd-1, hBD-1, BD-1, beta-defensins
HIF Classification	Antimicrobial peptide (AMP)
Molecular Function	Antibiotic; Antimicrobial; Defensin
Description	hBD-1 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system.				[1]
Pfam	Beta defensin (PF00711 )
Pathway	ABC transporters (hsa02010 )
	Staphylococcus aureus infection (hsa05150 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	DEFB1_HUMAN
	APD ID	AP00451

Microbe Species (MIC) Regulated by This HIF
Actinomyces naeslundii (actinobacteria)			MIC00033
Description	Actinomyces naeslundii is susceptibility to human beta defensin 1.				[2]
Bifidobacterium animalis subsp. lactis (actinobacteria)			MIC00216
Description	Bifidobacterium animalis subsp. lactis HN019 showed increased susceptibility to 5 and 10 mg/mL of hBD-1 in the presence of carbonyl cyanide 3-chlorophenylhydrazone (CCCP) and Bifidobacterium animalis subsp. lactis HN019 were increased killed more than 20% by the concentration of hBD-1.				[3]
Bifidobacterium longum subsp. longum (actinobacteria)			MIC01876
Description	Bifidobacterium longum JDM301 showed increased susceptibility to 10 mg/mL of hBD-1 in the presence of carbonyl cyanide 3-chlorophenylhydrazone (CCCP) and Bifidobacterium longum JDM301 were increased killed 19.84% by the concentration of hBD-1.				[3]
Candida albicans (budding yeasts)			MIC00317
Description	The -defensin 1 was associated with the abundance of Candida albicans.				[4]
Chlamydia trachomatis (chlamydias)			MIC00344
Description	Chlamydia trachomatis induced variable increases of hBD-1 concentration.				[5]
Haemophilus influenzae (gamma-proteobacteria)			MIC00652
Description	Susceptibility of nontypeable Haemophilus influenzae to human -defensins 1 is influenced by lipooligosaccharide acylation.				[6]
Helicobacter pylori (epsilon-proteobacteria)			MIC00669
Description	The expression of HBD-1 exhibited enhanced antibacterial effect against Helicobacter pylori.				[7]
Lactobacillus rhamnosus (firmicutes)			MIC00732
Description	Lactobacillus rhamnosus GG showed increased killing percentage by hBD-1 at any tested concentration was no more than 4%.				[3]
Streptococcus mutans (firmicutes)			MIC01258
Description	Streptococcus mutans is susceptibility to human beta defensin 1.				[2]

References
1	APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2	Human beta-defensins 2 and 3 demonstrate strain-selective activity against oral microorganisms.J Clin Microbiol. 2004 Mar;42(3):1024-9. doi: 10.1128/jcm.42.3.1024-1029.2004.
3	Antimicrobial activity of human -defensins against lactic acid bacteria.Nat Prod Res. 2015;29(22):2164-6. doi: 10.1080/14786419.2014.996754. Epub 2015 Jan 6.
4	-Defensins: Farming the Microbiome for Homeostasis and Health.Front Immunol. 2019 Jan 25;9:3072. doi: 10.3389/fimmu.2018.03072. eCollection 2018.
5	[HBD-1 and hBD-2 are expressed in cervico-vaginal lavage in female genital tract due to microbial infections].Ginekol Pol. 2010 Apr;81(4):268-71.
6	Susceptibility of nontypeable Haemophilus influenzae to human beta-defensins is influenced by lipooligosaccharide acylation.Infect Immun. 2002 Sep;70(9):5287-9. doi: 10.1128/iai.70.9.5287-5289.2002.
7	A Novel View of Human Helicobacter pylori Infections: Interplay between Microbiota and Beta-Defensins.Biomolecules. 2019 Jun 18;9(6):237. doi: 10.3390/biom9060237.

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