Details of Microbe Species (MIC)
| General Information of MIC (ID: MIC00216) | |||||
|---|---|---|---|---|---|
| MIC Name | Bifidobacterium animalis subsp. lactis (actinobacteria) | ||||
| MIC Synonyms | Bifidobacterium lactis | ||||
| Body Site | Gut | ||||
| Lineage | Kingdom: Bacteria Phylum: Actinobacteria Class: Actinobacteria Order: Bifidobacteriales Family: Bifidobacteriaceae Genus: Bifidobacterium Species: Bifidobacterium animalis subsp. lactis | ||||
| Oxygen Sensitivity | Obligate anaerobe | ||||
| Microbial Metabolism | Saccharolytic, Fermentative | ||||
| Gram | Positive | ||||
| Host Relationship | Probiotic | ||||
| Genome Size (bp) | 1932693 | ||||
| No. of Coding Genes | 1536 | ||||
| No. of Non-Coding Genes | 65 | ||||
| No. of Small Non-Coding Genes | 65 | ||||
| No. of Gene Transcripts | 1601 | ||||
| No. of Base Pairs | 1938624 | ||||
| Description | Many strains of Bifidobacterium animalis subsp. lactis are considered health-promoting probiotic microorganisms and are commonly formulated into fermented dairy foods. | ||||
| External Links | Taxonomy ID | ||||
| Genome Assembly ID | |||||
| GOLD Organism ID | |||||
| Disease Relevance | |||||
| Inflammatory bowel disease [ICD-11: DD72] | |||||
| Description | The health-promoting properties of the commercialized strain Bifidobacterium animalis ssp. lactis Bb-12 (Bb-12) were associated with prevention of inflammatory bowel disease. | [1] | |||
| Irritable bowel syndrome [ICD-11: DD91] | |||||
| Description | Bifidobacterium lactis was associated with chronic constipation. | [2] | |||
| Host Genetic Factors (HGFs) | |||||
|---|---|---|---|---|---|
| rs651821 | |||||
| HGF ID | HGF1924 | HGF Info | Class | Single Nucleotide Polymorphism: Prime UTR variant (SNP-PV) | |
| Description | The APOA5 SNP rs651821 might be an important host genetic factor in determining the abundances of the health-promoting Bifidobacterium bacteria and the taxa to which this genus belongs. | [3] | |||
| rs5743399 | |||||
| HGF ID | HGF1974 | HGF Info | Class | Single Nucleotide Polymorphism (SNP) | |
| Description | The rs5743399 SNP showed an interaction with HN019 in that children with this variant who were in the HN019 treatment group showed a significantly reduced risk of eczema (p-value=0.0070). | [4] | |||
| rs3815735 | |||||
| HGF ID | HGF1320 | HGF Info | Class | Single Nucleotide Polymorphism: Intron variant (SNP-IV) | |
| Description | The rs3815735 SNP showed an interaction with HN019 in that children with this variant who were in the HN019 treatment group showed a significantly reduced risk of eczema (p-value=0.0084). | [4] | |||
| rs2107356 | |||||
| HGF ID | HGF1724 | HGF Info | Class | Single Nucleotide Polymorphism: Upstream variant (SNP-UV) | |
| Description | The rs2107356 SNP showed an interaction with HN019 in that children with this variant who were in the HN019 treatment group showed a significantlyreduced risk of eczema (p-value=0.0127). | [4] | |||
| Host Immune Factors (HIFs) | |||||
|---|---|---|---|---|---|
| C-C motif chemokine 22 | |||||
| HIF ID | HIFM0025 | HIF Info | Class | Antimicrobial peptide (AMP) | |
| Description | The abundance of circulating CCL22 was lower in the group supplemented with Bifidobacterium animalis subsp.lactis. | [5] | |||
| Human beta-defensin 1 | |||||
| HIF ID | HIFM0090 | HIF Info | Class | Antimicrobial peptide (AMP) | |
| Description | Bifidobacterium animalis subsp. lactis HN019 showed increased susceptibility to 5 and 10 mg/mL of hBD-1 in the presence of carbonyl cyanide 3-chlorophenylhydrazone (CCCP) and Bifidobacterium animalis subsp. lactis HN019 were increased killed more than 20% by the concentration of hBD-1. | [6] | |||
| CD19+ B cells | |||||
| HIF ID | HIFC0092 | HIF Info | Class | B cells (BCs) | |
| Description | Bifidobacterium animalis subsp.lactis Bi-07 supplementation reduced the expression of CD19+B cells. | [7] | |||
| Interferon-12 subunit alpha | |||||
| HIF ID | HIFM0130 | HIF Info | Class | Cytokine (Cyt) | |
| Description | Bifidobacterium animalis subsp.lactis HN019 promoted a Th1 immune response through an increase expression in IL-12. | [8] | |||
| Interleukin-23 subunit alpha | |||||
| HIF ID | HIFM0144 | HIF Info | Class | Cytokine (Cyt) | |
| Description | Bifidobacterium animalis subsp.lactis HN019 promote a Th1immune response through an increase expression in IL-23. | [8] | |||
| Immunoglobulin G | |||||
| HIF ID | HIFM0270 | HIF Info | Class | Immunoglobulin (Ig) | |
| Description | The abundance of Bifidobacterium animalis subsp.lactis HN019 is associated with IgG immune response. | [8] | |||
| CD4+ helper T cells | |||||
| HIF ID | HIFC0068 | HIF Info | Class | T cells (TCs) | |
| Description | Bifidobacterium animalis subsp. lactis has the intrinsic ability to promote a Th1 immune response through an increase in IL-12/IL-23. | [8] | |||
| Environmental Factor(s) | |||||
|---|---|---|---|---|---|
| Disbiome ID | |||||
| gutMDisorder ID | |||||
If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.