Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0144)
HIF Name
Interleukin-23 subunit alpha
HIF Synonym(s)
interleukin 23 subunit alpha, IL23A, P19, SGRF, IL-23, IL-23A, IL23P19
HIF Classification
Cytokine (Cyt)
Molecular Function
Cytokine
Description IL23A A gene on chromosome 12q13.13 that encodes interleukin-23A, a cytokine which associates with IL-12B to form IL-23, a heterodimeric cytokine involved in innate and adaptive immunity. [1]
Pfam Interleukin 23 subunit alpha (PF16649 )
Pathway C-type lectin receptor signaling pathway (hsa04625 )
Cytokine-cytokine receptor interaction (hsa04060 )
Inflammatory bowel disease (IBD) (hsa05321 )
JAK-STAT signaling pathway (hsa04630 )
Pathways in cancer (hsa05200 )
Pertussis (hsa05133 )
Rheumatoid arthritis (hsa05323 )
Th17 cell differentiation (hsa04659 )
Tuberculosis (hsa05152 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
IL23A_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Bifidobacterium animalis subsp. lactis (actinobacteria) MIC00216
             Description Bifidobacterium animalis subsp.lactis HN019 promote a Th1immune response through an increase expression in IL-23. [2]
         Bordetella pertussis (beta-proteobacteria) MIC00248
             Description A TLR2 agonist from Bordetella pertussis could synergistically induces production of IL-23 through activiate the enzymatic activity. [3]
         Burkholderia cenocepacia (beta-proteobacteria) MIC00280
             Description Burkholderia cenocepacia induced high expression of inflammatory cytokines IL-23. [4]
         Clostridium leptum (firmicutes) MIC00402
             Description Early-life Clostridium leptum exposure induced an immunosuppressive environment in the lung concurrent with increased Treg cells, resulting in the inhibition of Th17 cell responses,which were associated with IL-23 production. [5]
         Corynebacterium accolens (actinobacteria) MIC00448
             Description Corynebacterium accolens alone can promote inflammation in an IL-23dependent manner. [6]
         Lactococcus lactis (firmicutes) MIC00745
             Description Lactococcus lactis had significantly (p<0.05) elevated IL-23 expression. [7]
         Mycoplasma hominis (mycoplasmas) MIC00871
             Description Mycoplasma hominis could induce a predominant IL-23 secretion. [8]
         Peptostreptococcus anaerobius (firmicutes) MIC00980
             Description IL23A genes was overexpressed and cancer-related bacteria(Peptostreptococcus and Bacteroides fragilis) enriched in the high-risk tumors. [9]
         Prevotella copri (CFB bacteria) MIC01010
             Description The magnitude of Prevotella copri IgA antibodies has strong positive correlations IL-23 expression. [10]
         Prevotella salivae (CFB bacteria) MIC01023
             Description Prevotella salivae stimulate the release of IL23 by dendritic cells (DC) through Tolllike receptor 2. [11]
         Salmonella enterica subsp. enterica (enterobacteria) MIC01154
             Description Salmonella typhimurium is associated with IL-23 expression. [12]
References
1 The Genetics of Chronic Itch: Gene Expression in the Skin of Patients with Atopic Dermatitis and Psoriasis with SevereItch.J Invest Dermatol. 2018 Jun;138(6):1311-1317. doi: 10.1016/j.jid.2017.12.029. Epub 2018 Jan 6.
2 Investigation of the immunomodulatory effects of Lactobacillus casei and Bifidobacterium lactis on Helicobacter pylori infection. Helicobacter. 2008 Jun;13(3):183-90. doi: 10.1111/j.1523-5378.2008.00595.x.
3 Sustained protective immunity against Bordetella pertussis nasal colonization by intranasal immunization with a vaccine-adjuvant combination that induces IL-17-secreting T(RM) cells. Mucosal Immunol. 2018 Nov;11(6):1763-1776. doi: 10.1038/s41385-018-0080-x. Epub 2018 Aug 20.
4 Using dendritic cells to evaluate how Burkholderia cenocepacia clonal isolates from a chronically infected cystic fibrosis patient subvert immune functions. Med Microbiol Immunol. 2017 Apr;206(2):111-123. doi: 10.1007/s00430-016-0488-4. Epub 2016 Dec 16.
5 Early-Life Exposure to Clostridium leptum Causes Pulmonary Immunosuppression. PLoS One. 2015 Nov 13;10(11):e0141717. doi: 10.1371/journal.pone.0141717. eCollection 2015.
6 Contextual control of skin immunity and inflammation by Corynebacterium. J Exp Med. 2018 Mar 5;215(3):785-799. doi: 10.1084/jem.20171079. Epub 2018 Jan 30.
7 Production and delivery of Helicobacter pylori NapA in Lactococcus lactis and its protective efficacy and immune modulatory activity. Sci Rep. 2018 Apr 24;8(1):6435. doi: 10.1038/s41598-018-24879-x.
8 Interaction of Mycoplasma hominis PG21 with Human Dendritic Cells: Interleukin-23-Inducing Mycoplasmal Lipoproteins and Inflammasome Activation of the Cell. J Bacteriol. 2017 Jul 11;199(15):e00213-17. doi: 10.1128/JB.00213-17. Print 2017 Aug 1.
9 High-risk Stage III colon cancer patients identified by a novel five-gene mutational signature are characterized by upregulation of IL-23A and gut bacterial translocation of the tumor microenvironment. Int J Cancer. 2020 Apr 1;146(7):2027-2035. doi: 10.1002/ijc.32775. Epub 2019 Nov 27.
10 Evidence of the Immune Relevance of Prevotella copri, a Gut Microbe, in Patients With Rheumatoid Arthritis. Arthritis Rheumatol. 2017 May;69(5):964-975. doi: 10.1002/art.40003. Epub 2017 Apr 7.
11 The immune response to Prevotella bacteria in chronic inflammatory disease. Immunology. 2017 Aug;151(4):363-374. doi: 10.1111/imm.12760. Epub 2017 Jun 20.
12 Salmonella Typhimurium, the major causative agent of foodborne illness inactivated by a phage lysis system provides effective protection against lethal challenge by induction of robust cell-mediated immune responses and activation of dendritic cells. Vet Res. 2017 Oct 25;48(1):66. doi: 10.1186/s13567-017-0474-x.

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