Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00745)
MIC Name Lactococcus lactis (firmicutes)
MIC Synonyms Bacterium lactis
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Lactococcus
Species: Lactococcus lactis
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Respiratory or Fermentative
Gram Positive
Genome Size (bp) 2365589
No. of Coding Genes 2197
No. of Non-Coding Genes 80
No. of Small Non-Coding Genes 80
No. of Gene Transcripts 2277
No. of Base Pairs 2398091
Description Lactococcus lactis is a facultative anaerobic, Gram positive non-sporulating and non-motile bacterium.
External Links Taxonomy ID
1358
Genome Assembly ID
ASM76111v1
GOLD Organism ID
Go0034085
Disease Relevance
          Inflammatory bowel disease  [ICD-11: DD72]
             Description LcrV-secreting Lactococcus lactis decreased experimentally induced intestinal inflammation in 2 models of colitis. [1]
Host Genetic Factors (HGFs)
          rs2294239
             HGF ID HGF1223 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs2294239 SNP was associated with the abundance of Lactococcus bacteria (p-value<0.05). [2]
          rs3747113
             HGF ID HGF1324 HGF Info       Class Single Nucleotide Polymorphism: Non coding transcript variant (SNP-NCTV)
             Description The rs3747113 SNP was significantly associated with the abundance of Lactococcus (p-value=9.70E-07). [3]
          rs11236806
             HGF ID HGF1665 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs11236806 SNP was significantly associated with the relative abundance of Lactococcus (p-value=2.75E-08). [4]
          rs10148302
             HGF ID HGF1842 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs10148302 SNP was significantly associated with the relative abundance of Lactococcus (p-value=8.23E-10). [4]
Host Immune Factors (HIFs)
          C-C motif chemokine 17
             HIF ID HIFM0019 HIF Info       Class Antimicrobial peptide (AMP)
             Description Lactococcus species strains decreased CCL17 secretion without affecting cell viability. [5]
          Elafin
             HIF ID HIFM0095 HIF Info       Class Antimicrobial peptide (AMP)
             Description The creation of engineered Lactococcus lactis which produces elafin, also known as peptidase inhibitor 3 or skin-derived antileukoprotease (SKALP). [6]
          Interleukin-17A
             HIF ID HIFM0134 HIF Info       Class Cytokine (Cyt)
             Description Lactococcus lactis could increase IL-17 expression. [7]
          Interleukin-1 beta
             HIF ID HIFM0138 HIF Info       Class Cytokine (Cyt)
             Description Significant increases in IL-1beta levels was found in Lactococcus lactis-inoculated glands. [8]
          Interleukin-23 subunit alpha
             HIF ID HIFM0144 HIF Info       Class Cytokine (Cyt)
             Description Lactococcus lactis had significantly (p<0.05) elevated IL-23 expression. [7]
          CD39+ regulatory T cells
             HIF ID HIFC0048 HIF Info       Class T cells (TCs)
             Description Lactococcus lactis can induced the expansion of CD39+ Tregs. [9]
          CD4+ helper T cells
             HIF ID HIFC0068 HIF Info       Class T cells (TCs)
             Description Certain Lactococcus lactis strains isolated from the environment were proved capable of promoting Th1 bias immune response. [7]
          T helper type 17 cells
             HIF ID HIFC0080 HIF Info       Class T cells (TCs)
             Description The Lactococcus lactis-delivered NapA(neutrophil-activating protein A subunit) can drive a polarized Th17 response. [7]
Environmental Factor(s)
             Disbiome ID
      1047
             gutMDisorder ID
      gm0415
References
1 Prevention and treatment of colitis with Lactococcus lactis secreting the immunomodulatory Yersinia LcrV protein. Gastroenterology. 2007 Sep;133(3):862-74. doi: 10.1053/j.gastro.2007.06.018. Epub 2007 Jun 20.
2 The effect of host genetics on the gut microbiome.Nat Genet. 2016 Nov;48(11):1407-1412. doi: 10.1038/ng.3663. Epub 2016 Oct 3.
3 Genome-Wide Association Studies of the Human Gut Microbiota.PLoS One. 2015 Nov 3;10(11):e0140301. doi: 10.1371/journal.pone.0140301. eCollection 2015.
4 Association of host genome with intestinal microbial composition in a large healthy cohort.Nat Genet. 2016 Nov;48(11):1413-1417. doi: 10.1038/ng.3693. Epub 2016 Oct 3.
5 D-tryptophan from probiotic bacteria influences the gut microbiome and allergic airway disease.J Allergy Clin Immunol. 2017 May;139(5):1525-1535. doi: 10.1016/j.jaci.2016.09.003. Epub 2016 Sep 23.
6 Microbiota effects on cancer: from risks to therapies.Oncotarget. 2018 Apr 3;9(25):17915-17927. doi: 10.18632/oncotarget.24681. eCollection 2018 Apr 3.
7 Production and delivery of Helicobacter pylori NapA in Lactococcus lactis and its protective efficacy and immune modulatory activity. Sci Rep. 2018 Apr 24;8(1):6435. doi: 10.1038/s41598-018-24879-x.
8 A mouse mastitis model to study the effects of the intramammary infusion of a food-grade Lactococcus lactis strain. PLoS One. 2017 Sep 5;12(9):e0184218. doi: 10.1371/journal.pone.0184218. eCollection 2017.
9 The influence of gut-derived CD39 regulatory T cells in CNS demyelinating disease.Transl Res. 2017 Jan;179:126-138. doi: 10.1016/j.trsl.2016.07.016. Epub 2016 Jul 28.

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