Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0019)
HIF Name
C-C motif chemokine 17
HIF Synonym(s)
Ccl17, TARC, Small-inducible cytokine A17, Thymus and activation-regulated chemokine
HIF Classification
Antimicrobial peptide (AMP)
Molecular Function
Cytokine
Description CCL17 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system. [1]
Pfam Small cytokines (intecrine/chemokine), interleukin-8 like (PF00048 )
Pathway C-type lectin receptor signaling pathway (hsa04625 )
Chemokine signaling pathway (hsa04062 )
Cytokine-cytokine receptor interaction (hsa04060 )
IL-17 signaling pathway (hsa04657 )
Viral protein interaction with cytokine and cytokine receptor (hsa04061 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
CCL17_HUMAN
APD ID
AP02093
Microbe Species (MIC) Regulated by This HIF
         Bifidobacterium sp. (actinobacteria) MIC00224
             Description Bifidobacterium species strains decreased CCL17 secretion without affecting cell viability. [2]
         Lactobacillus rhamnosus (firmicutes) MIC00732
             Description The expression of CCL17 concentrations was associated with the nonprobiotic Lactobacillus rhamnosus DSM-20021. [2]
         Lactococcus lactis (firmicutes) MIC00745
             Description Lactococcus species strains decreased CCL17 secretion without affecting cell viability. [2]
         Prevotella sp. (CFB bacteria) MIC01024
             Description Patients with a Prevotella-rich gut enterotype displayed increased serum levels of the chemokines CCL17. [3]
         Veillonella parvula (firmicutes) MIC01365
             Description Veillonella can increase the CCL17 expression. [4]
References
1 APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2 D-tryptophan from probiotic bacteria influences the gut microbiome and allergic airway disease.J Allergy Clin Immunol. 2017 May;139(5):1525-1535. doi: 10.1016/j.jaci.2016.09.003. Epub 2016 Sep 23.
3 Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients.Nat Commun. 2019 Dec 13;10(1):5711. doi: 10.1038/s41467-019-13751-9.
4 Infant airway microbiota and topical immune perturbations in the origins of childhood asthma.Nat Commun. 2019 Nov 1;10(1):5001. doi: 10.1038/s41467-019-12989-7.

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