Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01365)
MIC Name Veillonella parvula (firmicutes)
MIC Synonyms Staphylococcus parvulus
Body Site Mucosa
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Negativicutes
Order: Veillonellales
Family: Veillonellaceae
Genus: Veillonella
Species: Veillonella parvula
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Asaccharolytic; Ferment TCA cycle intermediates
Gram Negative
Host Relationship Commensal
Genome Size (bp) 2132142
No. of Coding Genes 924
No. of Non-Coding Genes 33
No. of Small Non-Coding Genes 33
No. of Gene Transcripts 965
No. of Pseudogenes 8
No. of Base Pairs 1068538
Description Veillonella parvula is an obligate anaerobic, Gram negative, non-spore-forming coccus-shaped bacterium. It is found in the gut of humans and dental plaque. It is a normal part of the oral flora but can be associated with diseases such as periodontitis and dental caries as well as various systemic infections.
External Links Taxonomy ID
29466
Genome Assembly ID
ASM148702v1
GOLD Organism ID
Go0476775
Disease Relevance
          Autoimmune liver disease  [ICD-11: DB96]
             Description Veillonella parvula was associated with primary sclerosing cholangitis. [1]
          Bacterial meningitis  [ICD-11: 1D01]
             Description Veillonella parvula can cause bacterial meningitis. [2]
          Crohn disease  [ICD-11: DD70]
             Description Veillonella has been previously associated with intestinal inflammation in Crohns disease patients. [3]
          Inflammatory bowel disease  [ICD-11: DD72]
             Description Veillonella parvula is upregulated in inflammatory bowel disease. [1]
          Irritable bowel syndrome  [ICD-11: DD91]
             Description Quantity of Veillonella significantly increased in irritable bowel syndrome patients than control. [4]
          Irritable bowel syndrome  [ICD-11: DD91]
             Description Patients with constipation-predominant IBS(Irritable bowel syndrome) had increased amounts of Veillonella species. [5]
          Meningococcal disease  [ICD-11: 1C1C]
             Description Veillonella parvula was associated with bacteraemia. [6]
          Osteomyelitis or osteitis  [ICD-11: FB84]
             Description Veillonella parvula can caued osteomyelitis. [6]
          Periodontal disease  [ICD-11: DA0C]
             Description Oral Veillonella parvula is involved in the development of early periodontal disease. [7]
          Ulcerative colitis  [ICD-11: DD71]
             Description Veillonella was markedly overrepresented in primary sclerosing cholangitis regardless of concomitant inflammatory bowel disease. [1]
Host Genetic Factors (HGFs)
          rs2820092
             HGF ID HGF1857 HGF Info       Class Single Nucleotide Polymorphism: Synonymous variant (SNP-SV)
             Description The rs2820092 SNP was significantly associated with the abundance of Veillonella (p-value=2.41E-06). [8]
          rs2229383
             HGF ID HGF1719 HGF Info       Class Single Nucleotide Polymorphism: Synonymous variant (SNP-SV)
             Description The rs2229383 SNP was significantly associated with the abundance of Veillonella (p-value=4.07E-07). [8]
          rs12258196
             HGF ID HGF1805 HGF Info       Class Single Nucleotide Polymorphism: Synonymous variant (SNP-SV)
             Description The rs12258196 SNP was significantly associated with the abundance of Veillonella (p-value=1.46E-06). [8]
          rs10906011
             HGF ID HGF1804 HGF Info       Class Single Nucleotide Polymorphism: Synonymous variant (SNP-SV)
             Description The rs10906011 SNP was significantly associated with the abundance of Veillonella (p-value=4.02E-06). [8]
          rs3091315
             HGF ID HGF2612 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs3091315 SNP is associated with the abundance of Veillonella parvula. [9]
          rs11150589
             HGF ID HGF2659 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-UV)
             Description The rs11150589 SNP is associated with the abundance of Veillonella parvula. [9]
          rs7097656
             HGF ID HGF2572 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs7097656 SNP is associated with the abundance of Veillonella parvula. [9]
          rs7134599
             HGF ID HGF2634 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs7134599 SNP is associated with the abundance of Veillonella parvula. [9]
          rs13407913
             HGF ID HGF2607 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs13407913 SNP is associated with the abundance of Veillonella parvula. [9]
          rs561722
             HGF ID HGF2632 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs561722 SNP is associated with the abundance of Veillonella parvula. [9]
          rs13126505
             HGF ID HGF2650 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs13126505 SNP is associated with the abundance of Veillonella parvula. [9]
          rs7438704
             HGF ID HGF2661 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs7438704 SNP is associated with the abundance of Veillonella parvula. [9]
          rs6863411
             HGF ID HGF2662 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs6863411 SNP is associated with the abundance of Veillonella parvula. [9]
Host Immune Factors (HIFs)
          C-C motif chemokine 17
             HIF ID HIFM0019 HIF Info       Class Antimicrobial peptide (AMP)
             Description Veillonella can increase the CCL17 expression. [10]
          Interferon-10
             HIF ID HIFM0128 HIF Info       Class Cytokine (Cyt)
             Description A specific p38 MAPK inhibitor strongly inhibited Veillonella parvula LPS-induced IL-10 through reducing enzyme activity. [7]
          Interleukin-1 beta
             HIF ID HIFM0138 HIF Info       Class Cytokine (Cyt)
             Description Veillonella parvula has been demonstrated to induce the release of IL-1beta in human blood monocytes. [7]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Veillonella parvula lipopolysaccharide stimulated IL-6 release in human peripheral blood mononuclear cells (PBMC) in a dose-dependent manner. [7]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description Veillonella parvula lipopolysaccharide stimulated tumor necrosis factor alpha (TNF-Alpha) and interleukin-6 (IL-6) release in human peripheral blood mononuclear cells (PBMC) in a dose-dependent manner. [7]
          Neutrophils
             HIF ID HIFC0029 HIF Info       Class Granulocytes (Gra)
             Description Veillonella parvula at neutrophil recovery was positively correlated with subsequent acute severe graft-versus-host disease. [11]
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description Veillonella spp.was selectively IgA+ (High IgA binding) coated in patients with inflammatory bowel disease (Crohn disease and ulcerative colitis). [12]
          Peripheral blood mononuclear cells
             HIF ID HIFC0026 HIF Info       Class Monocytes (Mono)
             Description Veillonella parvula lipopolysaccharide stimulated tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) release in human peripheral blood mononuclear cells (PBMC) in a dose-dependent manner. [7]
          P38 signaling pathway
             HIF ID HIFP0031 HIF Info       Class Signaling pathway (SP)
             Description Veillonella parvula lipopolysaccharide could activate the human PBMC p38 mitogen-activated protein kinase (MAPK). [7]
          T-cell surface glycoprotein CD4
             HIF ID HIFM0050 HIF Info       Class T-cell receptor (TCR)
             Description HIV-pneumonia patients with low CD4 counts exhibited enrichment of specific Veillonella. [13]
          Toll-like receptor 4
             HIF ID HIFM0219 HIF Info       Class Toll-like receptor (TLR)
             Description A TLR4 antagonist can block Veillonella parvula LPS-induced cytokine production. [7]
Environmental Factor(s)
             Disbiome ID
      346
             gutMDisorder ID
      gm0678
References
1 Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis. World J Gastroenterol. 2017 Jul 7;23(25):4548-4558. doi: 10.3748/wjg.v23.i25.4548.
2 Bacterial meningitis caused by Veillonella parvula. Acta Paediatr Jpn. 1989 Oct;31(5):609-14. doi: 10.1111/j.1442-200x.1989.tb01363.x.
3 Pretreatment gut microbiome predicts chemotherapy-related bloodstream infection. Genome Med. 2016 Apr 28;8(1):49. doi: 10.1186/s13073-016-0301-4.
4 The gut microbiota and irritable bowel syndrome: friend or foe. Int J Inflam. 2012;2012:151085. doi: 10.1155/2012/151085. Epub 2012 Apr 22.
5 Pathogenic factors involved in the development of irritable bowel syndrome: focus on a microbial role. Infect Dis Clin North Am. 2010 Dec;24(4):961-75, ix. doi: 10.1016/j.idc.2010.07.005.
6 Non-vertebral Veillonella species septicemia and osteomyelitis in a patient with diabetes: a case report and review of the literature. J Med Case Rep. 2014 Nov 12;8:365. doi: 10.1186/1752-1947-8-365.
7 Receptor recognition of and immune intracellular pathways for Veillonella parvula lipopolysaccharide. Clin Vaccine Immunol. 2009 Dec;16(12):1804-9. doi: 10.1128/CVI.00310-09. Epub 2009 Oct 14.
8 Host genetic variation impacts microbiome composition across human body sites.Genome Biol. 2015 Sep 15;16(1):191. doi: 10.1186/s13059-015-0759-1.
9 A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice. Genetics. 2020 Mar;214(3):719-733. doi: 10.1534/genetics.119.303013. Epub 2020 Jan 2.
10 Infant airway microbiota and topical immune perturbations in the origins of childhood asthma.Nat Commun. 2019 Nov 1;10(1):5001. doi: 10.1038/s41467-019-12989-7.
11 Stool Microbiota at Neutrophil Recovery Is Predictive for Severe Acute Graft vs Host Disease After Hematopoietic Cell Transplantation.Clin Infect Dis. 2017 Nov 29;65(12):1984-1991. doi: 10.1093/cid/cix699.
12 IgA Function in Relation to the Intestinal Microbiota.Annu Rev Immunol. 2018 Apr 26;36:359-381. doi: 10.1146/annurev-immunol-042617-053238. Epub 2018 Jan 26.
13 Gut microbiota in HIV-pneumonia patients is related to peripheral CD4 counts, lung microbiota, and in vitro macrophage dysfunction. Microbiome. 2019 Mar 11;7(1):37. doi: 10.1186/s40168-019-0651-4.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.