General Information of HIF (ID: HIFP0031)
HIF Name	P38 signaling pathway
HIF Synonym(s)	p38, p38 signaling pathway
HIF Classification	Signaling pathway (SP)
Description	The p38 pathway is the third major signaling cassettes of the mitogen-activated protein kinase (MAPK) signaling pathway. It functions in the control of apoptosis and the release of cytokines by macrophages and neutrophils.				[1]

Microbe Species (MIC) Regulated by This HIF
Pseudomonas mendocina (gamma-proteobacteria)			MIC01057
Description	Pseudomonas mendocina depended on weak induction of immune genes regulated by the p38 MAPK pathway.				[2]
Saccharomyces cerevisiae (budding yeasts)			MIC01145
Description	Saccharomyces cerevisiae could inhibite ETEC-Mediated p38 Signaling Pathways.				[3]
Veillonella parvula (firmicutes)			MIC01365
Description	Veillonella parvula lipopolysaccharide could activate the human PBMC p38 mitogen-activated protein kinase (MAPK).				[4]

References
1	Targeting p38 MAP kinase signaling in cancer through post-translational modifications.Cancer Lett. 2017 Jan 1;384:19-26. doi: 10.1016/j.canlet.2016.10.008. Epub 2016 Oct 8.
2	Association with soil bacteria enhances p38-dependent infection resistance in Caenorhabditis elegans. Infect Immun. 2013 Feb;81(2):514-20. doi: 10.1128/IAI.00653-12. Epub 2012 Dec 10.
3	Saccharomyces cerevisiae modulates immune gene expressions and inhibits ETEC-mediated ERK1/2 and p38 signaling pathways in intestinal epithelial cells. PLoS One. 2011 Apr 4;6(4):e18573. doi: 10.1371/journal.pone.0018573.
4	Receptor recognition of and immune intracellular pathways for Veillonella parvula lipopolysaccharide. Clin Vaccine Immunol. 2009 Dec;16(12):1804-9. doi: 10.1128/CVI.00310-09. Epub 2009 Oct 14.

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