Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0050)
HIF Name
T-cell surface glycoprotein CD4
HIF Synonym(s)
CD4 molecule, CD4mut
HIF Classification
T-cell receptor (TCR)
Molecular Function
Host cell receptor for virus entry; Receptor
Description In molecular biology, CD4 is a glycoprotein found on the surface ofimmune cells such as T helper cells, monocytes, macrophages, anddendritic cells. [1]
Pfam CD4, extracellular (PF09191 )
Immunoglobulin C2-set domain (PF05790 )
Immunoglobulin domain (PF00047 )
T cell CD4 receptor C terminal region (PF12104 )
Pathway Antigen processing and presentation (hsa04612 )
Cell adhesion molecules (CAMs) (hsa04514 )
Cytokine-cytokine receptor interaction (hsa04060 )
Hematopoietic cell lineage (hsa04640 )
Human T-cell leukemia virus 1 infection (hsa05166 )
Human immunodeficiency virus 1 infection (hsa05170 )
PD-L1 expression and PD-1 checkpoint pathway in cancer (hsa05235 )
Primary immunodeficiency (hsa05340 )
T cell receptor signaling pathway (hsa04660 )
Th1 and Th2 cell differentiation (hsa04658 )
Th17 cell differentiation (hsa04659 )
Yersinia infection (hsa05135 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
CD4_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Bacteroides sp. (CFB bacteria) MIC00176
             Description The stool of HIV-infected patients with high CD4 counts were enriched for traditional gastrointestinal genera Bacteroides(false discovery rate q < 0.05, read difference 100 reads, and presence in 50%). [2]
         Escherichia coli (enterobacteria) MIC00516
             Description Escherichia coli and B animalis reactive CD4+ T-cell lines were strongly restimulated when cultured with autologous monocytes loaded with Escherichia coli or B animalis lysates. [3]
         Lactobacillus sp. (firmicutes) MIC00701
             Description HIV-pneumonia patients with low CD4 counts exhibited enrichment of specific Lactobacillales(false discovery rate q < 0.05, read difference 100 reads, and presence in 50%). [2]
         Megasphaera elsdenii (firmicutes) MIC00788
             Description HIV-pneumonia patients with low CD4 counts exhibited enrichment of specific Megasphaera(false discovery rate q < 0.05, read difference 100 reads, and presence in 50%). [2]
         Prevotella sp. (CFB bacteria) MIC01024
             Description The stool of HIV-infected patients with high CD4 counts were enriched for traditional gastrointestinal genera Prevotella(false discovery rate q < 0.05, read difference 100 reads, and presence in 50%). [2]
         Ruminococcus sp. (firmicutes) MIC01140
             Description The stool of HIV-infected patients with high CD4 counts were enriched for traditional gastrointestinal genera Ruminococcus(false discovery rate q < 0.05, read difference 100 reads, and presence in 50%). [2]
         Streptococcus sp. (firmicutes) MIC01276
             Description HIV-pneumonia patients with low CD4 counts exhibited enrichment of specific Streptococcus. [2]
         Veillonella parvula (firmicutes) MIC01365
             Description HIV-pneumonia patients with low CD4 counts exhibited enrichment of specific Veillonella. [2]
References
1 Do Memory CD4 T Cells Keep Their Cell-Type Programming: Plasticity versus Fate Commitment Complexities of Interpretation due to the Heterogeneity of Memory CD4 T Cells, Including T Follicular Helper Cells.Cold Spring Harb Perspect Biol. 2018 Mar 1;10(3):a032102. doi: 10.1101/cshperspect.a032102.
2 Gut microbiota in HIV-pneumonia patients is related to peripheral CD4 counts, lung microbiota, and in vitro macrophage dysfunction. Microbiome. 2019 Mar 11;7(1):37. doi: 10.1186/s40168-019-0651-4.
3 Circulating and Tissue-Resident CD4(+) T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation. Gastroenterology. 2017 Nov;153(5):1320-1337.e16. doi: 10.1053/j.gastro.2017.07.047. Epub 2017 Aug 4.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.