General Information of MIC (ID: MIC00176)
MIC Name	Bacteroides sp. (CFB bacteria)
Body Site	Gut
Lineage	Kingdom: Bacteria Phylum: Bacteroidetes Class: Bacteroidia Order: Bacteroidales Family: Bacteroidaceae Genus: Bacteroides Species: Bacteroides sp.
Oxygen Sensitivity	Obligate anaerobe
Microbial Metabolism	Saccharolytic, Fermentative
Gram	Negative
Host Relationship	Opportunistic pathogen; Commensal
Description	Bacteroides is a genus of Gram-negative, obligate anaerobic bacteria. Bacteroides species are non endospore-forming bacilli, and may be either motile or nonmotile, depending on the species.
External Links	Taxonomy ID	29523
	GOLD Organism ID	Go0004785
Disease Relevance
Chronic kidney disease  [ICD-11: GB61]
Description	Bacteroidaceae was associated with chronic kidney disease.				[1]
Crohn disease  [ICD-11: DD70]
Description	Crohns disease-associated microbiota are characterized by the omnipresence of Bacteroides.				[2]
Depression  [ICD-11: 6A70]
Description	An increase in Bacteroidaceae has been observed in patients with depression.				[3]
Inflammatory bowel disease  [ICD-11: DD72]
Description	Species diversity of Bacteroidales was decreased in inflammatory bowel disease compared to controls and with increasingly inflamed tissue.				[4]
Irritable bowel syndrome  [ICD-11: DD91]
Description	An increase in Bacteroidaceae has been observed in patients with irritable Bowel Syndrome.				[3]
Liver cirrhosis  [ICD-11: DB93]
Description	Bacteroides sp. in the oropharyngeal microbiome was associated with liver cirrhosis.				[5]
Peptic ulcer  [ICD-11: DA61]
Description	Elevated content of Bacteroides occured in peptic ulcer disorders.				[6]
Pneumonia  [ICD-11: CA40]
Description	Bacteroides sp. in the oropharyngeal microbiome was associated with pneumonia.				[5]
Ulcerative colitis  [ICD-11: DD71]
Description	The level of Bacteroides community decreased in ulcerative colitis.				[7]

Host Genetic Factors (HGFs)
NOD2
HGF ID	HGF2335	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	The deletion of NOD2 showed significantly increased abundance of Bacteroides sp. (p-value<0.05).				[8]
AMY1A
HGF ID	HGF2311	HGF Info	Class	Copy Number Variation: Gene Duplication (CNV-GDu)
Description	Gut microbiome Bacteroides differs between high AMY1-CN and low AMY1-CN groups at the OTU Level (p-value<0.05).				[9]
A2ML1
HGF ID	HGF2326	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	The duplication of A2ML1 could increase relative abundances of Bacteroides (p-value<0.05).				[10]
KLB
HGF ID	HGF2334	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	The deletion of KLB increased the proportion of Bacteroides.				[11]
TLR9
HGF ID	HGF2343	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	The deletion of TLR9 has been associated with the lower levels of Bacteroides.				[12]
VIPR2
HGF ID	HGF2350	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	The deletion of VIPR2 has been associated with the increased abundance of Bacteroides.				[13]
VDR
HGF ID	HGF2353	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	The percentage of abundance of Bacteroides significantly increased in VDR deletion mice (p-value<0.05).				[14]
ARNTL
HGF ID	HGF2325	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	The deletion of BMAL1 could increase relative abundances of Bacteroidales spp. (p-value<0.05).				[15]
KCNE2
HGF ID	HGF2341	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	The deletion of KCNE2 was significantly associated with the reduced relative abundance of the Bacteroidales (p-value<0.05).				[16]
SLC15A1
HGF ID	HGF2354	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	The deletion of PepT1 could decrease the abundance of Bacteroides.				[17]
NLRP3
HGF ID	HGF2355	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	The deletion of NLRP3 could significantly decrease the abundance of Bacteroides (p-value<0.001).				[18]
NLRP6
HGF ID	HGF2356	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	The deletion of Nlrp6 could decrease the abundance of Bacteroidaceae.				[19]
RAG2
HGF ID	HGF2357	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	The deletion of Rag2 could decrease the abundance of Bacteroidales.				[20]
hsa-miR-204-5p
HGF ID	HGF0207	HGF Info	Class	Non-coding RNA: Micro (ncRNA-miRNA)
Description	The expression of miR-204 was significantly regulated by Bacteroides (p-value<0.05).				[21]
rs984668
HGF ID	HGF2269	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs984668 SNP was significantly associated with the abundance of Bacteroides (p-value=1.98E-07).				[22]
rs7886938
HGF ID	HGF1632	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs7886938 SNP was significantly associated with the abundance of Bacteroides (p-value=5.45E-07).				[22]
rs7644
HGF ID	HGF1437	HGF Info	Class	Single Nucleotide Polymorphism: Prime UTR variant (SNP-PV)
Description	The rs7644 SNP was significantly associated with the abundance of Bacteroides (p-value=2.62E-06).				[22]
rs7634041
HGF ID	HGF2089	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs7634041 SNP was significantly associated with the abundance of Bacteroides (p-value=1.44E-06).				[22]
rs737301
HGF ID	HGF2299	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs737301 SNP was significantly associated with the abundance of Bacteroides (p-value=1.63E-06).				[22]
rs7296338
HGF ID	HGF2233	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs7296338 SNP was significantly associated with the abundance of Bacteroides (p-value=2.85E-07).				[22]
rs7258176
HGF ID	HGF1293	HGF Info	Class	Single Nucleotide Polymorphism: Synonymous variant (SNP-SV)
Description	The rs7258176 SNP was significantly associated with the abundance of Bacteroides (p-value=1.16E-05).				[22]
rs7139612
HGF ID	HGF1679	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs7139612 SNP was significantly associated with the abundance of Bacteroides (p-value=1.13E-05).				[22]
rs7106602
HGF ID	HGF1824	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs7106602 SNP was significantly associated with the abundance of Bacteroides (p-value=5.62E-06).				[22]
rs6536782
HGF ID	HGF1529	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs6536782 SNP was significantly associated with the abundance of Bacteroides (p-value=1.50E-05).				[22]
rs6466898
HGF ID	HGF2006	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs6466898 SNP was significantly associated with the abundance of Bacteroides (p-value=3.65E-06).				[22]
rs508259
HGF ID	HGF1475	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs508259 SNP was significantly associated with the abundance of Bacteroides (p-value=3.24E-08).				[22]
rs4986790
HGF ID	HGF1279	HGF Info	Class	Single Nucleotide Polymorphism: Missense variant (SNP-MV)
Description	A variant in TLR4 (rs4986790) was found to be associated with an increase in Bacteroides.				[23]
rs4901725
HGF ID	HGF2203	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs4901725 SNP was significantly associated with the abundance of Bacteroides (p-value=2.43E-08).				[22]
rs4777927
HGF ID	HGF1581	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs4777927 SNP was significantly associated with the abundance of Bacteroides (p-value=1.67E-08).				[22]
rs4747490
HGF ID	HGF2266	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs4747490 SNP was significantly associated with the abundance of Bacteroides (p-value=5.72E-06).				[22]
rs470497
HGF ID	HGF2158	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs470497 SNP was significantly associated with the abundance of Bacteroides (p-value=3.01E-06).				[22]
rs4628206
HGF ID	HGF1432	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs4628206 SNP was significantly associated with the abundance of Bacteroides (p-value=5.13E-08).				[22]
rs4468234
HGF ID	HGF1621	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs4468234 SNP was significantly associated with the abundance of Bacteroides (p-value=0.03809).				[24]
rs4463892
HGF ID	HGF2242	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs4463892 SNP was significantly associated with the abundance of Bacteroides (p-value=0.02738).				[24]
rs4360824
HGF ID	HGF2217	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs4360824 SNP was significantly associated with the abundance of Bacteroides (p-value=1.53E-06).				[22]
rs3950612
HGF ID	HGF1910	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs3950612 SNP was significantly associated with the abundance of Bacteroides (p-value=4.02E-07).				[22]
rs380915
HGF ID	HGF1612	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs380915 SNP was significantly associated with the abundance of Bacteroides (p-value=1.04E-06).				[22]
rs360402
HGF ID	HGF2090	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs360402 SNP was significantly associated with the abundance of Bacteroides (p-value=1.54E-06).				[22]
rs3105827
HGF ID	HGF2174	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs3105827 SNP was significantly associated with the abundance of Bacteroides (p-value=6.96E-06).				[22]
rs2997983
HGF ID	HGF1944	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs2997983 SNP was significantly associated with the abundance of Bacteroides (p-value=7.66E-07).				[22]
rs295569
HGF ID	HGF1483	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs295569 SNP was significantly associated with the abundance of Bacteroides (p-value=8.64E-06).				[22]
rs2866194
HGF ID	HGF2081	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs2866194 SNP was significantly associated with the abundance of Bacteroides (p-value=4.45E-08).				[22]
rs2704557
HGF ID	HGF2138	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs2704557 SNP was significantly associated with the abundance of Bacteroides (p-value=3.63E-07).				[22]
rs2282644
HGF ID	HGF1233	HGF Info	Class	Single Nucleotide Polymorphism: Synonymous variant (SNP-SV)
Description	The rs2282644 SNP was significantly associated with the abundance of Bacteroides (p-value=1.66E-07).				[22]
rs2228440
HGF ID	HGF1427	HGF Info	Class	Single Nucleotide Polymorphism: Synonymous variant (SNP-SV)
Description	The rs2228440 SNP was significantly associated with the abundance of Bacteroides (p-value=7.41E-06).				[22]
rs2228332
HGF ID	HGF1923	HGF Info	Class	Single Nucleotide Polymorphism: Missense variant (SNP-MV)
Description	The rs2228332 SNP was associated with the abundance of Bacteroides (p-value=1.19E-06).				[25]
rs2198863
HGF ID	HGF2040	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs2198863 SNP was associated with the abundance of Bacteroides (p-value=4.39E-07).				[22]
rs1948223
HGF ID	HGF1677	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs1948223 SNP was associated with the abundance of Bacteroides (p-value=8.26E-08).				[22]
rs193591
HGF ID	HGF1313	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs193591 SNP was associated with the abundance of Bacteroides (p-value=0.03118).				[24]
rs1918707
HGF ID	HGF2243	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs1918707 SNP was associated with the abundance of Bacteroides (p-value=8.29E-07).				[22]
rs17506987
HGF ID	HGF2077	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs17506987 SNP was associated with the abundance of Bacteroides (p-value=5.26E-07).				[22]
rs16948999
HGF ID	HGF1520	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs16948999 SNP was associated with the abundance of Bacteroides (p-value=5.29E-06).				[22]
rs159373
HGF ID	HGF1484	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs159373 SNP was associated with the abundance of Bacteroides (p-value=1.67E-07).				[22]
rs151216
HGF ID	HGF1696	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs151216 SNP was associated with the abundance of Bacteroides (p-value=1.08E-06).				[22]
rs1508541
HGF ID	HGF1866	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs1508541 SNP was associated with the abundance of Bacteroides (p-value=0.01724).				[24]
rs1489848
HGF ID	HGF1377	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs1489848 SNP was associated with the abundance of Bacteroides (p-value=5.39E-07).				[22]
rs13067391
HGF ID	HGF1546	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs13067391 SNP was associated with the abundance of Bacteroides (p-value=1.21E-07).				[22]
rs12936861
HGF ID	HGF1819	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs12936861 SNP was associated with the abundance of Bacteroides (p-value=3.87E-07).				[22]
rs11868220
HGF ID	HGF2173	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs11868220 SNP was associated with the abundance of Bacteroides (p-value=3.16E-06).				[22]
rs11701867
HGF ID	HGF1245	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs11701867 SNP was associated with the abundance of Bacteroides (p-value=1.84E-07).				[22]
rs11073804
HGF ID	HGF2190	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs11073804 SNP was associated with the abundance of Bacteroides (p-value=6.06E-06).				[22]
rs10928081
HGF ID	HGF1542	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs10928081 SNP was associated with the abundance of Bacteroides (p-value=5.12E-07).				[22]
rs10801316
HGF ID	HGF2294	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs10801316 SNP was associated with the abundance of Bacteroides (p-value=4.73E-07).				[22]
rs10507725
HGF ID	HGF2216	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs10507725 SNP was associated with the abundance of Bacteroides (p-value=4.71E-08).				[22]
rs10501839
HGF ID	HGF1532	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs10501839 SNP was associated with the abundance of Bacteroides (p-value=9.96E-07).				[22]
rs10488566
HGF ID	HGF1995	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs10488566 SNP was associated with the abundance of Bacteroides (p-value=1.49E-05).				[22]
rs10114968
HGF ID	HGF1895	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs10114968 SNP was associated with the abundance of Bacteroides (p-value=1.44E-06).				[22]
rs571312
HGF ID	HGF2159	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The variant gene MC4R of innate immunity rs571312 is significantly associated with the abundance of gut micriobiota Bacteroidaceae (p-value=0.0010).				[26]
rs11739663
HGF ID	HGF2527	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs11739663 SNP is associated with the abundance of Bacteroides.				[27]
rs921720
HGF ID	HGF2528	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-UV)
Description	The rs921720 SNP is associated with the abundance of Bacteroides.				[27]
rs1819333
HGF ID	HGF2529	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs1819333 SNP is associated with the abundance of Bacteroides.				[27]
rs10061469
HGF ID	HGF2530	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs10061469 SNP is associated with the abundance of Bacteroides.				[27]
rs7517810
HGF ID	HGF2531	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs7517810 SNP is associated with the abundance of Bacteroides.				[27]
rs6920220
HGF ID	HGF2532	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs6920220 SNP is associated with the abundance of Bacteroides.				[27]
rs12568930
HGF ID	HGF2533	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs12568930 SNP is associated with the abundance of Bacteroides.				[27]
rs26971743
HGF ID	HGF2534	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs26971743 SNP is associated with the heritable variation in Bacteroides abundance.				[28]
rs6314621
HGF ID	HGF2535	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs6314621 SNP is associated with the heritable variation in Bacteroides abundance.				[28]
rs26972849
HGF ID	HGF2536	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs26972849 SNP is associated with the heritable variation in Bacteroides abundance.				[28]

Host Immune Factors (HIFs)
C-C motif chemokine 13
HIF ID	HIFM0018	HIF Info	Class	Antimicrobial peptide (AMP)
Description	The order of Bacteroidales abundance was correlated with expression of CCL13.				[29]
HD-5(1-9)
HIF ID	HIFM0289	HIF Info	Class	Antimicrobial peptide (AMP)
Description	HD-519 treatment could decrease the ralative abundance of the genera Bacteroides.				[30]
Perforin
HIF ID	HIFM0320	HIF Info	Class	Antimicrobial peptide (AMP)
Description	The most abundant and stable members of the gut microbiota, Bacteroides spp.produce membrane attack complex/perforin (MACPF) domain pore-forming toxins.				[31]
T-lymphocyte activation antigen CD86
HIF ID	HIFM0055	HIF Info	Class	Checkpoint molecule (CM)
Description	The proportions of cells expressing the co-receptors CD86 was associated with the abundance of Bacteroidales.				[32]
Programmed Cell Death 1 Protein
HIF ID	HIFM0191	HIF Info	Class	Checkpoint molecule (CM)
Description	The relative abudance of the Bacteroide sp.is effected by PD-1 antibody treatment.				[33]
T-cell immunoreceptor with Ig and ITIM domains
HIF ID	HIFM0214	HIF Info	Class	Checkpoint molecule (CM)
Description	The expression of co-receptors TIGIT was associated with Bacteroidales.				[32]
Tumor necrosis factor receptor superfamily member 4
HIF ID	HIFM0231	HIF Info	Class	Checkpoint molecule (CM)
Description	The proportions of cells expressing the co-receptors OX40 was associated with Bacteroidales.				[34]
Tumor necrosis factor receptor superfamily member 9
HIF ID	HIFM0233	HIF Info	Class	Checkpoint molecule (CM)
Description	The abundance of Bacteroides is associated with 4-1BB.				[35]
Tumor necrosis factor receptor superfamily member 5
HIF ID	HIFM0232	HIF Info	Class	Checkpoint molecule (CM)
Description	The proportions of cells expressing the co-receptors CD86 was associated with Bacteroidales.				[32]
Interferon-2
HIF ID	HIFM0141	HIF Info	Class	Cytokine (Cyt)
Description	Bacteroidaceae is associated with IL-2 expression.				[36]
Interferon-6
HIF ID	HIFM0151	HIF Info	Class	Cytokine (Cyt)
Description	Bacteroidaceae is associated with IL-6 expression.				[36]
Tumor necrosis factor
HIF ID	HIFM0226	HIF Info	Class	Cytokine (Cyt)
Description	The abundance of Bacteroidaceae was associated with the level of TNF-Alpha.				[36]
Interferon gamma
HIF ID	HIFM0260	HIF Info	Class	Cytokine (Cyt)
Description	The abundance of Bacteroidaceae was associated with the level of IFN-Gamma.				[36]
Immunoglobulin E
HIF ID	HIFM0271	HIF Info	Class	Immunoglobulin (Ig)
Description	Bacteroidales consortium could suppress IgE binding to the fecal bacteria of treated FA Il4raF709 mice.				[37]
Immunoglobulin A
HIF ID	HIFM0272	HIF Info	Class	Immunoglobulin (Ig)
Description	Bacteroides was significantly enriched in the IgA(Low or no IgA binding) consortia.				[38]
Immunoglobulin A2
HIF ID	HIFM0276	HIF Info	Class	Immunoglobulin (Ig)
Description	Bacteroides could be preferentially recognized by IgA2 in the stool samples.				[39]
CD16+ Natural Killer cells
HIF ID	HIFC0094	HIF Info	Class	Natural killer cells (NKCs)
Description	The increased proportion of CD16+ NK cells was associated with the decrease of gut commensal bacteria(Bacteroides).				[40]
Retinoic acid-related orphan receptor t
HIF ID	HIFM0248	HIF Info	Class	Retinoic acid receptor (RAR)
Description	Commensals of the order Clostridiales and Bacteroidales drive the differentiation of induced Treg (iTreg) cells expressing the transcription factor RORGammat.				[41]
Myeloid differentiation primary response 88 signaling pathway
HIF ID	HIFP0026	HIF Info	Class	Signaling pathway (SP)
Description	Clostridiales and Bacteroidales orders act to induce the transcription factor RORGammat in nascent Treg cells via an upstream MyD88-dependent mechanism to promote tolerance to dietary antigens.				[41]
Regulatory T cells
HIF ID	HIFC0030	HIF Info	Class	T cells (TCs)
Description	Bacteroidales induced the transcription factor RORt in nascent Treg cells.				[41]
RORt+ regulatory T cells
HIF ID	HIFC0038	HIF Info	Class	T cells (TCs)
Description	Bacteroidales plays an important role in nascent Treg cells that gives rise to disease-suppressing ROR-t+ Treg cells.				[37]
CD3+CD4+ T cells
HIF ID	HIFC0065	HIF Info	Class	T cells (TCs)
Description	Enterotoxigenic Bacteroides fragilis can rapidly induce infiltration of the colonic lamina propria with IL-17-producing CD3+CD4+ T-cells.				[42]
CD3+CD4+ T cells
HIF ID	HIFC0066	HIF Info	Class	T cells (TCs)
Description	Enterotoxigenic Bacteroides fragilis can rapidly induce infiltration of the colonic lamina propria with IL-17-producing CD3+CD4 GammaDelte-T-cells.				[42]
Foxp3+CD45RA regulatory T cells
HIF ID	HIFC0184	HIF Info	Class	T cells (TCs)
Description	The abundance of Bacteroides increased in the patients with clearly high distribution of FOXp3highCD45RA Tregs.				[43]
T-cell surface glycoprotein CD4
HIF ID	HIFM0050	HIF Info	Class	T-cell receptor (TCR)
Description	The stool of HIV-infected patients with high CD4 counts were enriched for traditional gastrointestinal genera Bacteroides(false discovery rate q < 0.05, read difference 100 reads, and presence in 50%).				[44]

Environmental Factor(s)
Disbiome ID			36
gutMDisorder ID			gm0077

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