Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0232)
HIF Name
Tumor necrosis factor receptor superfamily member 5
HIF Synonym(s)
CTLA4, CD40
HIF Classification
Checkpoint molecule (CM)
Molecular Function
Receptor
Description CD40 is reported to be crucial immune modulator. [1]
Pfam TNFR/NGFR cysteine-rich region (PF00020 )
Pathway Allograft rejection (hsa05330 )
Asthma (hsa05310 )
Autoimmune thyroid disease (hsa05320 )
Cell adhesion molecules (CAMs) (hsa04514 )
Cytokine-cytokine receptor interaction (hsa04060 )
Epstein-Barr virus infection (hsa05169 )
Human T-cell leukemia virus 1 infection (hsa05166 )
Intestinal immune network for IgA production (hsa04672 )
Malaria (hsa05144 )
NF-kappa B signaling pathway (hsa04064 )
Primary immunodeficiency (hsa05340 )
Systemic lupus erythematosus (hsa05322 )
Toll-like receptor signaling pathway (hsa04620 )
Toxoplasmosis (hsa05145 )
Transcriptional misregulation in cancer (hsa05202 )
Viral myocarditis (hsa05416 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
TNR5_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Bacteroides sp. (CFB bacteria) MIC00176
             Description The proportions of cells expressing the co-receptors CD86 was associated with Bacteroidales. [2]
         Listeria monocytogenes (firmicutes) MIC00771
             Description Listeria monocytogenes is a food-borne intracellular bacterium that causes listeriosis to 1.600 people each year, being responsible of approximately 260 deaths.This pathogen mostly affects immunocompromised individuals and pregnant women. [3]
References
1 Exploration of a novel prognostic risk signatures and immune checkpoint molecules in endometrial carcinoma microenvironment.Genomics. 2020 Sep;112(5):3117-3134. doi: 10.1016/j.ygeno.2020.05.022. Epub 2020 May 29.
2 Exopolysaccharide Produced by Lactobacillus Plantarum Induces Maturation of Dendritic Cells in BALB/c Mice.PLoS One. 2015 Nov 24;10(11):e0143743. doi: 10.1371/journal.pone.0143743. eCollection 2015.
3 HDAC6 controls innate immune and autophagy responses to TLR-mediated signalling by the intracellular bacteria Listeria monocytogenes. PLoS Pathog. 2017 Dec 27;13(12):e1006799. doi: 10.1371/journal.ppat.1006799. eCollection 2017 Dec.

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