Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00771)
MIC Name Listeria monocytogenes (firmicutes)
MIC Synonyms Bacterium monocytogenes
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Bacillales
Family: Listeriaceae
Genus: Listeria
Species: Listeria monocytogenes
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Respiratory or Fermentative
Gram Positive
Host Relationship Pathogen
Genome Size (bp) 2894716
No. of Coding Genes 3131
No. of Non-Coding Genes 85
No. of Small Non-Coding Genes 85
No. of Gene Transcripts 3216
No. of Base Pairs 2776517
Description Listeria monocytogenes is a pathogenic bacterium that causes the infection listeriosis. It is a facultative anaerobic bacterium, capable of surviving in the presence or absence of oxygen.
External Links Taxonomy ID
1639
Genome Assembly ID
ASM38292v1
GOLD Organism ID
Go0075365
Disease Relevance
          Inflammatory bowel disease  [ICD-11: DD72]
             Description Listeria monocytogenes has been linked to the development and exacerbation of inflammatory bowel disease. [1]
Host Genetic Factors (HGFs)
          CD44
             HGF ID HGF2333 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description Listeria monocytogenes had a significant difference in the percentage abundance between the EAE-induced CD44 wide type and the CD44 knock out mice (p-value<0.05). [2]
          NOD2
             HGF ID HGF2335 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of NOD2 has been associated with the increased amount of Listeria. [3]
          hsa-let-7a-1
             HGF ID HGF0588 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of let-7a1 expression showed significantly downregulated upon Listeria monocytogenes infection (p-value<0.05). [4]
          hsa-miR-146b-5p
             HGF ID HGF0251 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-146b expression showed significantly upregulated upon Listeria monocytogenes infection (p-value<0.05). [4]
          hsa-miR-148a-3p
             HGF ID HGF0249 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-146b expression showed significantly downregulated upon Listeria monocytogenes infection (p-value<0.05). [4]
          hsa-miR-143-3p
             HGF ID HGF0258 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-143 expression was significantly downregulated in the intestines of mice infected with Listeria monocytogenes (p-value<0.05). [5]
          hsa-miR-200b-3p
             HGF ID HGF0212 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-200b expression was significantly downregulated in the intestines of mice infected with Listeria monocytogenes (p-value<0.05). [5]
          hsa-miR-200c-3p
             HGF ID HGF0210 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-200c expression was significantly downregulated in the intestines of mice infected with Listeria monocytogenes (p-value<0.05). [5]
          hsa-miR-378a-3p
             HGF ID HGF0134 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-378 expression was significantly downregulated in the intestines of mice infected with Listeria monocytogenes (p-value<0.05). [5]
          mmu-miR-455
             HGF ID HGF2369 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The mmu-miR-455 expression was up-regulated 3.2-fold in Listeria monocytogenes infection. [6]
          hsa-miR-998
             HGF ID HGF0702 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of hsa-miR-998 expression was significantly down-regulated with infection of Listeria monocytogenes (p-value<0.05). [7]
          hsa-miR-954
             HGF ID HGF0701 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of hsa-miR-954 expression was significantly up-regulated with infection of Listeria monocytogenes (p-value<0.05). [7]
          hsa-miR-3000
             HGF ID HGF0665 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of hsa-miR-3000 expression was significantly up-regulated with infection of Listeria monocytogenes (p-value<0.05). [7]
          mmu-miR-29b
             HGF ID HGF2370 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The mmu-miR-29b expression was up-regulated 2.9-fold in Listeria monocytogenes infection. [6]
          hsa-miR-215-5p
             HGF ID HGF0661 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-215 expression was repressed during Listeria monocytogenes infection. [8]
          hsa-miR-133a-5p
             HGF ID HGF0643 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-133 expression was significantly up-regulated with infection of Listeria monocytogenes (p-value<0.05). [7]
          mmu-miR-125a-3p
             HGF ID HGF2371 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The mmu-miR-125a-3p expression was up-regulated 5.3-fold in Listeria monocytogenes infection. [6]
          mmu-miR-125a-5p
             HGF ID HGF2372 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The mmu-miR-125a-5p expression was up-regulated 1.7-fold in Listeria monocytogenes infection. [6]
          mmu-miR-132
             HGF ID HGF2373 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The mmu-miR-132 expression was up-regulated 1.5-fold in Listeria monocytogenes infection. [6]
          mmu-miR-139-5p
             HGF ID HGF2374 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The mmu-miR-139 expression was up-regulated 1.8-fold in Listeria monocytogenes infection. [6]
          hsa-miR-145-5p
             HGF ID HGF0254 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-145-5p may mediate the proinflammatory responses of host immune responses to Listeria monocytogenes infection. [9]
          hsa-miR-146a-5p
             HGF ID HGF0252 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The mmu-miR-146a expression was up-regulated 2.5-fold in Listeria monocytogenes infection. [6]
          mmu-miR-147
             HGF ID HGF2375 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The mmu-miR-147 expression was up-regulated 3.1-fold in Listeria monocytogenes infection. [6]
          hsa-miR-149-5p
             HGF ID HGF0247 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The mmu-miR-149 expression was up-regulated 2-fold in Listeria monocytogenes infection. [6]
          hsa-miR-155-5p
             HGF ID HGF0243 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-155-5p may mediate the proinflammatory responses of host immune responses to Listeria monocytogenes infection. [9]
          hsa-miR-16-5p
             HGF ID HGF0240 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-16-5p may mediate the proinflammatory responses of host immune responses to Listeria monocytogenes infection. [9]
          hsa-miR-191-5p
             HGF ID HGF0225 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The mmu-miR-191 expression was up-regulated 1.7-fold in Listeria monocytogenes infection. [6]
          hsa-miR-192-5p
             HGF ID HGF0224 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-192 expression was repressed by Listeria monocytogenes infection. [8]
          hsa-miR-194-5p
             HGF ID HGF0222 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-194 expression decreased slightly upon Listeria infection. [10]
          hsa-miR-29a-3p
             HGF ID HGF0178 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-29 expression was significantly downregulated by Listeria monocytogenes (p-value<0.05). [11]
          hsa-miR-29b-3p
             HGF ID HGF0177 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of hsa-miR-29b-3p was significantly down-regulated by Listeria monocytogenes pathogensa infection (p-value<0.05). [4]
          hsa-miR-30d-5p
             HGF ID HGF0165 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-30d was one of the most highly expressed miRNAs in Listeria monocytogenes infection. [10]
          mmu-miR-497
             HGF ID HGF2376 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The mmu-miR-497 expression was up-regulated 2.2-fold in Listeria monocytogenes infection. [6]
          hsa-miR-181b-5p
             HGF ID HGF0236 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The treatment with Lactobacillus leads to a lower expression of miR-181b. [8]
          hsa-miR-125a-5p
             HGF ID HGF0279 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-125a-5p expressipon was significantly upregulated with Listeria monocytogenes infection (p-value<0.05). [4]
Host Immune Factors (HIFs)
          Angiogenin-4
             HIF ID HIFM0005 HIF Info       Class Antimicrobial peptide (AMP)
             Description The number of colony forming units (CFU) of log-phase Listeria monocytogenes(Gram-positive pathogens) declined by>99% after a 2 h exposure to 1 M of Ang4. [12]
          Cathelicidin antimicrobial peptide
             HIF ID HIFM0014 HIF Info       Class Antimicrobial peptide (AMP)
             Description Several AMPs such as LL-37 exerts potent antimicrobial enzymatic activity against Listeria monocytogenes. [13]
          Regenerating islet-derived protein 3-gamma
             HIF ID HIFM0198 HIF Info       Class Antimicrobial peptide (AMP)
             Description Innate upregulation of RegIII gamma in intestinal epithelium conferred protection against Listeria monocytogenes infection. [14]
          Human lactoferricin
             HIF ID HIFM0237 HIF Info       Class Antimicrobial peptide (AMP)
             Description Lactoferricin has shown antibacterial activity against enterotoxigenic Listeria monocytogenes. [15]
          B cells
             HIF ID HIFC0001 HIF Info       Class B cells (BCs)
             Description Relative abundances of Listeria monocytogenes is associated with B cells response. [16]
          T-cell surface glycoprotein CD1b
             HIF ID HIFM0039 HIF Info       Class Checkpoint molecule (CM)
             Description CD1b dextramers loaded with natural PG from Listeria monocytogenes. [17]
          Tumor necrosis factor ligand superfamily member 7
             HIF ID HIFM0053 HIF Info       Class Checkpoint molecule (CM)
             Description Blockade of CD70 costimulation abrogated the mucosal T cell expansion and effector functions after oral Listeria monocytogenes infection. [18]
          T-lymphocyte activation antigen CD80
             HIF ID HIFM0054 HIF Info       Class Checkpoint molecule (CM)
             Description CD80 controls innate immune and autophagy responses to TLR-mediated signalling by the intracellular bacteria Listeria monocytogenes. [16]
          T-lymphocyte activation antigen CD86
             HIF ID HIFM0055 HIF Info       Class Checkpoint molecule (CM)
             Description Listeria monocytogenes is associated with CD86 expression. [16]
          CEA cell adhesion molecule 1
             HIF ID HIFM0057 HIF Info       Class Checkpoint molecule (CM)
             Description The predominance of the CEACAM1-S isoform requires persistent exposure to mucosal antigens such as Listeria monocytogenes. [19]
          Tumor necrosis factor ligand superfamily member 15
             HIF ID HIFM0224 HIF Info       Class Checkpoint molecule (CM)
             Description Listeria monocytogenes could activate TL1A expression in human APC, including monocytes and monocyte-derived DC. [20]
          Tumor necrosis factor receptor superfamily member 5
             HIF ID HIFM0232 HIF Info       Class Checkpoint molecule (CM)
             Description Listeria monocytogenes is a food-borne intracellular bacterium that causes listeriosis to 1.600 people each year, being responsible of approximately 260 deaths.This pathogen mostly affects immunocompromised individuals and pregnant women. [16]
          C-C motif chemokine 2
             HIF ID HIFM0022 HIF Info       Class Cytokine (Cyt)
             Description Listeria monocytogenes is associated with the MCP-1 expression. [16]
          C-C motif chemokine 20
             HIF ID HIFM0023 HIF Info       Class Cytokine (Cyt)
             Description During intestinal infection by Listeria monocytogenes, the production of CCL20 was increased. [21]
          Macrophage colony-stimulating factor 1
             HIF ID HIFM0065 HIF Info       Class Cytokine (Cyt)
             Description Listeria monocytogenes is associated with the CSF-1 production. [16]
          Interferon beta
             HIF ID HIFM0126 HIF Info       Class Cytokine (Cyt)
             Description The IFN-beta levels were lower with a weakened activation response to Listeria monocytogenes infection in Hdac6-deficient dendritic cells. [16]
          Interferon-10
             HIF ID HIFM0128 HIF Info       Class Cytokine (Cyt)
             Description The IL-10 levels were lower with a weakened activation response to Listeria monocytogenes infection in Hdac6-deficient dendritic cells. [16]
          Interferon-12 subunit alpha
             HIF ID HIFM0130 HIF Info       Class Cytokine (Cyt)
             Description Listeria monocytogenes induced the production of IL-12 expression. [16]
          Interleukin-1 beta
             HIF ID HIFM0138 HIF Info       Class Cytokine (Cyt)
             Description Listeria monocytogenes is associated with IL-1beta expression. [16]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Listeria monocytogenes is associated with IL-6 expression. [16]
          Interferon regulatory factor 3
             HIF ID HIFM0157 HIF Info       Class Cytokine (Cyt)
             Description Listeria monocytogenes is associated with IRF3 expression. [16]
          Transforming growth factor beta-2 proprotein
             HIF ID HIFM0213 HIF Info       Class Cytokine (Cyt)
             Description Listeria monocytogenes is associated with TGF-Beta concentrations. [16]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description Lack of HDAC6 also decreased the relative mRNA levels of the pro-inflammatory cytokines TNFalpha, IL-1beta and IL12p40, indicating impaired cytokine activation after Listeria monocytogenes infection. [16]
          Interferon gamma
             HIF ID HIFM0260 HIF Info       Class Cytokine (Cyt)
             Description At the species level, Listeria monocytogenes is associated with IFNGamma. [16]
          Interferon-1
             HIF ID HIFM0262 HIF Info       Class Cytokine (Cyt)
             Description At the species level, Listeria monocytogenes is associated with type I interferons. [16]
          Dendritic cells
             HIF ID HIFC0003 HIF Info       Class Dendritic cells (DCs)
             Description Early control of Listeria monocytogenes largely depends on the innate immune response occurring in the spleen, which relies on two main cell populations of dendritic cells (DCs). [16]
          Polymorphonuclear leukocytes
             HIF ID HIFC0017 HIF Info       Class Granulocytes (Gra)
             Description Opsonized regular-sized Listeria monocytogenes grown on blood agar elicited the greatest respiratory burst response and survived best in human polymorphonuclear leukocytes. [22]
          Neutrophils
             HIF ID HIFC0029 HIF Info       Class Granulocytes (Gra)
             Description Listeria monocytogenes is associated with Neutrophils responses. [16]
          Immunoglobulin D
             HIF ID HIFM0277 HIF Info       Class Immunoglobulin (Ig)
             Description The abundance of Listeria monocytogenes is associated with IgD. [23]
          Macrophages
             HIF ID HIFC0020 HIF Info       Class Macrophages (Mac)
             Description Activated macrophage can handle and directly kill Listeria monocytogenes. [16]
          Monocytes
             HIF ID HIFC0024 HIF Info       Class Monocytes (Mono)
             Description Recruitment of monocytes is essential for effective control and clearance of Listeria monocytogenes. [24]
          Ly6C+ monocytes
             HIF ID HIFC0207 HIF Info       Class Monocytes (Mono)
             Description Listeria monocytogenes infection could recruite Ly6C+ monocytes and regulate its abundance. [25]
          CD14+ CD16+ monocytes
             HIF ID HIFC0209 HIF Info       Class Monocytes (Mono)
             Description CD14+CD16+ monocytes could immigrate into sites of Listeria monocytogenes infection in the spleen in the absence of CCL2 action. [26]
          Natural Killer cells
             HIF ID HIFC0028 HIF Info       Class Natural killer cells (NKCs)
             Description Listeria monocytogenes is associated with NK cell responses. [16]
          NACHT, LRR and PYD domains-containing protein 3
             HIF ID HIFM0180 HIF Info       Class Nod-like receptor (NLR)
             Description Listeria monocytogenes is associated with NALP3 activation. [16]
          Nucleotide-binding oligomerization domain-containing protein 2
             HIF ID HIFM0185 HIF Info       Class Nod-like receptor (NLR)
             Description Listeria monocytogenes is associated with NOD2 activation. [16]
          Mitogen-activated protein kinase signaling pathway
             HIF ID HIFP0023 HIF Info       Class Signaling pathway (SP)
             Description Listeria monocytogenes infection could active MAPK. [16]
          Nuclear factor kappa B signaling pathway
             HIF ID HIFP0028 HIF Info       Class Signaling pathway (SP)
             Description Listeria monocytogenes is associated with NF-B induction. [16]
          Toll like receptor signaling pathway
             HIF ID HIFP0043 HIF Info       Class Signaling pathway (SP)
             Description The response of dendritic cells (DC) to live Listeria monocytogenes is mediated by toll-like receptors (TLRs). [16]
          CD4+CD25+ regulatory T cells
             HIF ID HIFC0035 HIF Info       Class T cells (TCs)
             Description Listeria monocytogenes is associated with CD4+CD25+T cells responses. [16]
          CD4+ T cells
             HIF ID HIFC0069 HIF Info       Class T cells (TCs)
             Description Listeria monocytogenes is associated with CD4 T cells responses. [16]
          CD8+ T cells
             HIF ID HIFC0073 HIF Info       Class T cells (TCs)
             Description A specific CD8 T cell response was developed by the host cell in response to cytosolic Listeria monocytogenes, which is crucial for the control of infection. [16]
          Gammadelta+ T cells
             HIF ID HIFC0077 HIF Info       Class T cells (TCs)
             Description Listeria monocytogenes is associated with GammaDelte T cells responses. [16]
          T helper type 1 cells
             HIF ID HIFC0082 HIF Info       Class T cells (TCs)
             Description Listeria monocytogenes-specific T cells were shown to differentiate into T helper type 1(Th1)cells. [27]
          T-cell-specific surface glycoprotein CD28
             HIF ID HIFM0046 HIF Info       Class T-cell receptor (TCR)
             Description The lack of CD28 is associated with elevated bacterial loads at initial times post Listeria monocytogenes infection. [28]
          Toll-like receptor 2
             HIF ID HIFM0217 HIF Info       Class Toll-like receptor (TLR)
             Description Listeria monocytogenes is associated with TLR2 expression. [16]
Environmental Factor(s)
             Disbiome ID
      268
             gutMDisorder ID
      gm0425
             aBiofilm Organism
      Listeria monocytogenes
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15 Not Avaliable
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