General Information of HIF (ID: HIFC0209)
HIF Name	CD14+ CD16+ monocytes
HIF Synonym(s)	CD14+ CD16+ monocytes
HIF Classification	Monocytes (Mono)
Description	CD14+ CD16+ monocytes is a type of the immune cells.				[1]

Microbe Species (MIC) Regulated by This HIF
Bifidobacterium sp. (actinobacteria)			MIC00224
Description	The increase in numbers of Bifidobacterium was negatively correlated with CCR2 and CX3CR1 expressions on CD14+CD16+ monocytes.				[2]
Escherichia coli (enterobacteria)			MIC00516
Description	CD14+CD16+ monocytes increased in children with hemolytic uremic syndrome caused by infection with Shiga toxin-producing Escherichia coli bacteria.				[3]
Human immunodeficiency virus 1 (viruses)			MIC02009
Description	CD14+CD16+ monocytes were associated with the expression of Human immunodeficiency virus-1(HIV).				[4]
Listeria monocytogenes (firmicutes)			MIC00771
Description	CD14+CD16+ monocytes could immigrate into sites of Listeria monocytogenes infection in the spleen in the absence of CCL2 action.				[3]
Plasmodium vivax (apicomplexans)			MIC01998
Description	CD14+CD16+ monocytes expanded in a group of Plasmodium vivax-infected patients.				[5]
Streptococcus sp. (firmicutes)			MIC01276
Description	CD14+CD16+ monocytes response were associated with the abundance of streptococci.				[3]
Zika virus (viruses)			MIC01997
Description	CD14+CD16+ monocytes were the main target of Zika virus infection in peripheral blood mononuclear cells in a paediatric study in Nicaragua.				[6]

References
1	A Protocol for the Comprehensive Flow Cytometric Analysis of Immune Cells in Normal and Inflamed Murine Non-Lymphoid Tissues.PLoS One. 2016 Mar 3;11(3):e0150606. doi: 10.1371/journal.pone.0150606. eCollection 2016.
2	Change in gut microbiota is correlated with alterations in the surface molecule expression of monocytes after Roux-en-Y gastric bypass surgery in obese type 2 diabetic patients. Am J Transl Res. 2017 Mar 15;9(3):1243-1254. eCollection 2017.
3	The CD14+ CD16+ blood monocytes: their role in infection and inflammation.J Leukoc Biol. 2007 Mar;81(3):584-92. doi: 10.1189/jlb.0806510. Epub 2006 Nov 29.
4	Dopamine Increases CD14(+)CD16(+) Monocyte Transmigration across the Blood Brain Barrier: Implications for Substance Abuse and HIV Neuropathogenesis.J Neuroimmune Pharmacol. 2017 Jun;12(2):353-370. doi: 10.1007/s11481-017-9726-9. Epub 2017 Jan 29.
5	The CD14+CD16+ inflammatory monocyte subset displays increased mitochondrial activity and effector function during acute Plasmodium vivax malaria.PLoS Pathog. 2014 Sep 18;10(9):e1004393. doi: 10.1371/journal.ppat.1004393. eCollection 2014 Sep.
6	CD14(+)CD16(+) monocytes are the main target of Zika virus infection in peripheral blood mononuclear cells in a paediatric study in Nicaragua.Nat Microbiol. 2017 Nov;2(11):1462-1470. doi: 10.1038/s41564-017-0035-0. Epub 2017 Oct 2.

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