General Information of MIC (ID: MIC02009)
MIC Name	Human immunodeficiency virus 1 (viruses)
MIC Synonyms	HIV-1
Body Site	Oral Cavity
Lineage	Kingdom: Viruses Phylum: Artverviricota Class: Revtraviricetes Order: Ortervirales Family: Retroviridae Genus: Lentivirus Species: Human immunodeficiency virus 1
Host Relationship	Pathogen
Description	Human immunodeficiency virus-1 (HIV-1) is a lentivirus that causes acquired immunodeficiency syndromes.
External Links	Taxonomy ID	11676
	Genome Assembly ID	ASM309785v1
	GOLD Organism ID	Go0076358

Host Immune Factors (HIFs)
IgG plasma B cell
HIF ID	HIFC0219	HIF Info	Class	B cells (BCs)
Description	Increased IgG plasma cell was associated with high pH1N1 hemagglutination inhibition responses to the expression of HIV.				[1]
CD14+ CD16+ monocytes
HIF ID	HIFC0209	HIF Info	Class	Monocytes (Mono)
Description	CD14+CD16+ monocytes were associated with the expression of Human immunodeficiency virus-1(HIV).				[2]
CD16 + monocytes
HIF ID	HIFC0118	HIF Info	Class	Monocytes (Mono)
Description	CD16+ monocytes are infected by HIV in peripheral blood and transport virus into thethe central nervous system.				[3]
CD8+ T cells
HIF ID	HIFC0073	HIF Info	Class	T cells (TCs)
Description	CD8+ T cell responses was controlled by Treg cells against HIV.				[4]
FOXP3+CD127lo CD4+ T cells
HIF ID	HIFC0084	HIF Info	Class	T cells (TCs)
Description	FOXP3+CD127lo CD4+ T cells may reduce the levels of T cell activation following primary HIV-infection.				[5]

References
1	Characterization of functional antibody and memory B-cell responses to pH1N1 monovalent vaccine in HIV-infected children and youth.PLoS One. 2015 Mar 18;10(3):e0118567. doi: 10.1371/journal.pone.0118567. eCollection 2015.
2	Dopamine Increases CD14(+)CD16(+) Monocyte Transmigration across the Blood Brain Barrier: Implications for Substance Abuse and HIV Neuropathogenesis.J Neuroimmune Pharmacol. 2017 Jun;12(2):353-370. doi: 10.1007/s11481-017-9726-9. Epub 2017 Jan 29.
3	Expression of CD14, CD16 and CD45RA on monocytes from periodontitis patients.J Periodontal Res. 2004 Feb;39(1):72-8. doi: 10.1111/j.1600-0765.2004.00713.x.
4	Regulatory T cells in retroviral infections.PLoS Pathog. 2018 Feb 15;14(2):e1006776. doi: 10.1371/journal.ppat.1006776. eCollection 2018 Feb.
5	FOXP3 expressing CD127lo CD4+ T cells inversely correlate with CD38+ CD8+ T cell activation levels in primary HIV-1 infection.J Leukoc Biol. 2008 Feb;83(2):254-62. doi: 10.1189/jlb.0507281. Epub 2007 Nov 2.

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