General Information of HIF (ID: HIFC0118)
HIF Name	CD16 + monocytes
HIF Synonym(s)	CD16+ monocytes, CD16 + monocytes
HIF Classification	Monocytes (Mono)
Description	Classical CD16(-) vs intermediate/ nonclassical CD16(+) monocytes differ in their homing potential and biological functions.				[1]

Microbe Species (MIC) Regulated by This HIF
Aggregatibacter actinomycetemcomitans (gamma-proteobacteria)			MIC00051
Description	CD16+ monocytes produced IL-6 in response to lipopolysaccharide from Actinobacillus actinomycetemcomitans.				[2]
Dengue virus (viruses)			MIC02008
Description	CD16+ monocytes response were associated with dengue virus.				[3]
Escherichia coli (enterobacteria)			MIC00516
Description	CD16+ monocytes expressed IL-6 in response to stimulation with LPS from Escherichia coli, and more than 80% of CD16+ monocytes expressed cytoplasmic IL-6.				[2]
Human immunodeficiency virus 1 (viruses)			MIC02009
Description	CD16+ monocytes are infected by HIV in peripheral blood and transport virus into thethe central nervous system.				[2]

References
1	CD16(+) monocytes give rise to CD103(+)RALDH2(+)TCF4(+) dendritic cells with unique transcriptional and immunological features.Blood Adv. 2018 Nov 13;2(21):2862-2878. doi: 10.1182/bloodadvances.2018020123.
2	Expression of CD14, CD16 and CD45RA on monocytes from periodontitis patients.J Periodontal Res. 2004 Feb;39(1):72-8. doi: 10.1111/j.1600-0765.2004.00713.x.
3	A Novel, Five-Marker Alternative to CD16-CD14 Gating to Identify the Three Human Monocyte Subsets.Front Immunol. 2019 Jul 26;10:1761. doi: 10.3389/fimmu.2019.01761. eCollection 2019.

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