Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00051)
MIC Name Aggregatibacter actinomycetemcomitans (gamma-proteobacteria)
MIC Synonyms Actinobacillus actinomycetemcomitans
Body Site Oral Cavity
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Pasteurellales
Family: Pasteurellaceae
Genus: Aggregatibacter
Species: Aggregatibacter actinomycetemcomitans
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Negative
Genome Size (bp) 2367908
No. of Coding Genes 2164
No. of Non-Coding Genes 74
No. of Small Non-Coding Genes 74
No. of Gene Transcripts 2249
No. of Pseudogenes 11
No. of Base Pairs 2367908
Description Aggregatibacter actinomycetemcomitans is a facultatively anaerobic, Gram negative, nonmotile bacterium that colonizes the human oral cavity. It is often found in association with localized aggressive periodontitis, a severe infection of the periodontium. It is also suspected to be involved in chronic periodontitis.
External Links Taxonomy ID
714
Genome Assembly ID
ASM159426v1
GOLD Organism ID
Go0486805
Disease Relevance
          Periodontal disease  [ICD-11: DA0C]
             Description Aggregatibacter actinomycetemcomitans was associated with chronic periodontitis. [1]
          Stroke  [ICD-11: 8B20]
             Description Stroke patients were more often carriers of Aggregatibacter actinomycetemcomitans in saliva. [2]
Host Genetic Factors (HGFs)
          AaHKsRNA107
             HGF ID HGF1087 HGF Info       Class Non-coding RNA: Small (ncRNA-sRNA)
             Description The expression of AaHKsRNA107 was 2.44-fold up-regulated during late-exponential phase of Aggregatibacter actinomycetemcomitans infection compared with early-exponential phase. [3]
          AaHKsRNA105
             HGF ID HGF1086 HGF Info       Class Non-coding RNA: Small (ncRNA-sRNA)
             Description The expression of AaHKsRNA105 was 2.64-fold up-regulated during late-exponential phase of Aggregatibacter actinomycetemcomitans infection compared with early-exponential phase. [3]
          AaHKsRNA082
             HGF ID HGF1085 HGF Info       Class Non-coding RNA: Small (ncRNA-sRNA)
             Description The expression of AaHKsRNA082 was 0.30-fold down-regulated during late-exponential phase of Aggregatibacter actinomycetemcomitans infection compared with early-exponential phase. [3]
          AaHKsRNA079
             HGF ID HGF1084 HGF Info       Class Non-coding RNA: Small (ncRNA-sRNA)
             Description The expression of AaHKsRNA079 was 0.36-fold down-regulated during late-exponential phase of Aggregatibacter actinomycetemcomitans infection compared with early-exponential phase. [3]
          AaHKsRNA064
             HGF ID HGF1083 HGF Info       Class Non-coding RNA: Small (ncRNA-sRNA)
             Description The expression of AaHKsRNA064 was 2.17-fold up-regulated during late-exponential phase of Aggregatibacter actinomycetemcomitans infection compared with early-exponential phase. [3]
          AaHKsRNA054
             HGF ID HGF1082 HGF Info       Class Non-coding RNA: Small (ncRNA-sRNA)
             Description The expression of AaHKsRNA054 was 5.11-fold up-regulated during late-exponential phase of Aggregatibacter actinomycetemcomitans infection compared with early-exponential phase. [3]
          AaHKsRNA050
             HGF ID HGF1081 HGF Info       Class Non-coding RNA: Small (ncRNA-sRNA)
             Description The expression of AaHKsRNA050 was 0.48-fold down-regulated during late-exponential phase of Aggregatibacter actinomycetemcomitans infection compared with early-exponential phase. [3]
          AaHKsRNA041
             HGF ID HGF1080 HGF Info       Class Non-coding RNA: Small (ncRNA-sRNA)
             Description The expression of AaHKsRNA041 was 2.04-fold up-regulated during late-exponential phase of Aggregatibacter actinomycetemcomitans infection compared with early-exponential phase. [3]
          AaHKsRNA038
             HGF ID HGF1079 HGF Info       Class Non-coding RNA: Small (ncRNA-sRNA)
             Description The expression of AaHKsRNA038 was 0.18-fold down-regulated during late-exponential phase of Aggregatibacter actinomycetemcomitans infection compared with early-exponential phase. [3]
          AaHKsRNA032
             HGF ID HGF1078 HGF Info       Class Non-coding RNA: Small (ncRNA-sRNA)
             Description The expression of AaHKsRNA032 was 2.75-fold up-regulated during late-exponential phase of Aggregatibacter actinomycetemcomitans infection compared with early-exponential phase. [3]
          AaHKsRNA017
             HGF ID HGF1077 HGF Info       Class Non-coding RNA: Small (ncRNA-sRNA)
             Description The expression of AaHKsRNA017 was 2.24-fold up-regulated during late-exponential phase of Aggregatibacter actinomycetemcomitans infection compared with early-exponential phase. [3]
          AaHKsRNA004
             HGF ID HGF1076 HGF Info       Class Non-coding RNA: Small (ncRNA-sRNA)
             Description The expression of AaHKsRNA004 was 2.51-fold up-regulated during late-exponential phase of Aggregatibacter actinomycetemcomitans infection compared with early-exponential phase. [3]
          AaHKsRNA003
             HGF ID HGF1075 HGF Info       Class Non-coding RNA: Small (ncRNA-sRNA)
             Description The expression of AaHKsRNA003 was 0.29-fold down-regulated during late-exponential phase of Aggregatibacter actinomycetemcomitans infection compared with early-exponential phase. [3]
          hsa-miR-891a-5p
             HGF ID HGF0700 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-891a was significantly induced down-regulation by Aggregatibacter actinomycetemcomitans (p-value<0.05). [4]
          hsa-let-7f-5p
             HGF ID HGF0297 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-let-7f targeted suppressors of cytokine signalling 4 (SOCS4) and thrombospondin-1 (TSP-1) during Aggregatibacter actinomycetemcomitans infection. [5]
          hsa-miR-146a-5p
             HGF ID HGF0252 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-146a was significantly induced down-regulation by Aggregatibacter actinomycetemcomitans (p-value<0.05). [4]
          hsa-miR-29b-3p
             HGF ID HGF0177 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-29b was significantly induced down-regulation by Aggregatibacter actinomycetemcomitans (p-value<0.05). [4]
          hsa-miR-32-5p
             HGF ID HGF0160 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-32 was significantly induced down-regulation by Aggregatibacter actinomycetemcomitans (p-value<0.05). [4]
          rs1057028
             HGF ID HGF1735 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The haplotype block rs1057028 was significantly associated with pathogens Aggregatibacter actinomycetemcomitans (p0.05). [6]
Host Immune Factors (HIFs)
          Dendritic cells
             HIF ID HIFC0003 HIF Info       Class Dendritic cells (DCs)
             Description Dendritic cells primed with different Aggregatibacter actinomycetemcomitans can stimulate naive CD 4+ T lymphocytes. [7]
          Neutrophils
             HIF ID HIFC0029 HIF Info       Class Granulocytes (Gra)
             Description Aggregatibacter actinomycetemcomitans induced Hypercitrullination in human neutrophils. [8]
          Immunoglobulin M
             HIF ID HIFM0266 HIF Info       Class Immunoglobulin (Ig)
             Description The activity of proteolytic enzymes from Actinobacillus actinomycetemcomitans could effect enzymolysis of human immunoglobulin M(lgM). [9]
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description IgG immune responses is associated with the Actinobacillus actinomycetemcomitans. [10]
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description The activity of proteolytic enzymes from Actinobacillus actinomycetemcomitans could effect enzymolysis of human immunoglobulin A(lgA). [9]
          M1 macrophages
             HIF ID HIFC0019 HIF Info       Class Macrophages (Mac)
             Description Aggregatibacter actinomycetemcomitans induced predominantly pro-inflammatory (M1 macrophages-like phenotypes) responses. [11]
          CD16 + monocytes
             HIF ID HIFC0118 HIF Info       Class Monocytes (Mono)
             Description CD16+ monocytes produced IL-6 in response to lipopolysaccharide from Actinobacillus actinomycetemcomitans. [12]
          CD16- monocytes
             HIF ID HIFC0119 HIF Info       Class Monocytes (Mono)
             Description CD16- monocytes produced IL-6 in response to lipopolysaccharide from Actinobacillus actinomycetemcomitans. [12]
          CD4+ T cells
             HIF ID HIFC0069 HIF Info       Class T cells (TCs)
             Description Dendritic cells primed with different Aggregatibacter actinomycetemcomitans can stimulate naive CD 4+ T lymphocytes. [7]
          T helper type 17 cells
             HIF ID HIFC0080 HIF Info       Class T cells (TCs)
             Description Aggregatibacter actinomycetemcomitans is associated with higher production of RANKL and these increased levels are associated with Th17 lymphocyte induction. [7]
Environmental Factor(s)
             Disbiome ID
      362
             aBiofilm Organism
      Aggregatibacter actinomycetemcomitans
References
1 Periopathogens in atherosclerotic plaques of patients with both cardiovascular disease and chronic periodontitis. ARYA Atheroscler. 2018 Mar;14(2):53-57. doi: 10.22122/arya.v14i2.1504.
2 Biomarkers of periodontitis and inflammation in ischemic stroke: A case-control study. Innate Immun. 2014 Jul;20(5):511-8. doi: 10.1177/1753425913501214. Epub 2013 Sep 17.
3 Small RNA repertoires and their intraspecies variation in Aggregatibacter actinomycetemcomitans. DNA Res. 2018 Apr 1;25(2):207-215. doi: 10.1093/dnares/dsx050.
4 MicroRNAs responsive to Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis LPS modulate expression of genes regulating innate immunity in human macrophages. Innate Immun. 2014 Jul;20(5):540-51. doi: 10.1177/1753425913501914. Epub 2013 Sep 23.
5 MicroRNAs and immunity in periodontal health and disease. Int J Oral Sci. 2018 Aug 6;10(3):24. doi: 10.1038/s41368-018-0025-y.
6 Common Polymorphisms in IFI16 and AIM2 Genes Are Associated With Periodontal Disease.J Periodontol. 2017 Jul;88(7):663-672. doi: 10.1902/jop.2017.160553. Epub 2017 Apr 7.
7 Serotype b of Aggregatibacter actinomycetemcomitans increases osteoclast and memory T-lymphocyte activation. Mol Oral Microbiol. 2016 Apr;31(2):162-74. doi: 10.1111/omi.12112. Epub 2015 Aug 10.
8 Talk to your gut: the oral-gut microbiome axis and its immunomodulatory role in the etiology of rheumatoid arthritis.FEMS Microbiol Rev. 2019 Jan 1;43(1):1-18. doi: 10.1093/femsre/fuy035.
9 Immunoglobulin-degrading enzymes in localized juvenile periodontitis.J Periodontal Res. 1992 May;27(3):176-83. doi: 10.1111/j.1600-0765.1992.tb01666.x.
10 Serum IgG antibody levels to periodontal microbiota are associated with incident Alzheimer disease.PLoS One. 2014 Dec 18;9(12):e114959. doi: 10.1371/journal.pone.0114959. eCollection 2014.
11 Oral Microbiota and Immune System Crosstalk: A Translational Research.Biology (Basel). 2020 Jun 16;9(6):131. doi: 10.3390/biology9060131.
12 Expression of CD14, CD16 and CD45RA on monocytes from periodontitis patients.J Periodontal Res. 2004 Feb;39(1):72-8. doi: 10.1111/j.1600-0765.2004.00713.x.

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