General Information of HIF (ID: HIFC0080)
HIF Name	T helper type 17 cells
HIF Synonym(s)	Th17, T helper type 17(Th17) cells
HIF Classification	T cells (TCs)
Description	T helper 17 cells ( Th17) are a subset of pro-inflammatory T helper cellsdefined by their production of interleukin 17 (IL-17). They are related to Tregulatory cells and the signals that cause T h 17s to differentiate actually inhibit Treg differentiation.				[1]

Microbe Species (MIC) Regulated by This HIF
Actinobacillus pleuropneumoniae (gamma-proteobacteria)			MIC00026
Description	Actinobacillus pleuropneumoniae-specific Th17 subsets induced the production of IL-17A and IL-10 cytokines.				[2]
Aggregatibacter actinomycetemcomitans (gamma-proteobacteria)			MIC00051
Description	Aggregatibacter actinomycetemcomitans is associated with higher production of RANKL and these increased levels are associated with Th17 lymphocyte induction.				[3]
Bacteroides fragilis (CFB bacteria)			MIC00158
Description	Polysaccharide A of Bacteroides fragilis resulted in interleukin 10 (IL-10) feedback by intestinal T cells, which restrained the accumulation of TH17 cells and potentially damaged the mucosal barrier.				[4]
Bifidobacterium bifidum (actinobacteria)			MIC00209
Description	Lactobacillus bifidus infection resulted in the increasement of T helper type 17 (Th17) cells in rheumatoid arthritis patients.				[5]
Blautia obeum (firmicutes)			MIC00240
Description	Blautia obeum is associated with T helper type 17 (Th17) cells responses.				[6]
Bordetella pertussis (beta-proteobacteria)			MIC00248
Description	Th17 response was promoted after parenteral immunization of mice with an experimental acellular pertussis vaccine formulated with LP-GMP, which conferred protection against lung infection with Bordetella pertussis.				[7]
Butyrivibrio fibrisolvens (firmicutes)			MIC00296
Description	Butyrivibrio is associated with T helper type 17 (Th17) cells responses.				[8]
Candida albicans (budding yeasts)			MIC00317
Description	Th17 cells can work with epithelial cells to clear the Candida albicans infection.				[9]
Candidatus Arthromitus (firmicutes)			MIC00319
Description	Th17 cell responses appear to be induced by a restricted number of microbial species Candidatus arthromitus.				[10]
Candidatus Arthromitus sp. SFB-mouse (firmicutes)			MIC01824
Description	Segmented filamentous bacteria (SFB) can induce a T helper type 17 (Th17) cells immune response.				[5]
Clostridium butyricum (firmicutes)			MIC00388
Description	Clostridium butyricum CGMCC0313.1 reduces pancreas inflammation and reversed the imbalance in Th1/Th2/Th17/Tregs.				[11]
Clostridium leptum (firmicutes)			MIC00402
Description	Early-life Clostridium leptum exposure induced an immunosuppressive environment in the lung, resulting in the inhibition of Th17 cell responses.				[12]
Clostridium perfringens (firmicutes)			MIC00411
Description	Most T helper type 17(Th17)cells hybridomas did not respond to Clostridium perfringens antigens.				[13]
Eggerthella lenta (actinobacteria)			MIC00520
Description	Eggerthella lenta induced the production of Th17 cytokines.				[14]
Enterococcus gallinarum (firmicutes)			MIC00550
Description	Monocolonization with Enterococcus gallinarum induced Th17 cells in the small intestinal lamina propria.				[15]
Helicobacter acinonychis (epsilon-proteobacteria)			MIC00662
Description	Helicobacter acinonychis is associated with T helper type 17 (Th17) cells responses.				[16]
Klebsiella pneumoniae (enterobacteria)			MIC01405
Description	Th17 cells can produce IL-17 in response to Klebsiella pneumoniae infection.				[17]
Lactococcus lactis (firmicutes)			MIC00745
Description	The Lactococcus lactis-delivered NapA(neutrophil-activating protein A subunit) can drive a polarized Th17 response.				[18]
Mycobacterium parascrofulaceum (actinobacteria)			MIC00853
Description	In Mycobacterium parascrofulaceum pulmonary infection, the exudative lesion had characteristics of Th2 and Th17-type immunities.				[19]
Mycoplasma pneumoniae (mycoplasmas)			MIC00875
Description	Thermobifida fusca was associated with Th17 immune response.				[20]
Porphyromonas gingivalis (CFB bacteria)			MIC01000
Description	Porphyromonas gingivalis promoted T helper type 17 (Th17) cells responses through the production of Th17-polarizing cytokines even in chronic periodontitis.				[5]
Prevotella copri (CFB bacteria)			MIC01010
Description	Prevotella copri induced production of IgA antibody responses which correlated with serum levels of a range of cytokines and chemokines associated with innate Th17 immune responses.				[21]
Prevotella nigrescens (CFB bacteria)			MIC01019
Description	Prevotella nigrescens appeared to favor the induction of TH17 cells in subjects affected by autoimmune experimental arthritis.				[22]
Pseudomonas aeruginosa (gamma-proteobacteria)			MIC01054
Description	A kill or inactivate but metabolically active Pseudomonas aeruginosa(deactivate enzymatic activity) could elicit Th17 pathways of cell-mediated immune responses.				[23]
Roseburia intestinalis (firmicutes)			MIC01118
Description	Roseburia intestinalis supernatant ameliorated inflammatory bowel disease colitis by reducing the number of Th17 cells in the colon.				[24]
Ruminococcus sp. (firmicutes)			MIC01140
Description	Ruminococcus is associated with T helper type 17(Th17)cells responses.				[25]
Salmonella enterica subsp. enterica (enterobacteria)			MIC01154
Description	Salmonella typhimurium could increase T helper type 17(Th17)cells responses.				[26]
Stenotrophomonas maltophilia (gamma-proteobacteria)			MIC01231
Description	Intranasal immunization with Stenotrophomonas maltophilia recombinant OmpA may trigger Th17-mediated cellular immune responses.				[27]
Tsukamurella paurometabola (actinobacteria)			MIC01338
Description	Tsukamurella paurometabola is associated with Th17 immune responses.				[28]

References
1	T helper type 17 cells in immune-mediated glomerular disease.Nat Rev Nephrol. 2017 Oct;13(10):647-659. doi: 10.1038/nrneph.2017.112. Epub 2017 Aug 7.
2	Actinobacillus pleuropneumoniae triggers IL-10 expression in tonsils to mediate colonisation and persistence of infection in pigs. Vet Immunol Immunopathol. 2018 Nov;205:17-23. doi: 10.1016/j.vetimm.2018.10.008. Epub 2018 Oct 22.
3	Serotype b of Aggregatibacter actinomycetemcomitans increases osteoclast and memory T-lymphocyte activation. Mol Oral Microbiol. 2016 Apr;31(2):162-74. doi: 10.1111/omi.12112. Epub 2015 Aug 10.
4	Impaired Autophagy in Intestinal Epithelial Cells Alters Gut Microbiota and Host Immune Responses.Appl Environ Microbiol. 2018 Aug 31;84(18):e00880-18. doi: 10.1128/AEM.00880-18. Print 2018 Sep 15.
5	Microbiota in T-cell homeostasis and inflammatory diseases.Exp Mol Med. 2017 May 26;49(5):e340. doi: 10.1038/emm.2017.36.
6	Circulating and Tissue-Resident CD4(+) T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation. Gastroenterology. 2017 Nov;153(5):1320-1337.e16. doi: 10.1053/j.gastro.2017.07.047. Epub 2017 Aug 4.
7	Sustained protective immunity against Bordetella pertussis nasal colonization by intranasal immunization with a vaccine-adjuvant combination that induces IL-17-secreting T(RM) cells. Mucosal Immunol. 2018 Nov;11(6):1763-1776. doi: 10.1038/s41385-018-0080-x. Epub 2018 Aug 20.
8	Relative abundance of Megamonas hypermegale and Butyrivibrio species decreased in the intestine and its possible association with the T cell aberration by metabolite alteration in patients with Behcet's disease (210 characters). Clin Rheumatol. 2019 May;38(5):1437-1445. doi: 10.1007/s10067-018-04419-8. Epub 2019 Jan 9.
9	Candida albicans-epithelial interactions and induction of mucosal innate immunity. Curr Opin Microbiol. 2017 Dec;40:104-112. doi: 10.1016/j.mib.2017.10.030. Epub 2017 Nov 17.
10	Gut microbiota, immunity, and disease: a complex relationship.Front Microbiol. 2011 Sep 5;2:180. doi: 10.3389/fmicb.2011.00180. eCollection 2011.
11	Clostridium butyricum CGMCC0313.1 Protects against Autoimmune Diabetes by Modulating Intestinal Immune Homeostasis and Inducing Pancreatic Regulatory T Cells. Front Immunol. 2017 Oct 19;8:1345. doi: 10.3389/fimmu.2017.01345. eCollection 2017.
12	Early-Life Exposure to Clostridium leptum Causes Pulmonary Immunosuppression. PLoS One. 2015 Nov 13;10(11):e0141717. doi: 10.1371/journal.pone.0141717. eCollection 2015.
13	Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation.Immunity. 2014 Apr 17;40(4):594-607. doi: 10.1016/j.immuni.2014.03.005. Epub 2014 Mar 27.
14	Autoimmunity-Associated Gut Commensals Modulate Gut Permeability and Immunity in Humanized Mice. Mil Med. 2019 Mar 1;184(Suppl 1):529-536. doi: 10.1093/milmed/usy309.
15	Translocation of a gut pathobiont drives autoimmunity in mice and humans. Science. 2018 Mar 9;359(6380):1156-1161. doi: 10.1126/science.aar7201.
16	Recombinant Bacillus subtilis Spores Elicit Th1/Th17-Polarized Immune Response in a Murine Model of Helicobacter pylori Vaccination. Mol Biotechnol. 2015 Aug;57(8):685-91. doi: 10.1007/s12033-015-9859-0.
17	Pseudomonas aeruginosa and Klebsiella pneumoniae Adaptation to Innate Immune Clearance Mechanisms in the Lung. J Innate Immun. 2018;10(5-6):442-454. doi: 10.1159/000487515. Epub 2018 Apr 4.
18	Production and delivery of Helicobacter pylori NapA in Lactococcus lactis and its protective efficacy and immune modulatory activity. Sci Rep. 2018 Apr 24;8(1):6435. doi: 10.1038/s41598-018-24879-x.
19	Immunopathological characteristics of immune reconstitution inflammatory syndrome caused by Mycobacterium parascrofulaceum infection in a patient with AIDS. Pathol Res Pract. 2011 Apr 15;207(4):262-70. doi: 10.1016/j.prp.2011.01.003. Epub 2011 Mar 4.
20	Data mining and systematic pharmacology to reveal the mechanisms of traditional Chinese medicine in Mycoplasma pneumoniae pneumonia treatment. Biomed Pharmacother. 2020 May;125:109900. doi: 10.1016/j.biopha.2020.109900. Epub 2020 Feb 3.
21	Evidence of the Immune Relevance of Prevotella copri, a Gut Microbe, in Patients With Rheumatoid Arthritis. Arthritis Rheumatol. 2017 May;69(5):964-975. doi: 10.1002/art.40003. Epub 2017 Apr 7.
22	Microbiota-Propelled T Helper 17 Cells in Inflammatory Diseases and Cancer. Microbiol Mol Biol Rev. 2020 Mar 4;84(2):e00064-19. doi: 10.1128/MMBR.00064-19. Print 2020 May 20.
23	Killed but metabolically active Pseudomonas aeruginosa-based vaccine induces protective humoral- and cell-mediated immunity against Pseudomonas aeruginosa pulmonary infections. Vaccine. 2018 Mar 27;36(14):1893-1900. doi: 10.1016/j.vaccine.2018.02.040. Epub 2018 Mar 2.
24	Roseburia intestinalis supernatant ameliorates colitis induced in mice by regulating the immune response. Mol Med Rep. 2019 Aug;20(2):1007-1016. doi: 10.3892/mmr.2019.10327. Epub 2019 Jun 4.
25	Microbial genes and pathways in inflammatory bowel disease. Nat Rev Microbiol. 2019 Aug;17(8):497-511. doi: 10.1038/s41579-019-0213-6.
26	Salmonella Typhimurium, the major causative agent of foodborne illness inactivated by a phage lysis system provides effective protection against lethal challenge by induction of robust cell-mediated immune responses and activation of dendritic cells. Vet Res. 2017 Oct 25;48(1):66. doi: 10.1186/s13567-017-0474-x.
27	Intranasal immunization with recombinant outer membrane protein A induces protective immune response against Stenotrophomonas maltophilia infection. PLoS One. 2019 Apr 1;14(4):e0214596. doi: 10.1371/journal.pone.0214596. eCollection 2019.
28	Deciphering the molecular basis of mycobacteria and lipoglycan recognition by the C-type lectin Dectin-2. Sci Rep. 2018 Nov 15;8(1):16840. doi: 10.1038/s41598-018-35393-5.

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