Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00240)
MIC Name Blautia obeum (firmicutes)
MIC Synonyms Ruminococcus obeum
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Blautia
Species: Blautia obeum
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Positive
Host Relationship Commensal
Genome Size (bp) 3625508
Description Blautia obeum is a species of anaerobic, Gram-positive bacteria found in the gut. It has been shown that B. obeum along with other relevant taxa play an important role both in the recovery process from V. cholerae infection and microbiota maturation in children.
External Links Taxonomy ID
40520
Genome Assembly ID
ASM15390v1
GOLD Organism ID
Go0000918
Disease Relevance
          Cerebral Infarction  [ICD-11: 8B11]
             Description Blautia obeum was associated with acute cerebral infarction. [1]
Host Genetic Factors (HGFs)
          NOD2
             HGF ID HGF2335 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of NOD2 showed significantly increased abundance of Blautia obeum (p-value<0.05). [2]
          rs5030728
             HGF ID HGF1280 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The variant gene TLR4 of innate immunity rs5030728 is significantly associated with the abundance of gut micriobiota Blautia obeum (p-value=0.0369). [3]
          rs17229285
             HGF ID HGF2578 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs17229285 SNP is associated with the abundance of Blautia obeum. [4]
          rs2836878
             HGF ID HGF2610 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs2836878 SNP is associated with the abundance of Blautia obeum. [4]
          rs10781499
             HGF ID HGF2620 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-SV)
             Description The rs10781499 SNP is associated with the abundance of Blautia obeum. [4]
          rs6667605
             HGF ID HGF2621 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs6667605 SNP is associated with the abundance of Blautia obeum. [4]
          rs9297145
             HGF ID HGF2622 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs9297145 SNP is associated with the abundance of Blautia obeum. [4]
          rs2111485
             HGF ID HGF2546 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs2111485 SNP is associated with the abundance of Blautia obeum. [4]
          rs7608910
             HGF ID HGF2613 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs7608910 SNP is associated with the abundance of Blautia obeum. [4]
          rs11879191
             HGF ID HGF2623 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs11879191 SNP is associated with the abundance of Blautia obeum. [4]
          rs6740462
             HGF ID HGF2537 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs6740462 SNP is associated with the abundance of Blautia obeum. [4]
          rs174537
             HGF ID HGF2611 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs174537 SNP is associated with the abundance of Blautia obeum. [4]
Host Immune Factors (HIFs)
          Cytotoxic T-lymphocyte-associated protein 4
             HIF ID HIFM0068 HIF Info       Class Checkpoint molecule (CM)
             Description Anti-CTLA-4 therapy in another melanoma cohort has been associated with baseline abundance in Ruminococcus obeum. [5]
          Programmed Cell Death 1 Protein
             HIF ID HIFM0191 HIF Info       Class Checkpoint molecule (CM)
             Description The lack of response to anti-PD-1 therapy has been associated with baseline abundance in Ruminococcus obeum. [5]
          CD4+ regulatory T cells
             HIF ID HIFC0034 HIF Info       Class T cells (TCs)
             Description Blautia obeum is associated with CD4+T cells responses. [6]
          CD4+ helper T cells
             HIF ID HIFC0068 HIF Info       Class T cells (TCs)
             Description Blautia obeum is associated with T-helper type 1 cells responses. [6]
          T helper type 17 cells
             HIF ID HIFC0080 HIF Info       Class T cells (TCs)
             Description Blautia obeum is associated with T helper type 17 (Th17) cells responses. [6]
Environmental Factor(s)
             Disbiome ID
      386
             gutMDisorder ID
      gm0117
References
1 Analysis of microbiota in elderly patients with Acute Cerebral Infarction. PeerJ. 2019 Jun 12;7:e6928. doi: 10.7717/peerj.6928. eCollection 2019.
2 Nod2 and Nod2-regulated microbiota protect BALB/c mice from diet-induced obesity and metabolic dysfunction.Sci Rep. 2017 Apr 3;7(1):548. doi: 10.1038/s41598-017-00484-2.
3 Variants in genes of innate immunity, appetite control and energy metabolism are associated with host cardiometabolic health and gut microbiota composition.Gut Microbes. 2020 May 3;11(3):556-568. doi: 10.1080/19490976.2019.1619440. Epub 2019 Jun 3.
4 A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice. Genetics. 2020 Mar;214(3):719-733. doi: 10.1534/genetics.119.303013. Epub 2020 Jan 2.
5 The gut microbiome and response to immune checkpoint inhibitors: preclinical and clinical strategies.Clin Transl Med. 2019 Mar 18;8(1):9. doi: 10.1186/s40169-019-0225-x.
6 Circulating and Tissue-Resident CD4(+) T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation. Gastroenterology. 2017 Nov;153(5):1320-1337.e16. doi: 10.1053/j.gastro.2017.07.047. Epub 2017 Aug 4.

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