General Information of HIF (ID: HIFM0191)
HIF Name	Programmed Cell Death 1 Protein
HIF Synonym(s)	CD279, PD-1, PDCD1
HIF Classification	Checkpoint molecule (CM)
Description	Programmed death-1 (PD-1, CD279) is one of the typical immune checkpoint molecules. By being expressed at appropriate timing and on appropriate cell types, it plays a major role in preventing overactivation of host immune system and in keeping immunological homeostasis and tolerance.				[1]
Pfam	Immunoglobulin V-set domain (PF07686 )
Pathway	Cell adhesion molecules (CAMs) (hsa04514 )
	PD-L1 expression and PD-1 checkpoint pathway in cancer (hsa05235 )
	T cell receptor signaling pathway (hsa04660 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	PDCD1_HUMAN

Microbe Species (MIC) Regulated by This HIF
Akkermansia muciniphila (verrucomicrobia)			MIC00056
Description	Akkermansia muciniphila may maintain the normal efficacy of PDCD1 antibody by affecting the metabolism of glycerophospholipid.				[2]
Alistipes indistinctus (CFB bacteria)			MIC00065
Description	Alistipes indistinctus could reverse resistance to PD-1 blockade.				[3]
Bacteroides caccae (CFB bacteria)			MIC00148
Description	The baseline enrichment in Bacteroides caccae has been associated with response to anti-PD-1 therapy in melanoma patients.				[3]
Bacteroides sp. (CFB bacteria)			MIC00176
Description	The relative abudance of the Bacteroide sp.is effected by PD-1 antibody treatment.				[2]
Bacteroides thetaiotaomicron (CFB bacteria)			MIC00179
Description	Bacteroides thetaiotaomicron have been negatively associated with response to anti-PD-1 therapy.				[3]
Blautia obeum (firmicutes)			MIC00240
Description	The lack of response to anti-PD-1 therapy has been associated with baseline abundance in Ruminococcus obeum.				[3]
Enterococcus hirae (firmicutes)			MIC00551
Description	Enterococcus hirae could reverse resistance to PD-1 blockade.				[3]
Faecalibacterium sp. (firmicutes)			MIC00589
Description	The abundance of Faecalibacterium genus was associated with increased CD8+ TILs and peripheral blood CD4+/CD8+ T-cells in human responders to PD-1 blockade.				[3]
Prevotella sp. (CFB bacteria)			MIC01024
Description	The relative abudance of the Prevotella sp.is effected by PD-1 antibody treatment.				[2]

References
1	Microbial biomarkers for immune checkpoint blockade therapy against cancer.J Gastroenterol. 2018 Sep;53(9):999-1005. doi: 10.1007/s00535-018-1492-9. Epub 2018 Jul 12.
2	Gut Microbiome Influences the Efficacy of PD-1 Antibody Immunotherapy on MSS-Type Colorectal Cancer via Metabolic Pathway.Front Microbiol. 2020 Apr 30;11:814. doi: 10.3389/fmicb.2020.00814. eCollection 2020.
3	The gut microbiome and response to immune checkpoint inhibitors: preclinical and clinical strategies.Clin Transl Med. 2019 Mar 18;8(1):9. doi: 10.1186/s40169-019-0225-x.

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